BCL-2 AND BAX REGULATION OF APOPTOSIS IN CARDIOVASCULAR PATHOLOGY

BCL-2 和 BAX 对心血管病理中细胞凋亡的调节

• 批准号: 7170461
• 负责人: YI-TE HSU
• 金额: $ 6.93万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7170461
• 关键词: cardiovascular disorder; clinical research; genetics; health science research; pathologic process

DESCRIPTION (provided by applicant): We will establish a center to promote the study of cardiovascular diseases in South Carolina. Our COBRE focus on cardiovascular disease is significant because the citizens of our state are more prone to cardiovascular disease than anywhere else in the nation. For this reason, the two medical schools in the state have united to develop the South Carolina COBRE on Cardiovascular Disease. This COME will significantly augment joint efforts in South Carolina to recruit, train and retain a critical mass of investigators with multidisciplinary skills and adequate infrastructure to: (1) collaborate effectively in fundamental mechanistic studies of cardiovascular diseases, and (2) compete successfully at the national level for NIH and other merit-reviewed funding required to support and extend their research endeavors. Five scientific projects proposed by talented, newly recruited tenure-track faculty from five different departments, three high tech scientific cores (transgenics, imaging, microarray/proteomics) directed by outstanding investigators with proven track records in their area of expertise and an administrative/mentoring core comprise the proposed center. The overarching theme is that cardiovascular diseases derive from final common pathogenic pathways: proliferation, remodeling, apoptosis, transdifferentiation and vasculogenesis, each of which is the focus of one or more projects. While the thematic focus is cardiovascular, the operant theme for implementation is mentoring. In states that are less competitive for research funding at the national level, effective mentoring of new investigators is an essential element of a research development plan. This proposal addresses this need directly by: (1) pairing targeted investigators with established NIH-funded researchers who have exceptional mentoring track records as well as relevant critical expertise; (2) developing structured activities for skills acquisition and enhancement, such as seminars, journal clubs, retreats and special courses; (3) guaranteeing access to essential core resources with sufficient scientific expertise and technical support to optimize their use; and (4) implementing a regular schedule (checkpoints) of progress reports and evaluation with critical assistance from an External Advisory Committee of nationally recognized scientists.

描述（由申请人提供）：我们将建立一个促进的中心 南卡罗来纳州心血管疾病的研究。我们的毛病专注于 心血管疾病很重要，因为我们州的公民是 比全国其他任何地方都更容易患心血管疾病。为了 这个原因，该州的两所医学院团结起来开发 南卡罗来纳州心血管疾病的毛绒。这个来了 扩大南卡罗来纳州的联合努力以招募，培训和保留 具有多学科技能和足够技能的研究人员的批判质量 基础架构：（1）有效地在基本机理中进行合作 心血管疾病的研究，以及（2）在 支持NIH的国家级别和其他绩效评估的资金 并扩大他们的研究努力。提出的五个科学项目 来自五种不同的才华横溢，新招募的终身教师 部门，三个高科技科学核心（转基因，成像， 微阵列/蛋白质组学）由杰出的调查员执导，具有经过验证的轨道 其专业领域的记录和行政/指导核心 组成拟议中心。总体主题是心血管 源自最终常见致病途径的疾病：增殖， 重塑，细胞凋亡，转分化和血管生成，每种 是一个或多个项目的重点。主题重点是 心血管，实施的操作主题是指导。在州 在国家一级的研究资金竞争力较低， 有效指导新调查人员是研究的重要因素 发展计划。该建议直接解决了这一需求：（1）配对 有针对性的研究人员，已有NIH资助的研究人员 出色的指导记录以及相关的关键专业知识； （2）开发技能获取和增强的结构化活动， 例如研讨会，期刊俱乐部，务虚会和特殊课程； （3） 通过足够科学的科学保证获得基本核心资源 专业知识和技术支持以优化其使用； （4）实施 进行进度报告和评估的常规时间表（检查点） 全国外部咨询委员会的重要援助 公认的科学家。