PROTEIN SCIENCE TRANSLATION CORE

蛋白质科学翻译核心

基本信息

批准号：
8883582
负责人：
YI-TE HSU
金额：
$ 14.75万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至 2016-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8883582
关键词：
Achievement Antibodies Awareness Biological Assay Cardiovascular Diseases Cell Line Centers of Research Excellence Chemicals Circular Dichroism Clinical Sciences Consultations Diabetes Mellitus Disease Education Enzymes Escherichia coli Extramural Activities Faculty Fatty acid glycerol esters Fees Funding Grant High Pressure Liquid Chromatography Immunoprecipitation In Vitro Individual Industry Institutes Label Lipid Binding Lipids Malignant Neoplasms Mammalian Cell Mentors Metabolic Modification NMR Spectroscopy Nerve Degeneration Phase Postdoctoral Fellow Preclinical Drug Evaluation Production Proteins Proteomics Recombinant Proteins Recombinants Regulation Research Research Institute Research Personnel Resources Role Science Services Signal Transduction South Carolina Structure Students Suggestion Surface Plasmon Resonance System Therapeutic Translational Research Translations Validation Western Blotting Work X-Ray Crystallography base design drug development drug discovery fast protein liquid chromatography high throughput screening improved inhibitor/antagonist innovation instrumentation interest light scattering lipid metabolism medical specialties member novel physical state pre-clinical programs protein expression protein protein interaction protein purification protein structure function screening structural biology success

项目摘要

The Protein Science Translation Core was created to assist Investigators of the COBRE in Lipidomics and Pathobiology in studying structures and functions of proteins involved in the regulation of lipid metabolism and signaling. Over the years, the Core has transitioned from a strictly consultative role to a more active role in servicing investigators in various aspects of protein science. Moreover, as the bulk of research in the COBRE continues to evolve towards pre-clinical and translational sciences, the Core has become essential in supporting this effort by enabling studies on target validation and enzyme-targeted translational research and therapeutics. Since 2002, the Core has serviced more than 25 investigators and worked on 35 proteins. The aims of the Core during Phase III of COBRE funding are to: 1) produce proteins of interest for individual investigators that are needed for structural and functional characterization and for translational research programs at MUSC; 2) offer a wide range of protein-related specialty services to suit the needs of investigators and to coordinate the needs of Center investigators with other existing facilities at MUSC; and 3) enhance the understanding and capability of investigators in protein science through mentoring, consultation, and promotional seminars. Taken together, these aims will contribute to the scientific achievement of investigators in South Carolina whose research involve some aspects of protein science, which in the long run could contribute to the development of drugs against specific diseases. The usefulness and popularity of the Core will in turn enhance its prospect in achieving self-sustainability.

蛋白质科学翻译核心的创建是为了协助 COBRE 脂质组学和病理生物学研究人员研究参与脂质代谢和信号传导调节的蛋白质的结构和功能。多年来，核心已经从严格的咨询角色转变为更积极地为蛋白质科学各个方面的研究人员提供服务。此外，随着 COBRE 的大部分研究继续向临床前和转化科学发展，核心通过实现目标验证和酶靶向转化研究和治疗学的研究，成为支持这一努力的关键。自 2002 年以来，Core 已为超过 25 名研究人员提供服务，研究了 35 种蛋白质。 COBRE 资助的第三阶段核心的目标是：1）为个体研究人员生产结构和功能表征以及 MUSC 转化研究项目所需的感兴趣的蛋白质； 2) 提供广泛的蛋白质相关专业服务，以满足研究人员的需求，并协调中心研究人员与 MUSC 的其他现有设施的需求； 3) 通过指导、咨询和推广研讨会提高研究者对蛋白质科学的理解和能力。总而言之，这些目标将有助于南卡罗来纳州研究人员取得科学成就，他们的研究涉及蛋白质科学的某些方面，从长远来看，这可能有助于开发针对特定疾病的药物。核心的有用性和受欢迎程度反过来将增强其实现自我可持续发展的前景。