SC COBRE for Developmentally Based Cardiovascular Diseases

SC COBRE 针对发育性心血管疾病

• 批准号: 8305805
• 负责人: ROGER R MARKWALD
• 金额: $ 109.77万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8305805
• 关键词: SC; COBRE; Developmentally; Based; Cardiovascular

This COBRE Phase III renewal is aimed at sustaining the research infrastructure built during the first ten years of NCRR funding. Our COBRE "Cardiovascular Developmental Biology Center" has become a nationally recognized, collaborative center with exclusive strengths in developmentally-related, cardiovascular diseases. Three underlying themes define the Center's research: understanding mechanisms of normal and abnormal heart and vascular development; investigating the developmental basis of adult cardiovascular diseases; and applying the principles of normal cardiovascular developmental biology to regenerative medicine or stem cell-based, tissue engineering. COBRE accomplishments towards these three "cradle to grave" goals include the recruitment of 8 new faculty, mentoring and training of 23 COBRE target faculty, and the development of 3 research core facilities. Programmatic outcomes include 28 independent research awards to target faculty, >410 peer reviewed publications, the State of South Carolina Center of Economic Excellence (COEE) awarding six endowed chairs in Regenerative Medicine and Advanced Tissue Biofabrication shared in partnerships with Clemson and the University of South Carolina, an NSF Research Infrastructure Improvement award to establish a statewide alliance in tissue fabrication, participation in the successful renewal of a statewide INBRE award in regenerative medicine, and funding of a translational award by the Leducq Foundation to create a Transatlantic Research Network exploring genetic mechanisms for valve diseases. For this PSO application, the plan for the Center transitioning to being independent of NIH/NCRR support during the next five years is to enhance and upgrade our core technologies, to increase their competitiveness to attract greater usage (and cost recovery), and to promote new research collaborations with our Center that can lead to submission of competitive research applications and broaden our statewide outreach, especially to other IDeA centers. A ten Step, five year strategic plan including implementing fee structures, pilot projects, outreach activities and programmatic development is proposed to sustain the CDBC/COBRE center and its three scientific cores (Morphology, Imaging and Instrumentation Core, Proteogenomics and Bioinformatics Core, and Gene Function Core). An Administrative Core, led by the founding director of MUSC's Cardiovascular COBRE, is home to the Program Coordinator and the Internal Advisory Committee. Together, they will act as the main operational arm of the Center. An External Advisory Committee will provide ongoing assessment and evaluation of the Center's progress. Institutional commitments from the Associate Provost for Research and Dean of the College of Medicine - exceeding one million dollars - help ensure programmatic growth development, and long-term sustainability of the Center.

这一牢固的III阶段更新旨在维持NCRR资助的前十年中建立的研究基础设施。我们的山脉“心血管发育生物学中心”已成为一个全国认可的协作中心，具有与发育相关的心血管疾病的独特优势。三个基本主题定义了该中心的研究：了解正常和异常心脏和血管发育的机制；研究成人心血管疾病的发育基础；并将正常心血管发育生物学原理应用于再生医学或基于干细胞的组织工程。实现这三个“摇篮到严重”目标的鞋垫成就包括招募8位新教师，23个毛茸茸的目标教师的指导和培训以及3个研究核心设施的发展。 Programmatic outcomes include 28 independent research awards to target faculty, >410 peer reviewed publications, the State of South Carolina Center of Economic Excellence (COEE) awarding six endowed chairs in Regenerative Medicine and Advanced Tissue Biofabrication shared in partnerships with Clemson and the University of South Carolina, an NSF Research Infrastructure Improvement award to establish a statewide alliance in tissue fabrication, participation in the successful续签全州近乎再生医学的近亲奖，以及Leducq基金会的翻译奖，以建立跨大西洋研究网络探索瓣膜疾病的遗传机制。对于此PSO应用，在接下来的五年中，该中心过渡到独立于NIH/NCRR支持的计划是增强和升级我们的核心技术，以提高其竞争力，以吸引更大的用法（和成本恢复），并与我们的中心一起促进新的研究合作，并可以导致有竞争力的研究应用程序，并导致我们的State stauge confiment of Comperiation Inspean uswide uten uneach uterach，尤其是其他Insure Chemers，尤其是其他Insure Centor。提出了十个步骤，五年的战略计划，包括实施费用结构，试点项目，外展活动和程序性开发，以维持CDBC/COBRE中心及其三个科学核心（形态，成像和仪器核心，蛋白质组学和生物信息学核心和基因功能）。由MUSC心血管鞋底的创始董事领导的行政核心是该计划协调员和内部咨询委员会的所在地。他们将共同充当中心的主要运营部门。外部咨询委员会将对中心的进度进行持续的评估和评估。医学院研究和院长的副教务长的机构承诺（超过100万美元）有助于确保程序化增长的发展和中心的长期可持续性。