SC COBRE for Developmentally Based Cardiovascular Diseases

SC COBRE 针对发育性心血管疾病

• 批准号: 8841754
• 负责人: ROGER R MARKWALD
• 金额: $ 109.77万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8841754
• 关键词: Achievement; Adult; Advisory Committees; Applications Grants; Award; Basic Science; Bioinformatics; Biomedical Engineering; Boston; Businesses; Cardiovascular Diseases; Cardiovascular system; Centers of Research Excellence; Childhood; Clinical; Clinical Research; Collaborations; Colon Carcinoma; Congenital Abnormality; Core Facility; Cost Sharing; Data; Degenerative Disorder; Dependence; Development; Developmental Biology; Disease; Economics; Education; Education and Outreach; Employment; Ensure; Equipment; Evaluation; Extramural Activities; Faculty; Fees; Fostering; Foundations; Funding; Funding Opportunities; Future; Genetic; Goals; Grant; Growth and Development function; Heart Valve Diseases; Historically Black Colleges and Universities; Home environment; Hospitals; Image; Institution; Interdisciplinary Study; Lead; Malignant Neoplasms; Marketing; Medicine; Mentors; Minority; Mission; Morbidity - disease rate; Morphology; Mouth Diseases; National Center for Research Resources; Operative Surgical Procedures; Oral health; Outcome; Pancreatitis; Paris, France; Patients; Peer Review; Phase; Pilot Projects; Positioning Attribute; Private Sector; Publications; Recovery; Regenerative Medicine; Research; Research Infrastructure; Research Personnel; Research Training; Resources; Scientist; Seeds; South Carolina; Stem cells; Stimulus; Strategic Planning; Structure; System; Technology; Testing; Tissue Engineering; Tissues; Training; Training Programs; Translating; Translational Research; United States National Institutes of Health; Universities; Work; arm; base; cardiogenesis; college; cost; experience; gene function; instrumentation; mortality; new technology; outreach; programs; prospective; ranpirnase; stem cell therapy; success; symposium; tissue regeneration; tool; voucher

This COBRE Phase III renewal is aimed at sustaining the research infrastructure built during the first ten years of NCRR funding. Our COBRE "Cardiovascular Developmental Biology Center" has become a nationally recognized, collaborative center with exclusive strengths in developmentally-related, cardiovascular diseases. Three underlying themes define the Center's research: understanding mechanisms of normal and abnormal heart and vascular development; investigating the developmental basis of adult cardiovascular diseases; and applying the principles of normal cardiovascular developmental biology to regenerative medicine or stem cell-based, tissue engineering. COBRE accomplishments towards these three "cradle to grave" goals include the recruitment of 8 new faculty, mentoring and training of 23 COBRE target faculty, and the development of 3 research core facilities. Programmatic outcomes include 28 independent research awards to target faculty, >410 peer reviewed publications, the State of South Carolina Center of Economic Excellence (COEE) awarding six endowed chairs in Regenerative Medicine and Advanced Tissue Biofabrication shared in partnerships with Clemson and the University of South Carolina, an NSF Research Infrastructure Improvement award to establish a statewide alliance in tissue fabrication, participation in the successful renewal of a statewide INBRE award in regenerative medicine, and funding of a translational award by the Leducq Foundation to create a Transatlantic Research Network exploring genetic mechanisms for valve diseases. For this PSO application, the plan for the Center transitioning to being independent of NIH/NCRR support during the next five years is to enhance and upgrade our core technologies, to increase their competitiveness to attract greater usage (and cost recovery), and to promote new research collaborations with our Center that can lead to submission of competitive research applications and broaden our statewide outreach, especially to other IDeA centers. A ten Step, five year strategic plan including implementing fee structures, pilot projects, outreach activities and programmatic development is proposed to sustain the CDBC/COBRE center and its three scientific cores (Morphology, Imaging and Instrumentation Core, Proteogenomics and Bioinformatics Core, and Gene Function Core). An Administrative Core, led by the founding director of MUSC's Cardiovascular COBRE, is home to the Program Coordinator and the Internal Advisory Committee. Together, they will act as the main operational arm of the Center. An External Advisory Committee will provide ongoing assessment and evaluation of the Center's progress. Institutional commitments from the Associate Provost for Research and Dean of the College of Medicine - exceeding one million dollars - help ensure programmatic growth development, and long-term sustainability of the Center.

COBRE 第三期更新旨在维持 NCRR 资助头十年期间建立的研究基础设施。我们的 COBRE“心血管发育生物学中心”已成为全国公认的合作中心，在发育相关的心血管疾病方面拥有独特的优势。该中心的研究定义了三个基本主题：了解正常和异常心脏和血管发育的机制；研究成人心血管疾病的发展基础；并将正常心血管发育生物学的原理应用于再生医学或基于干细胞的组织工程。 COBRE 在实现这三个“从摇篮到坟墓”目标方面取得的成就包括招聘 8 名新教师、指导和培训 23 名 COBRE 目标教师以及开发 3 个研究核心设施。计划成果包括向目标教师颁发 28 项独立研究奖、超过 410 份同行评审出版物、南卡罗来纳州经济卓越中心 (COEE) 与克莱姆森大学和南卡罗来纳大学合作授予再生医学和高级组织生物制造领域的 6 个特聘教授卡罗莱纳州，一项 NSF 研究基础设施改进奖，旨在建立全州组织制造联盟，参与全州再生医学 INBRE 奖的成功更新，并由 Leducq 资助转化奖基金会创建跨大西洋研究网络，探索瓣膜疾病的遗传机制。对于此 PSO 应用，该中心计划在未来五年内过渡到独立于 NIH/NCRR 支持，旨在增强和升级我们的核心技术，提高其竞争力以吸引更多使用（和成本回收），并促进与我们中心开展新的研究合作，可以提交有竞争力的研究申请，并扩大我们在全州范围内的覆盖范围，尤其是其他 IDeA 中心。提出了一项十步五年战略计划，包括实施费用结构、试点项目、外展活动和规划开发，以维持 CDBC/COBRE 中心及其三个科学核心（形态学、成像和仪器核心、蛋白质组学和生物信息学核心以及基因学）。功能核心）。由 MUSC 心血管 COBRE 创始主任领导的行政核心是项目协调员和内部咨询委员会的所在地。他们将共同充当该中心的主要运营部门。外部咨询委员会将对中心的进展进行持续评估和评估。负责研究的副教务长和医学院院长的机构承诺超过一百万美元，有助于确保中心的规划增长和长期可持续性。