Understanding Ethnic Differences in Cancer: The Multiethnic Cohort Study

了解癌症的种族差异：多种族队列研究

基本信息

批准号：
8918518
负责人：
Christopher Alan Haiman
金额：
$ 387.92万
依托单位：
UNIVERSITY OF HAWAII AT MANOA
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-01 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8918518
关键词：
African American Area Biological Markers Blood Breast California Cancer Etiology Caring Caucasians Chronic Disease Cohort Studies Collection Colorectal Colorectal Cancer Communities Complex Computers Cultural Diversity DNA Data Data Analyses Databases Diet Disease Early Diagnosis Early treatment Environmental Risk Factor Ethnic group Exposure to Folic Acid Food Supplements Genetic Genetic Markers Genetic Risk Genotype Geographic Locations Goals Grant Hawaii Hawaiian population Head Health Hormone use Hour Individual Instruction Intake Japanese American Joints Latino Leadership Lymphocyte Maintenance Malignant Neoplasms Malignant neoplasm of lung Malignant neoplasm of ovary Measures Medical Methodology Minority Monitor Normal tissue morphology Nutrient Nutritional Obesity Outcome Paper Participant Pattern Population Postdoctoral Fellow Prevention Prostate Publishing Questionnaires Research Research Infrastructure Research Personnel Research Project Grants Resources Risk Risk Factors Saliva Selenium Specimen Students System Training Underserved Population Update Urine Vitamin E Woman Women&apos s Health Work biobank cancer risk cancer site cohort data management data sharing design disorder risk ethnic difference follow-up genetic epidemiology genetic variant genome wide association study improved insight malignant breast neoplasm men nutrition nutritional epidemiology programs prospective racial and ethnic racial and ethnic disparities repository tumor willingness

项目摘要

DESCRIPTION (provided by applicant): This application seeks support for the infrastructure of the Multiethnic Cohort (MEC) Study, which was established in Hawaii and southern California between 1993 and 1996 to study risk factors for cancer and other chronic diseases. The study was designed to take advantage of the ethnic and cultural diversity of the two geographic areas, as well as the expertise of the senior investigators in nutrition, ethnic/racial studies, and, subsequently, genetics. It is the most ethnically heterogeneous cancer cohort in existence. At baseline, the cohort included information on 215,000 men and women, comprised, by design, almost entirely of five ethnic/racial populations: Caucasians, Japanese Americans, Native Hawaiians, African Americans, and Latinos. The resource was later expanded to include a prospective bio repository of blood and urine specimens from ~ 70,000 of the participants. Leadership of the MEC entails a highly interactive, team approach; and the investigators have amply demonstrated their willingness to share data and participate actively in consortium projects. This application describes our aims over the next five years for maintaining and enhancing the infrastructure of the MEC, as well as plans for methodological research in the areas of genetic and nutritional epidemiology that utilize the resources of the cohort. Research accomplishments to date include significant contributions to understanding both genetic and environmental risk factors for cancer, particularly related to breast, prostate, colorectal and lun cancers. Nearly 250 papers describing these findings have been published. In addition, primarily over the last 20 years, more than 50 research grants have been built around the MEC, and more than 50 students and postdoctoral fellows have been trained on the study. This new grant will make possible the continuation of a well-integrated program of research aimed at evaluating environmental factors and genetic variants as risk factors for cancer and other common chronic diseases.

描述（由申请人提供）：本申请寻求对多种族队列 (MEC) 研究基础设施的支持，该研究于 1993 年至 1996 年间在夏威夷和南加州建立，旨在研究癌症和其他慢性疾病的风险因素。该研究旨在利用两个地理区域的民族和文化多样性，以及高级研究人员在营养、民族/种族研究以及随后的遗传学方面的专业知识。这是现有的种族异质性最强的癌症队列。在基线时，该队列包含 215,000 名男性和女性的信息，按照设计，他们几乎全部由五个民族/种族人口组成：白种人、日裔美国人、夏威夷原住民、非裔美国人和拉丁裔。该资源后来扩展到包括来自约 70,000 名参与者的血液和尿液样本的前瞻性生物储存库。 MEC 的领导需要高度互动的团队方法；研究人员充分表明了共享数据和积极参与联合体项目的意愿。该申请描述了我们未来五年维护和加强 MEC 基础设施的目标，以及利用队列资源在遗传和营养流行病学领域进行方法学研究的计划。迄今为止的研究成果包括对了解癌症的遗传和环境风险因素做出了重大贡献，特别是与乳腺癌、前列腺癌、结直肠癌和肺癌相关的风险因素。已发表近 250 篇描述这些发现的论文。此外，主要是在过去 20 年里，围绕 MEC 设立了 50 多项研究资助，并有 50 多名学生和博士后研究员接受了该研究的培训。这笔新拨款将使一项综合研究计划得以继续，该计划旨在评估环境因素和遗传变异作为癌症和其他常见慢性疾病的危险因素。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

22nd European Congress on Obesity (ECO2015), Prague, Czech Republic, May 6-9, 2015: Abstracts.

第 22 届欧洲肥胖大会 (ECO2015)，捷克共和国布拉格，2015 年 5 月 6-9 日：摘要。

DOI：
10.1159/000382140
发表时间：
2015
期刊：
Obesity facts
影响因子：
3.6
作者：
通讯作者：

Reply to investigating the relationship between vitamin d and cancer requires dosing the bioavailable nonhydroxylated vitamin d storage in cancer tissues.

DOI：
10.1002/cncr.29450
发表时间：
2015-09-15
期刊：
Cancer
影响因子：
6.2
作者：
Shui IM;Giovannucci E
通讯作者：
Giovannucci E

Factors associated with oxidative stress and cancer risk in the Breast and Prostate Cancer Cohort Consortium.

DOI：
10.3109/10715762.2013.875168
发表时间：
2014-03
期刊：
Free radical research
影响因子：
3.3
作者：
Blein S;Berndt S;Joshi AD;Campa D;Ziegler RG;Riboli E;Cox DG;NCI Breast and Prostate Cancer Cohort Consortium
通讯作者：
NCI Breast and Prostate Cancer Cohort Consortium

The contribution of rare variation to prostate cancer heritability.

DOI：
10.1038/ng.3446
发表时间：
2016-01
期刊：
Nature genetics
影响因子：
30.8
作者：
Mancuso N;Rohland N;Rand KA;Tandon A;Allen A;Quinque D;Mallick S;Li H;Stram A;Sheng X;Kote-Jarai Z;Easton DF;Eeles RA;PRACTICAL consortium;Le Marchand L;Lubwama A;Stram D;Watya S;Conti DV;Henderson B;Haiman CA;Pasaniuc B;Reich D
通讯作者：
Reich D

Variation in levels of the lung carcinogen NNAL and its glucuronides in the urine of cigarette smokers from five ethnic groups with differing risks for lung cancer.