Retrofit MRLB LARC Caging for Automatic Watering System

用于自动浇水系统的 MRLB LARC 改造笼具

• 批准号: 7855692
• 负责人: Debra L Hickman
• 金额: $ 49.14万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7855692
• 关键词: AIDS/HIV problem; Animals; Applications Grants; Area; Diabetes Mellitus; Equipment; Funding; Genetically Engineered Mouse; Growth; Housing; Human Resources; Indiana; Injury; Laboratories; Laboratory Animals; Malignant Neoplasms; Medical Research; Osmosis; Plumbing; Research; Resources; Rodent; Schools; Scientist; System; Universities; Water; Water Purification; animal care; animal resource; cost; design; ergonomics; improved; medical schools

DESCRIPTION (provided by applicant): In recent years, the Indiana University School of Medicine (IUSM) has sustained a substantial increase in the use of genetically engineered mice (GEM). These animals are critical for the School's designated areas of major research growth, including cancer, diabetes, and HIV/AIDS. As a result of this growth in the use of GEM and the recent completion of new laboratory space for many of the scientists who conduct research involving these animals, we need to create more efficient and larger housing capacity for their use in IUSM's Laboratory Animal Resource Center (LARC). In 2007, institutional resources permitted the installation of a reverse osmosis water purification system in the Medical Research and Laboratory Building (MRLB), one of IUSM's major LARC facilities. Although this single unit was designed at a capacity to serve the entire MRLB rodent housing area, the automatic watering system plumbing could only be installed in one suite of the facility. Funds from the current grant proposal will be used to purchase the equipment necessary to deliver purified water to individually ventilated cages throughout the remainder of the rodent housing space in the MRLB via the automatic watering system. This will enable IUSM to improve efficient use of personnel and to reduce the operational costs associated with LARC facilities while maintaining the highest level of animal care possible. It also will allow IUSM to protect LARC animal staff by reducing the potential for ergonomic injuries associated with the use of water bottles.

描述（由申请人提供）：近年来，印第安纳大学医学院（IUSM）对基因工程小鼠（GEM）的使用持续大幅增加。这些动物对于学院指定的主要研究发展领域至关重要，包括癌症、糖尿病和艾滋病毒/艾滋病。由于 GEM 使用量的增长以及最近为许多进行涉及这些动物的研究的科学家建造的新实验室空间，我们需要在 IUSM 的实验动物资源中心为它们的使用创造更高效和更大的住房空间（拉克）。 2007 年，机构资源允许在医学研究和实验室大楼 (MRLB)（IUSM 的主要 LARC 设施之一）安装反渗透水净化系统。尽管这个单一装置的设计能力可以为整个 MRLB 啮齿动物居住区提供服务，但自动浇水系统管道只能安装在设施的一套套件中。当前拨款提案的资金将用于购买必要的设备，通过自动浇水系统将纯净水输送到 MRLB 其余啮齿动物饲养空间内的独立通风笼子。这将使 IUSM 能够提高人员的使用效率并降低与 LARC 设施相关的运营成本，同时保持尽可能高的动物护理水平。它还将使 IUSM 能够减少与使用水瓶相关的人体工程学伤害的可能性，从而保护 LARC 动物工作人员。