Development of New Hemostatic Dressings

新型止血敷料的研制

基本信息

批准号：
7670536
负责人：
Ruben Spretz
金额：
$ 20万
依托单位：
LNKCHEMSOLUTIONS
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-08-01 至 2011-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7670536
关键词：
Academic Medical Centers Animal Model Animal Testing Animals Back Bandage Behavior Biochemistry Biological Biomedical Engineering Blood Blood Clot Blood Coagulation Factor Blood coagulation Categories Cattle Classification Coagulation Process Collaborations Development Devices Drug Formulations Engineering FDA approved Family suidae Fibrin Tissue Adhesive Foundations Generations Goals Hemorrhage Hemostatic Agents Hemostatic function Human In Vitro Injury International Investigation Kinetics Lead Letters Marketing Mechanics Medical center Military Personnel Modeling Nanostructures Nanotechnology Nebraska Operative Surgical Procedures Performance Phase Plants Plasma Pliability Price Process Production Property Proteins Recombinants Red Cross Research Research Personnel Resistance Resources Route Running Sampling Scientist Small Business Innovation Research Grant Solutions Staging Sterile coverings Structure Surgeon Temperature Testing Thrombelastography Thrombin Toxic effect Universities Vicryl Work Yeasts animal data base biocompatible polymer biomaterial compatibility cost design experience femoral artery implantable device improved in vitro Model in vitro testing in vivo multidisciplinary nano nanostructured novel poly(lactide)public health relevance reconstitution research and development scaffold stem success validation studies

项目摘要

DESCRIPTION (provided by applicant): A multidisciplinary team of researchers seeks to develop novel and economically feasible implantable hemostatic dressings for severe (e.g. arterial) bleeding. Key features of the device under development are its excellent pliability, biocompatibility, and nano/microengineered structure to maximize performance without requiring excessive amounts of procoagulants. LNKChemsolutions LLC and its academic partners will conduct in vitro (e.g., thromboelastography) and in vivo validation studies using a swine model, and focus initially on bandage formulations that are most likely to experience only modest to reasonable regulatory resistance. Long term goals focus on developing partnerships with national and international partners with animal, yeast and/or plant expression platforms for recombinant clotting factors. PUBLIC HEALTH RELEVANCE: This SBIR proposal is a multidisciplinary effort to develop new implantable dressings for hemorrhage control, with emphasis on treatment of severe arterial bleeding situations. Both the civilian and military markets will greatly benefit from important advances in the field.

描述（由申请人提供）：一个多学科的研究人员旨在开发新颖且在经济上可行的可植入式止血敷料，以使其用于严重（例如动脉）出血。正在开发的设备的关键特征是其出色的柔韧性，生物相容性和纳米/微工程结构，以最大程度地提高性能，而无需过多量的proco剂。 Lnkchemsolutions LLC及其学术伙伴将在体外（例如血栓射击学）和使用猪模型进行体内验证研究，最初专注于最有可能仅体验到适度至合理的监管耐药性的绷带配方。长期目标的重点是与国家和国际合作伙伴建立与动物，酵母和/或植物表达平台的合作伙伴关系，以进行重组凝血因素。公共卫生相关性：该SBIR提案是一项多学科的努力，旨在开发新的可植入敷料以进行出血控制，重点是治疗严重的动脉出血情况。平民和军事市场都将从该领域的重要进展中受益匪浅。