Incorporation of Zinc and Nickel Complexes that Bind H2S and HS in ChemFET Sensing Devices

在 ChemFET 传感器件中结合结合 H2S 和 HS 的锌和镍络合物

• 批准号: 10231809
• 负责人: Tobias J Sherbow
• 金额: $ 6.64万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10231809
• 关键词: Acidity; Address; Affinity; Amines; Anions; Architecture; Bicarbonates; Binding; Biological; Biomedical Research; Biomimetics; Buffers; Carbon Monoxide; Chemicals; Chemistry; Chlorides; Complex; Coupled; Data; Detection; Development; Devices; Educational workshop; Electrons; Elements; Enrollment; Environment; Environmental Monitoring; Exhibits; Faculty; Formulation; Gases; Goals; Hydrocarbons; Hydrogen Sulfide; Industry; Institutes; Interdisciplinary Study; Laboratories; Learning; Ligands; Market Research; Measures; Medical Research; Metals; Methods; Modification; Molecular; Molecular Biology; Monitor; Natural Gas; Nickel; Nitric Oxide; Occupations; Petroleum; Pharmacology; Physiological; Play; Polymers; Porphyrins; Postdoctoral Fellow; Prevalence; Production; Property; Research; Research Personnel; Research Proposals; Role; Running; Sampling; Science; Scientist; Source; Spectrum Analysis; Structure; System; Testing; Time; Titrations; Toxic effect; Transistors; Transition Elements; United States; Water; Work; Zinc; Zn(II)-phthalocyanine; analog; aqueous; base; career; design; detection limit; detection sensitivity; expectation; experience; improved; innovation; inorganic phosphate; lens; materials science; member; metal complex; molecular recognition; new technology; novel strategies; programs; protonation; response; sensor; sensor technology; small molecule

Project Summary/Abstract Hydrogen sulfide (H2S) is an important analytical target for sensing applications in diverse settings, including the environment, biomedical sciences, and petroleum and natural gas industries. Preliminary results from my work in the Pluth/Johnson laboratories has established the feasibility of using ChemFET architectures to detect hydrosulfide (HS–) anion in aqueous solution. This approach leverages the detection of HS–, which is the most prevalent protonation state of H2S under physiological conditions, by direct molecular recognition. Although these preliminary results provide the first example of detecting HS– with a ChemFET, the initial limit of detection (LoD) of 8 mM is currently only applicable in the natural gas industry; significantly lower detection limits are needed for environmental monitoring or in biological settings. In order to improve the applicability of these HS– sensing devices I will build new recognition elements in the ChemFET platform. The key innovative element of this research proposal is to further develop H2S and HS– recognition chemistry by using a new approach of synthesizing molecular metal complexes that have strong binding interactions with H2S and HS– and incorporating them into ChemFET architectures that have proven to show concertation dependent responses to HS– in aqueous solution. My extensive experience as a synthetic inorganic chemist coupled with my experience as a post-doctoral researcher that has developed ChemFETs to sense a variety of analytes prepares me well to develop new technologies for H2S or HS– detection. In addition to the proposed research and as part of my professional development to advance my career goals of building a start-up company or working in industry, I am excited to enroll and continue to participate in the Lens of the Market (LOTM) workshop. LOTM is a three-stage program designed for scientists to learn about the value of research in addressing the challenges faced by people in the real world. It also aims to provide networking for job and career opportunities. I will perform market research in the field of sensing to pair sensing technologies with specific market needs. I have completed stages one and two of the LOTM program and I will continue on to stage three. Lastly, the environment in which the research will be performed is an interdisciplinary research environment. I interact regularly with my sponsor and cosponsor who are experts in the field of sensing, supramolecular chemistry, small molecule binding in metal complexes and hydrogen sulfide related chemistry. Many faculty members, including Profs. Pluth and Johnson (sponsors), are members of cross-department institutes, such as the Materials Science Institute, Knight Campus for Accelerating Scientific Impact, and the Institute of Molecular Biology, which provides me with an additional breadth of interactions.

项目摘要/摘要 硫化氢（H2S）是在潜水员环境中传感应用的重要分析目标，包括 环境，生物医学科学，石油和天然气行业。我的初步结果 Pluth/Johnson实验室的工作已经确定了使用Chemfet体系结构检测的可行性 水溶液中的氢硫化物（HS-）阴离子。这种方法利用了HS的检测，这是最多的 通过直接分子识别，在生理条件下H2s的普遍质子化状态。虽然这些 初步结果提供了检测HS的第一个示例 - 用化学FET，最初的检测限制（LOD）。 目前仅适用于天然气行业8毫米；需要明显较低的检测限制 环境监测或生物环境中。为了提高这些HS - 传感器的适用性 设备我将在ChemFet平台中构建新的识别元素。关键的创新元素 研究建议是通过使用一种新方法来进一步开发H2和HS - 识别化学 合成的分子金属络合物，与H2S和HS –和HS和 将它们纳入Chemfet架构中 HS - 在水溶液中。我作为合成无机化学家的丰富经验以及我的经验 作为博士后研究人员，已经开发了化学素养来感知各种分析物，这为我做好了很好的准备 开发用于H2S或HS检测的新技术。 除了拟议的研究以及作为我的专业发展的一部分，以促进我的职业目标 在建立一家初创公司或在行业工作中，我很高兴能够参加并继续参加 市场镜头（LOTM）研讨会。 Lotm是一个三阶段的计划，旨在科学家了解 研究在解决现实世界中人们面临的挑战方面的价值。它还旨在提供 建立工作和职业机会的网络。我将在对配对传感器的敏感性领域进行市场研究 有特定市场需求的技术。我已经完成了LOTM计划的第一和两个阶段，我将 继续进入第三阶段。 最后，进行研究的环境是跨学科的研究环境。 我定期与赞助商和合作伙伴互动，他们是感应，超分子领域的专家 化学，金属络合物和硫化氢相关的化学中的小分子结合。许多教师 会员，包括教授。 Pluth和Johnson（赞助商）是跨部门机构的成员，例如 材料科学研究所，骑士校园加速科学影响，分子研究所 生物学，这为我提供了额外的互动广度。