Children's Research Institute Hematology Research Training Grant

儿童研究所血液学研究培训补助金

• 批准号: 9025570
• 负责人: NAOMI L LUBAN
• 金额: --
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-02-01 至 2017-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9025570
• 关键词: Child; Grant; Hematology; Research Institute; Research Training

PROJECT SUMMARY The conduct of high quality and transformative research in pediatric transfusion medicine and hematology is complicated by several barriers including, 1) lack of a robust infrastructure for research training and implementation; 2) shortage of mid-career and senior investigators to serve as research mentors; 3) need for multidisciplinary translational approaches to answer critical clinical questions; 4) lack of diversity among clinical and translational investigators with respect to minority status and gender despite a disproportionate number of under-represented infants and children minority with diseases and disorders which could benefit from such investigations. We use this application to propose a highly collaborative and multidisciplinary, inter-institutional program of mentored training for future scientists in pediatric transfusion medicine and hematology that will address these barriers. It will focus on advancing clinical and translational scholarship on the diagnosis and clinical management of hematological, cardiovascular and pulmonary disorders, transfusion and transplantation. The program, the Pediatric Hematology and Transfusion Medicine Multidisciplinary Research Training Award (PHTMMRT) will have the long-term objective of preparing trainees from diverse backgrounds for academic leadership and independently funded research careers. Each trainee in the program will complete a Master's Degree in Clinical and Translational Science (MsCTR) at the George Washington University School of Medicine and Health Sciences (GWU) and will devise, implement and complete a research project under the joint oversight of multidisciplinary mentorship team. At the completion of the three year program, each trainee will have presented his/her data at least at one national research meeting, drafted and submitted one or more manuscripts suitable for external peer-reviewed publications, and submitted an external grant application to the NIH or equivalent funding source. The program will be overseen by two highly qualified and NIH-funded Principal Investigators/Program Directors (PIs/PDs) with distinct and complementary clinical backgrounds and research expertise. They will be supported by 9 faculty of Children's National and its affiliated GWU School of Medicine and Health Sciences (GWU) with 9 external mentors who are research scientists with expertise in coagulation, transfusion medicine, transplantation, sickle cell disease and vascular biology. A Diversity Enhancement Officer, a full professor and funded investigator, will assist in the recruitment of minority, disabled or disadvantaged applicants, and women. Finally, an External Advisory Committee, composed of 6 NIH-funded national leaders in transfusion medicine and hematology with established career mentorship programs, will offer annual feedback and guidance with respect to development of the PHTMMRT program and to the trainees' progress. The PHTMMRT program will directly address each of the barriers noted above by leveraging several of Children's National's (CNMC) multiple and pre-existing strengths with collaborating neighboring research institutions including the NIH, American Red Cross, FDA and Howard University School of Medicine which provide outstanding training opportunities. These strengths include 1.a) the availability of translational and clinical scientists across the full spectrum from mechanistic investigations to health services research; 1.b) a pool of experienced NIH funded faculty who with our external mentors provide access to unparalleled core facilities and research training; 2) our large, local community of K Scholars and other trainees which, through a Council of Trainees, will provide collegial, formal and informal, interdisciplinary learning opportunities in team science; 3) our robust CTSA-funded infrastructure for supporting trainee research, including a MS in Clinical and Translational Research; 4) our longstanding commitment to recruit and train investigators from diverse clinical disciplines who are under-represented minorities or women. Our multidisciplinary, inter-institutional mentors will train four future academic leaders in Pediatric Hematology and Transfusion Medicine, who will lead both clinical and translational research teams, compete successfully for grant support and provide novel insights into the causes, pathophysiology and treatment of pediatric diseases that affect the Nation's children.

项目摘要 小儿输血医学和血液学的高质量和变革性研究的进行是 由于几个障碍，包括，1）缺乏用于研究培训的强大基础设施和 执行; 2）职业中期和高级调查员短缺作为研究导师； 3）需要 多学科翻译方法回答关键的临床问题； 4）临床缺乏多样性 尽管数量不成比例 代表性不足的婴儿和少数患有疾病和疾病的儿童可能会受益于这种疾病和疾病 调查。 我们使用此应用程序提出了一个高度协作和多学科的，机构间计划的 为未来的科学家在小儿输血医学和血液学方面的指导培训，这些培训将解决这些问题 障碍。它将重点介绍有关诊断和临床的临床和转化奖学金 血液学，心血管和肺部疾病，输血和移植的管理。这 计划，小儿血液学和输血医学多学科研究培训 奖项（PHTMMRT）将具有为来自不同背景的学员准备的长期目标 学术领导和独立资助的研究职业。该计划中的每个学员将完成 乔治华盛顿大学临床和转化科学硕士学位（MSCTR） 医学与健康科学（GWU）将设计，实施和完成一个研究项目 对多学科指导团队的共同监督。三年计划完成时，每个受训者 至少在一次国家研究会议上介绍了他/她的数据，起草并提交了一个或多个 适合外部同行评审出版物的手稿，并向 NIH或同等资金来源。该计划将由两个高素质和NIH资助的人监督 主要研究人员/计划主管（PIS/PDS）具有独特和互补的临床背景和 研究专业知识。他们将得到9位儿童国家教职员工及其附属的GWU学校的支持 医学与健康科学（GWU），有9位外部导师，他们是具有专业知识的研究科学家 凝血，输血，移植，镰状细胞疾病和血管生物学。多样性 完整的教授和资助的调查员增强官将协助招募少数民族， 残疾或处境不利的申请人和妇女。最后，由6个组成的外部咨询委员会 由NIH资助的全国排血医学和血液学领导者和既定职业指导 计划，将提供有关PHTMMRT计划的开发的年度反馈和指导 到学员的进步。 PHTMMRT程序将通过利用几个 儿童国民（CNMC）多重和现有的优势与邻近的研究 包括NIH，美国红十字会，FDA和霍华德大学医学院在内的机构 提供出色的培训机会。这些优势包括1.a）翻译的可用性 从机械调查到卫生服务研究的整个范围内的临床科学家； 1.b）a 经验丰富的NIH资助教师，他们与我们的外部导师一起提供无与伦比的核心 设施和研究培训； 2）我们庞大的当地K学者和其他学员社区，通过A 受训者理事会将在团队中提供联盟，正式和非正式的跨学科学习机会 科学; 3）我们的强大CTSA资助的基础设施用于支持学员研究，包括临床中的MS 和翻译研究； 4）我们长期致力于招募和培训各种各样的调查员 代表性不足的少数群体或妇女的临床学科。 我们的多学科，机构间导师将培训四名未来儿科血液学的学术领导者 将领导临床和转化研究团队的输血医学，成功竞争 提供赠款支持，并提供有关小儿原因，病理生理学和治疗的新见解 影响国家子女的疾病。