Translational Studies of Brain Circuitry Disrupted by Alcoholism

酒精中毒扰乱大脑回路的转化研究

基本信息

批准号：
9120720
负责人：
EDITH VIONI SULLIVAN
金额：
$ 21.67万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-10 至 2018-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9120720
关键词：
Adolescent Affect Age Aging Alcohol consumption Alcoholism Alcohols Amygdaloid structure Animal Model Animals Area Award Behavioral Behavioral Sciences Biological Markers Brain Brain Injuries Brain region Cerebrovascular Circulation Chronic Clinical Cognitive Collaborations Communities Complement Development Diffusion Magnetic Resonance Imaging Dose Drug usage Educational process of instructing Environment Equilibrium Exhibits Exposure to Faculty Fiber Financial compensation Functional Magnetic Resonance Imaging Funding Goals Health Heavy Drinking Human Image Impairment International Laboratories Location Magnetic Resonance Imaging Malnutrition Measures Mental Health Mentors Methods Modeling Motor NIH Program Announcements Names National Institute on Alcohol Abuse and Alcoholism Neuropsychological Tests Neurosciences Neurosciences Research Pattern Performance Physiologic pulse Process Productivity Psychiatry Psychology Public Health Radiology Specialty Rattus Recovery of Function Recruitment Activity Rehabilitation therapy Research Research Personnel Research Scientist Award Resources Rest Role Scanning Scientist Senior Scientist Award Sensory Severities Site Spin Labels Structure Students Support System System Targeted Research Testing Thinking Training Translating United States National Institutes of Health Universities Ventral Striatum Visual Visuospatial addiction alcohol exposure alcohol use disorder alcohol use initiation arm blood oxygen level dependent brain circuitry career development conflict resolution cytokine design gray matter in vivo innovation liver injury longitudinal design medical schools neural circuit neuroadaptation neuroimaging neuropathology neuropsychological next generation normal aging physical conditioning post-doctoral training problem drinker professor programs relating to nervous system response senescence sex skills therapy design translational study white matter

项目摘要

DESCRIPTION (provided by applicant): This K05 continuing application is in response to an NIAAA Program Announcement (PA-12-148) for a Senior Scientist Award and represents a synthesis of NIH-funded projects on which I am principal or named investigator. As a professor in the Department of Psychiatry and Behavioral Sciences at Stanford University School of Medicine, I am a scientist who conducts translational human and animal studies of the effects of alcoholism and aging on brain structure and function. The primary objective of this application is to extend my role as a scientist to that of a mentor who teaches and leads developing neuroscientists in all aspects of my neuroscience program. My program of research uses quantitative behavioral neuroscience approaches that are complemented with structural and functional magnetic resonance imaging (MRI and fMRI), diffusion tensor imaging (DTI), and pulse continuous arterial spin labeling (PCASL) with the aim of characterizing affected brain regions in alcoholism itself and in interaction with brain changes associated with development and senescence. My mentees will receive training in all aspects of my research with emphasis on behavioral experimental training for mentees with imaging backgrounds and training in imaging for mentees with psychology and behavioral backgrounds. I propose to have five mentees in each of the 5 years of the award, each for three to five years, all having completed postdoctoral training and now embarking on becoming independent investigators. Stanford University's neuroscience research community is dynamic, multifaceted, and interactive and attracts the brightest students, fellows, and faculty at all levels of career development. I have major collaborations in my own department as well as in Radiology, the Neuroscience Program, and SRI International. Fundamental to my research is access to advanced neuroimaging facilities and expertise for my own and my mentees' human and animal studies. The combined resources of my laboratory, across-site neuroimaging facilities, and the exceptional formal and informal neuroscience educational programs of the greater Stanford community provide a rich environment for my mentees. Common but often unrecognized untoward consequences of alcoholism are subtle but functionally significant impairments in cognitive, sensory, and motor functions. Identification of the brain systems supporting functions that remain relatively intact and those that are damaged in alcoholism with exacerbation from normal aging or subject to alcohol-related deviations from normal developmental trajectories is a crucial step in designing rehabilitation efforts for recruiting intact brain systems to compensate for damaged ones. Having the next generation of mentees engage in and then further their own research in these areas has notable potential relevance to public health concerns of addiction.

描述（由申请人提供）：此K05持续申请是针对高级科学家奖的NIAAA计划公告（PA-12-148），代表了我担任NIH资助的项目的综合，我是我担任该项目的负责人或指定的调查员。作为斯坦福大学医学院精神病学和行为科学系教授，我是一名科学家，他对酒精中毒和衰老对大脑结构和功能的影响进行翻译人类和动物研究。该应用程序的主要目的是将我作为科学家的角色扩展到一位在神经科学计划的各个方面教授和领导发展神经科学家的导师的角色。我的研究计划使用定量行为神经科学方法，这些方法与结构和功能性磁共振成像（MRI和FMRI），扩散张量成像（DTI）以及脉冲持续动脉自旋标记（PCASL）相辅相成，其目的是与酒精中毒本身以及与大脑相互作用相关的大脑区域以及与大脑变化相关的影响。我的受训者将在我的研究的各个方面接受培训，重点是针对具有成像背景的受训者的行为实验培训，并为具有心理学和行为背景的受训者进行成像培训。我建议在奖项的5年中的每一个中有五个受训者，每人三到五年，都完成了博士后培训，现在开始成为独立的调查员。斯坦福大学的神经科学研究社区充满活力，多方面和互动性，并吸引了各个职业发展的最聪明的学生，研究员和教师。我在自己的部门以及放射学，神经科学计划和SRI International中进行了主要合作。我的研究的基础是获得我自己和受训者的人类和动物研究的先进神经影像学设施和专业知识。我的实验室，跨站点神经影像学设施的综合资源以及大斯坦福社区的杰出正式和非正式的神经科学教育计划为我的受训者提供了丰富的环境。酒精中毒的常见但通常无法识别的不良后果是微妙的，但在认知，感觉和运动功能方面具有严重的障碍。鉴定支持保持相对完整的功能的大脑系统，以及在酒精中毒中受损的功能，从正常衰老或与酒精相关的正常发育轨迹造成的偏差加剧是在设计康复工作的关键步骤，以招募完整的脑部系统，以补偿受损的脑系统。让下一代的受训者参与其中，然后在这些领域进行自己的研究，这与成瘾的公共卫生问题显着相关。