Clinical and Translational Science Institute at Childrens National-Mentored Career Development Core

儿童国家指导职业发展核心的临床和转化科学研究所

基本信息

批准号：
9308042
负责人：
NAOMI L LUBAN
金额：
$ 36.4万
依托单位：
CHILDREN'S RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-07-01 至 2021-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9308042
关键词：
Acceleration Adult Affinity Applications Grants Area Bioinformatics Biological Biomedical Engineering Chemicals Child Child health care Childhood Clinic Clinical Research Clinical Sciences Clinical Trials Competence Data Development Plans Disease Distance Education E-learning Education Educational Curriculum Ensure Epidemiology Evaluation Funding Genomics Grant Health Policy Health Services Health Services Research Health system Industry Institutes Institution Laboratories Lead Leadership Learning Measures Medical Mentors Mentorship Methodology Methods Recruitment Activity Research Resources Science South Carolina Structure Systems Biology Time Training Training Programs Translating Translational Research United States National Institutes of Health Universities Virginia Washington bioimaging career career development clinical application clinical phenotype clinical translation design education research externship health disparity innovation meetings multidisciplinary novel programs skill acquisition skills symposium

项目摘要

Contact PD/PI: Guay-Woodford, Lisa Marie Inst-Career-Dev-001 (495) Project Summary Abstract We propose a Mentored Career Development Plan that will utilize the resources of CTSI-CN v2.0 and our partner institutions, Children's National Health System, the George Washington University and Virginia Tech/Carilion Clinic. The focus of the KL2 program is on childhood disorders as precursors of adult disease. We propose an approach with team mentorship, multi-institutional courses and access to a large research skills development toolbox. It will also provide a strong portfolio of biomedical, health services, pharma, industry, and not-for-profit externships. Our research education paradigm utilizes blended learning that includes distance education and an online learning portal. Through the resources of the CTSA Scholarly Oversight Committee and the Grants Enhancement Program, the KL2 scholar will master CTR core competencies and be well prepared in all aspects of developing and submitting competitive NIH grant applications by the end of their training period. Of high priority is promoting diversity among recruited scholars and mentors, with specific strategies proposed for recruitment, retention and individualized supports. The KL2 scholar will: 1) complete graduate level courses in CTR, bioinformatics, systems biology, and health policy relevant to their area of research; 2) learn state-of-the-art laboratory, statistical, and epidemiological methodologies; 3) collect and analyze preliminary data with guidance from a Lead Mentor and Mentorship Team; 4) prepare and submit an NIH grant application; and 5) become versed in various strategies to translate their scientific findings into the next stages of clinical applications. Our proposed program ensures scholars will have 75% protected time. We draw on 48 mentors/co-mentors in affinity areas that include genomics/proteinomic with clinical phenotyping; chemical/biological/cellular therapies; biomedical imaging and engineering; rigorous clinical trials; and health disparities/health services research. Our scholars will participate in CTSA-network activities including a distance externship program initiated by the Medical University of South Carolina CTSA; our novel R25 curriculum entitled “Innovations in Pediatric CTR Education”; a planned R13- supported satellite conference for pediatric-focused KL2s at the annual Association for Clinical and Translation Science meeting, and a multidisciplinary consortium pilot program proposed in the CTSI-CN U54-application, the “Child Health Research Acceleration through Multisite Planning (CHAMP)”. The administrative structure of the KL2 includes a Project Lead and three Project Co-Leads with complementary skill sets in clinical research, team science/leadership, and educational design. We propose to select and train 9 scholars over the grant period, 4 with federal and 5 with institutional funding. We will use ongoing evaluation methods to continuously strengthen and refine out training program and measure its long-term impact on scientific careers and research contributions in CTR.

联系 PD/PI：Guay-Woodford、Lisa Marie Inst-Career-Dev-001 (495) 项目概要摘要我们提出了一个指导性职业发展计划，该计划将利用 CTSI-CN v2.0 的资源和我们的合作机构：儿童国家卫生系统、乔治华盛顿大学和弗吉尼亚州 Tech/Carilion 诊所。KL2 项目的重点是作为成人疾病先兆的儿童疾病。我们提出了一种包含团队指导、多机构课程和大型研究的方法它还将提供强大的生物医学、健康服务、制药、我们的研究教育范式利用混合学习。包括远程教育和在线学习门户通过 CTSA 学术资源。监督委员会和补助金增强计划，KL2学者将掌握CTR核心能力，并在制定和提交竞争性 NIH 拨款的各个方面做好充分准备当务之急是促进招募学者的多样性。和导师，并提出了招聘、保留和个性化支持的具体策略。学者将： 1) 完成 CTR、生物信息学、系统生物学和卫生政策方面的研究生课程 2）学习最先进的实验室、统计和流行病学 3）在首席导师和导师的指导下收集和分析初步数据团队；4) 准备并提交 NIH 拨款申请；5) 精通各种翻译策略；我们提出的计划确保学者们能够将他们的科学发现转化为临床应用的下一阶段。我们有 75% 的受保护时间，其中包括 48 名亲和领域的导师/共同导师。基因组学/蛋白质组学与临床表型分析；化学/生物/细胞疗法；工程；严格的临床试验；以及健康差异/健康服务研究。参与 CTSA 网络活动，包括南方医科大学发起的远程实习计划卡罗莱纳州 CTSA；我们的新颖 R25 课程，题为“儿科 CTR 教育的创新”，计划中的 R13- 在年度临床和翻译协会上支持以儿科为重点的 KL2 卫星会议科学会议以及 CTSI-CN U54 应用程序中提出的多学科联盟试点计划， “通过多站点规划加速儿童健康研究（CHAMP）”的管理结构。 KL2 包括一名项目负责人和三名项目联合负责人，他们在临床研究方面具有互补的技能，我们建议通过赠款选择和培训 9 名学者。期间，4 个由联邦资助，5 个由机构资助，我们将使用持续评估方法来持续进行。加强和完善培训计划并衡量其对科学职业和研究的长期影响对点击率的贡献。