Antiviral host defense through selective translational inhibition

通过选择性翻译抑制进行抗病毒宿主防御

• 批准号: 8473888
• 负责人: MICHAEL DAVID
• 金额: $ 28.42万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-06-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8473888
• 关键词: AIDS/HIV problem; ATP phosphohydrolase; Affect; Alternative Splicing; Anti-Retroviral Agents; Antigens; Antiviral Agents; Antiviral Response; Area; Attenuated; Binding; Biogenesis; Biological Process; Caenorhabditis elegans; Cells; Charge; Codon Nucleotides; Communicable Diseases; DNA; Development; Diagnostic; Disease; Dominant-Negative Mutation; Drosophila genus; ERG gene; Employee Strikes; Event; Family; Generations; Genes; Genetic Transcription; Goals; HIV; HIV Infections; Homologous Gene; Host Defense; Human; IRF3 gene; Immune response; Infection; Infection prevention; Influenza; Interferon-alpha; Interferon-beta; Interferons; Kinetics; Length; Light; Location; Mediating; Messenger RNA; Molecular; Molecular Mechanisms of Action; Multi-Drug Resistance; Mus; N-terminal; Nucleic Acid Binding; Organism; Pathway interactions; Pharmaceutical Preparations; Positioning Attribute; Poxviridae; Process; Production; Protein Binding; Protein Biosynthesis; Protein Inhibition; Protein Isoforms; Protein Synthesis Inhibition; Proteins; RNA Helicase; Reporting; Retroviridae; Reverse Transcription; Role; Shapes; Specificity; Staging; System; Testing; Therapeutic; Therapeutic Intervention; Transfer RNA; Translational Repression; Viral; Viral Proteins; Virus; Yeasts; base; member; microbial; novel; pathogen; preference; prognostic; prospective; protein expression; protein function; tool; viral RNA

DESCRIPTION (provided by applicant): HIV continues to be one of the most prevalent infectious diseases in this world. Our discovery of a novel cellular factor that inhibits the production of HIV by infected cells provides a new target for the development of a novel class of anti-viral drugs and may additionally carry diagnostic and prognostic value. Furthermore, based on the molecular basis of the antiviral activity we hypothesize that other viruses such as Influenza will also be subject to inhibition by huSlfn11.

描述（由申请人提供）：艾滋病毒仍然是世界上最流行的传染病之一。我们发现了一种抑制受感染细胞产生艾滋病毒的新型细胞因子，为开发一类新型抗病毒药物提供了新的靶点，并且可能还具有诊断和预后价值。此外，根据抗病毒活性的分子基础，我们假设流感等其他病毒也会受到 huSlfn11 的抑制。