Design and Analysis

设计与分析

• 批准号: 9323531
• 负责人: Zhijin Jean Wu
• 金额: $ 31.24万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9323531
• 关键词: Archives; Area; Behavior; Behavioral; Behavioral Genetics; Brain; Brain imaging; Centers of Research Excellence; Characteristics; Cognitive Science; Collaborations; Communities; Complex; Computer Systems; Computer software; Data; Data Analyses; Data Storage and Retrieval; Development; Ensure; Faculty; Genetic; Genetic Markers; Genomics; High Performance Computing; Human Resources; Image; Imagery; Instruction; Lead; Libraries; Measures; Medical Genetics; Methodology; Methods; Mission; Modeling; Nature; Neuraxis; Neurosciences; Neurosciences Research; Phenotype; Physics; Process; Psychiatry; Research; Research Design; Research Infrastructure; Research Personnel; Research Project Grants; Resource Sharing; Resources; Secure; Series; Signal Transduction; Statistical Data Interpretation; Statistical Methods; Statistical Models; Training; Work; analytical method; clinical biomarkers; cluster computing; computer cluster; computing resources; cost effective; data archive; data management; design; experimental study; high dimensionality; high standard; mathematical model; meetings; method development; multidisciplinary; neuroimaging; neuroimaging marker; operation; predictive marker; programs; response; statistics; synergism; tool; working group

PROJECT SUMMARY (See instructions): Contemporary research in neuroimaging and neuroscience depends heavily on technical quantitative expertise in the areas of study design, statistical modeling and inference, and computation. The inclusion of a Design and Analysis Core is motivated by the need to provide access to COBRE investigators, and the neuroimaging research community at Brown, to the diverse set of tools and expertise required to conduct work in this area. Having a core with faculty and staff from the fields of statistics, neuroscience and physics will obviate or minimize the need for COBRE project leaders to seek these resources on their own. The primary mission of the DAC will be collaboration with COBRE investigators on issues related to design, analysis, and computing. We will work with investigators on standard aspects of design and analysis, and provide access to technical staff needed for acquiring and formatting image data, using computer clusters, implementing data analyses on various software platforms, and archiving project data (including image data) on servers. Several projects will demand development of new methodology, and the faculty configuration of the core is designed to respond to those demands and indeed to generate synergy in methods development. The core will coordinate and facilitate access to computational resources available to investigators. These resources include hardware (e.g., computing clusters, data archiving platforms), software (specialized programs such as AFNI, SPM, Brain Voyager; more general tools such as Matlab and R, and tools developed at Brown for visualization and analysis), and technical personnel with expertise in programming and software operation. The core will organize a regular working group and seminar series, providing a venue for the active exchange of ideas on design, statistical analysis and methodology, computation, software, and related issues between neuroimaging researchers both within and outside of Brown.

项目摘要（请参阅说明）：神经影像学和神经科学领域的当代研究在很大程度上取决于研究设计，统计建模和推理以及计算领域的技术定量专业知识。包括设计和分析核心的核心是为了提供对毛毛调查人员的访问权以及布朗的神经成像研究社区的启发，并向该领域开展工作所需的各种工具和专业知识。神经科学和物理学领域的核心与统计领域的教职员工将消除或最大程度地减少毛cre项目领导者自行寻求这些资源的需求。 DAC的主要任务是与COBRE调查人员就与设计，分析和计算有关的问题进行合作。我们将与调查人员在设计和分析的标准方面合作，并使用计算机簇，使用计算机簇，在各种软件平台上实施数据分析以及对服务器上的项目数据（包括图像数据）进行访问。几个项目将要求开发新方法，并且核心的教师配置旨在响应这些需求，并在方法开发中产生协同作用。 核心将协调并促进调查人员可用的计算资源。这些资源包括硬件（例如，计算簇，数据归档平台），软件（AFNI，SPM，Brain Voyager等专业程序； MATLAB和R等更通用的工具，以及在Brown上开发的工具，用于可视化和分析）以及具有编程和软件操作方面专业知识的技术人员。 核心将组织一个常规的工作组和研讨会系列，为设计，统计分析和方法论，计算，软件和相关问题的神经成像研究人员之间的研究人员提供积极交流的场所，使研究人员在布朗内外。