Purchase of Laminar Flow Workstations and Biosafety Cabinets to Protect Personnel and Animals

购买层流工作站和生物安全柜以保护人员和动物

• 批准号: 9119453
• 负责人: Debra L Hickman
• 金额: $ 32.51万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-15 至 2017-03-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9119453
• 关键词: Allergens; Animal Housing; Animal Model; Animals; Applications Grants; Biological; Biomedical Research; Diabetes Mellitus; Ensure; Evaluation; Exposure to; Funding; Health; Housing; Human Resources; Indiana; Institution; Laboratory Animals; Malignant Neoplasms; Population; Rattus; Research; Resources; Rodent; Safety; Schools; Scientist; Universities; animal facility; animal resource; base; improved; medical schools; prevent

 DESCRIPTION (provided by applicant): As is consistent with the majority of institutions performing biomedical research, rodents are the most commonly used species of animal housed at the Indiana University School of Medicine (IUSM) Laboratory Animal Resource Center (LARC). These animals are critical for the School's major research focuses, including studies of cancer, diabetes, and other health problems of importance in the USA. To ensure adequate bioprotection and prevent personnel exposure to allergens, these rodents are generally housed in individually ventilated caging and handled in laminar flow animal transfer stations. Recent internal and external evaluations have determined that we need to upgrade and expand the number of laminar flow animal transfer stations and biological safety cabinets in use in the animal facilities to improve protection of personnel and animals. Specifically, we (1) identified a subset of existing laminar flow animal transfer stations that are not providing appropriate personnel protection; (2) identified an increase in the demand for housing rodents in ABSL2 housing; and (3) determined that we should transition our the majority of our rat colonies from conventional housing to individually ventilated caging. Additionally, we have identified animal rooms where the provision of multiple laminar flow animal transfer stations will enhance compliance with the use of proper protection of animals and personnel. Based on the findings from this evaluation of our resources, funds from this grant proposal will be used to purchase 29 animal transfer change stations and 8 biological safety cabinets. This purchase will allow us to replace the 26 inappropriate hoods, add capacity for the support of BSL2 level animal models, improve the bioprotection for our rat colonies, and allow the placement of multiple animal change stations rooms with large populations of animals and scientists to ensure proper protection of the rodents and personnel.

 描述（由申请人提供）：与大多数进行生物医学研究的机构一致，啮齿类动物是印第安纳大学医学院 (IUSM) 实验动物资源中心 (LARC) 中最常用的动物种类。对学院的主要研究重点至关重要，包括癌症、糖尿病和美国其他重要健康问题的研究。为了确保充分的生物保护并防止人员接触过敏原，这些啮齿动物通常被安置在单独通风的环境中。最近的内部和外部评估确定我们需要升级和扩大动物设施中使用的层流动物转运站和生物安全柜的数量，以加强对人员和动物的保护。我们发现，(1) 部分现有的层流动物转运站没有提供适当的人员保护；(2) 发现对专门用于 ABSL2 住房的啮齿动物的需求有所增加；(3) 决定我们应该转变我们的动物转运站。我们大多数的老鼠群体此外，根据对我们资源的评估结果，我们确定了动物房，其中提供多个层流动物转运站将增强对动物和人员的适当保护。该赠款提案的资金将用于购买 29 个动物转运更换站和 8 个生物安全柜。此次购买将使我们能够更换 26 个不合适的头罩，增加支持 BSL2 级动物模型的能力，改善对我们的大鼠的生物保护。群体，并允许放置多个动物换尿站房间，其中有大量动物和科学家，以确保对啮齿动物和人员的适当保护。