Children's Research Institute Hematology Research Training Grant

儿童研究所血液学研究培训补助金

• 批准号: 8213944
• 负责人: NAOMI L LUBAN
• 金额: $ 7.3万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-02-01 至 2017-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8213944
• 关键词: Child; Grant; Hematology; Research Institute; Research Training

DESCRIPTION (provided by applicant): The conduct of high quality and transformative research in pediatric transfusion medicine and hematology is complicated by several barriers including, 1) lack of a robust infrastructure for research training and implementation; 2) shortage of mid-career and senior investigators to serve as research mentors; 3) need for multidisciplinary translational approaches to answer critical clinical questions; 4) lack of diversity among clinical and translational investigators with respect to minority status and gender despite a disproportionate number of under-represented infants and children minority with diseases and disorders which could benefit from such investigations. We use this application to propose a highly collaborative and multidisciplinary, inter-institutional program of mentored training for future scientists in pediatric transfusion medicine and hematology that will address these barriers. It will focus on advancing clinical and translational scholarship on the diagnosis and clinical management of hematological, cardiovascular and pulmonary disorders, transfusion and transplantation. The program, the Pediatric Hematology and Transfusion Medicine Multidisciplinary Research Training Award (PHTMMRT) will have the long-term objective of preparing trainees from diverse backgrounds for academic leadership and independently funded research careers. Each trainee in the program will complete a Master's Degree in Clinical and Translational Science (MsCTR) at the George Washington University School of Medicine and Health Sciences (GWU) and will devise, implement and complete a research project under the joint oversight of multidisciplinary mentorship team. At the completion of the three year program, each trainee will have presented his/her data at least at one national research meeting, drafted and submitted one or more manuscripts suitable for external peer-reviewed publications, and submitted an external grant application to the NIH or equivalent funding source. The program will be overseen by two highly qualified and NIH-funded Principal Investigators/Program Directors (PIs/PDs) with distinct and complementary clinical backgrounds and research expertise. They will be supported by 9 faculty of Children's National and its affiliated GWU School of Medicine and Health Sciences (GWU) with 9 external mentors who are research scientists with expertise in coagulation, transfusion medicine, transplantation, sickle cell disease and vascular biology. A Diversity Enhancement Officer, a full professor and funded investigator, will assist in the recruitment of minority, disabled or disadvantaged applicants, and women. Finally, an External Advisory Committee, composed of 6 NIH-funded national leaders in transfusion medicine and hematology with established career mentorship programs, will offer annual feedback and guidance with respect to development of the PHTMMRT program and to the trainees' progress. The PHTMMRT program will directly address each of the barriers noted above by leveraging several of Children's National's (CNMC) multiple and pre-existing strengths with collaborating neighboring research institutions including the NIH, American Red Cross, FDA and Howard University School of Medicine which provide outstanding training opportunities. These strengths include 1.a) the availability of translational and clinical scientists across the full spectrum from mechanistic investigations to health services research; 1.b) a pool of experienced NIH funded faculty who with our external mentors provide access to unparalleled core facilities and research training; 2) our large, local community of K Scholars and other trainees which, through a Council of Trainees, will provide collegial, formal and informal, interdisciplinary learning opportunities in team science; 3) our robust CTSA-funded infrastructure for supporting trainee research, including a MS in Clinical and Translational Research; 4) our longstanding commitment to recruit and train investigators from diverse clinical disciplines who are under-represented minorities or women. Our multidisciplinary, inter-institutional mentors will train four future academic leaders in Pediatric Hematology and Transfusion Medicine, who will lead both clinical and translational research teams, compete successfully for grant support and provide novel insights into the causes, pathophysiology and treatment of pediatric diseases that affect the Nation's children.

描述（由申请人提供）：在儿科输血医学和血液学领域开展高质量和变革性研究因若干障碍而变得复杂，包括：1）缺乏用于研究培训和实施的强大基础设施； 2）缺乏担任研究导师的中高级研究人员； 3）需要多学科转化方法来回答关键的临床问题； 4）临床和转化研究人员在少数群体地位和性别方面缺乏多样性，尽管患有疾病和失调的少数婴儿和儿童的代表性不足，可以从此类调查中受益。我们利用此应用程序为儿科输血医学和血液学领域的未来科学家提出一个高度协作、多学科、跨机构的指导培训计划，以解决这些障碍。它将专注于推进血液学、心血管和肺部疾病、输血和移植的诊断和临床管理方面的临床和转化学术。该项目名为儿科血液学和输血医学多学科研究培训奖（PHTMMRT），其长期目标是为来自不同背景的学员做好学术领导和独立资助的研究职业的准备。该项目的每位学员将在乔治华盛顿大学医学与健康科学学院 (GWU) 完成临床和转化科学 (MsCTR) 硕士学位，并将在多学科导师团队的共同监督下设计、实施和完成一个研究项目。三年计划完成后，每位学员将至少在一次全国研究会议上展示其数据，起草并提交一份或多份适合外部同行评审出版物的手稿，并向 NIH 提交外部资助申请或同等资金来源。该项目将由两位高素质且由 NIH 资助的首席研究员/项目总监 (PI/PD) 监督，他们具有独特且互补的临床背景和研究专业知识。他们将得到国家儿童医院及其附属的 GWU 医学与健康科学学院 (GWU) 的 9 名教员的支持，以及 9 名外部导师的支持，他们是在凝血、输血医学、移植、镰状细胞病和血管生物学方面具有专业知识的研究科学家。多样性增强官员是一名正教授和受资助的调查员，将协助招募少数族裔、残疾人或弱势申请人以及女性。最后，由 6 位 NIH 资助的输血医学和血液学领域的国家领导人组成的外部咨询委员会（已建立职业指导计划）将就 PHTMMRT 计划的发展和学员的进步提供年度反馈和指导。 PHTMMRT 计划将通过利用国家儿童基金会 (CNMC) 的多项现有优势以及与 NIH、美国红十字会、FDA 和霍华德大学医学院等邻近研究机构的合作，直接解决上述每个障碍。培训机会。这些优势包括 1.a) 拥有从机械研究到卫生服务研究等各个领域的转化和临床科学家； 1.b) 一批经验丰富的 NIH 资助教师，他们与我们的外部导师一起提供无与伦比的核心设施和研究培训； 2) 我们由 K 学者和其他受训者组成的大型本地社区，将通过受训者委员会提供团队科学方面的学院式、正式和非正式、跨学科的学习机会； 3) 我们由 CTSA 资助的强大基础设施，用于支持实习生研究，包括临床和转化研究硕士学位； 4) 我们长期致力于招募和培训来自不同临床学科、代表性不足的少数族裔或女性的研究人员。我们的多学科、跨机构导师将培训四位未来儿科血液学和输血医学领域的学术带头人，他们将领导临床和转化研究团队，成功竞争拨款支持，并就儿科疾病的病因、病理生理学和治疗提供新颖的见解，影响着国家的孩子们。