NHLBI Pediatric Translational Consortium Administrative Coordinating Center

NHLBI 儿科转化联盟行政协调中心

• 批准号: 8424991
• 负责人: SHARON L TENNSTEDT
• 金额: $ 875.66万
• 依托单位: NEW ENGLAND RESEARCH INSTITUTES, INC.
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2016-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8424991
• 关键词: Address; Advisory Committees; Area; Basic Science; Bioinformatics; Cardiac; Cardiology; Cardiovascular Diseases; Case Report Form; Certification; Childhood; Clinic; Clinical; Clinical Research; Clinical Trials; Collaborations; Communication; Complex; Conduct Clinical Trials; Congenital Heart Defects; Consent Forms; Data; Data Coordinating Center; Data Quality; Databases; Development; Electronic Mail; Electronics; Environment; Fostering; Funding; Genetic; Genomics; Goals; Heart; Human; Image; Information Systems; Instruction; Laboratories; Lead; Leadership; Mails; Maintenance; Methodology; Molecular; Monitor; National Heart, Lung, and Blood Institute; Pathway interactions; Persons; Physiological; Preparation; Principal Investigator; Probability; Procedures; Process; Program Development; Protocols documentation; Qualifying; Quality Control; Recording of previous events; Relative (related person); Reporting; Research; Research Personnel; Research Support; Resources; Role; Schedule; Scientist; Services; Sum; Teleconferences; Telephone; Training; Translational Research; Translations; Work; data management; design; experience; innovation; meetings; member; payment; programs; symposium; web site

DESCRIPTION (provided by applicant): The NHLBI Translational Program in Pediatric Cardiovascular Disease will encourage and facilitate translation of results from basic science to clinical research and to provide clinic input to needs for basic research. The Program will consist of the Pediatric Cardiac Genomics Consortium and the Cardiac Development Consortium supported by the Administrative Coordinating Center (ACC). Each Consortium will function independently but will interact with each other as well as with the NHLBI Pediatric Heart Network. Key areas of ACC responsibility and function include provision of logistical and support services; management and distribution of Consortia funds to support Research Cores; and provision of electronic information and communication services. In addition, study activities in the Pediatric Cardiac Genomics Consortium will be supported by the PHN DCC, i.e. harmonization of protocols and consent forms across the Consortium, development and programming of case report forms; training and certification of Research Center staff in conduct of Consortium studies, management of clinical research data, and quality control activities. NERI is uniquely qualified to serve as the ACC for this initiative. Most relevant, NERI has served most effectively as the Pediatric Heart Network Data Coordinating Center (PHN DCC) since its inception in 2001. NERI's contributions to the PHN have been significant and varies has encompass numerous administrative accomplishments that are highly relevant to the ACC, as well as other scientific, statistical, and technical accomplishments. The proposed leadership of the ACC consists of key investigators with the same leadership roles in the PHN DCC who will bring extensive, directly related, and highly complementary administrative, research and clinical experience in pediatric cardiology. NERI has a long history of coordinating center work (31 DCCs) that has allowed for greater efficiency and sharing of approaches for administrative procedures unique to clinical research networks as well as innovative data management, development of public and administrative websites, and methodologies for designing and analyzing clinical studies and trials and complex longitudinal data. In sum, NERI's scientific environment contributes substantially to the probability of successful completion of the activities of this Translational Program in Pediatric Cardiovascular Disease, including successful alignment with the Pediatric Heart Network. RELEVANCE (See instructions): The NHLBI translational program in pediatric cardiovascular disease consists of two research consortia whose work will lead to enhanced understanding of the molecular, cellular, and physiologic mechanisms responsible for healthy development and the relative contribution of genetic influences to the formation of cardiac defects in humans. Collaboration and integration of the work of the NHLBI Pediatric Heart Network will provide the pathway for the translation of research findings from these two Consortia to the conduct of clinical trials.

描述（由申请人提供）： NHLBI 儿科心血管疾病转化计划将鼓励和促进基础科学成果向临床研究的转化，并为基础研究的需求提供临床投入。该计划将由行政协调中心 (ACC) 支持的儿科心脏基因组学联盟和心脏发展联盟组成。每个联盟将独立运作，但会相互互动以及与 NHLBI 儿科心脏网络互动。 ACC 职责和职能的关键领域包括提供后勤和支持服务；管理和分配财团资金以支持研究核心；以及提供电子信息和通信服务。此外，儿科心脏基因组学联盟的研究活动将得到 PHN DCC 的支持，即协调整个联盟的方案和同意书、病例报告表的开发和编程；对研究中心工作人员进行联合研究、临床研究数据管理和质量控制活动的培训和认证。 NERI 是唯一有资格担任该计划的 ACC 的人。最相关的是，NERI 自 2001 年成立以来一直作为儿科心脏网络数据协调中心 (PHN DCC) 发挥着最有效的作用。NERI 对 PHN 的贡献是巨大的，并且涵盖了与 ACC 高度相关的许多行政成就，例如以及其他科学、统计和技术成就。拟议的 ACC 领导层由与 PHN DCC 具有相同领导角色的关键研究人员组成，他们将带来儿科心脏病学方面广泛、直接相关且高度互补的管理、研究和临床经验。 NERI 在协调中心工作（31 个 DCC）方面有着悠久的历史，它可以提高效率并共享临床研究网络特有的管理程序方法以及创新的数据管理、公共和管理网站的开发以及设计和管理方法。分析临床研究和试验以及复杂的纵向数据。总之，NERI 的科学环境对成功完成儿科心血管疾病转化计划活动的可能性做出了重大贡献，包括与儿科心脏网络的成功协调。相关性（参见说明）：NHLBI 儿科心血管疾病转化计划由两个研究联盟组成，其工作将加深对负责健康发育的分子、细胞和生理机制的理解，以及遗传影响对形成心血管疾病的相对贡献。人类心脏缺陷。 NHLBI 儿科心脏网络工作的合作和整合将为这两个联盟的研究成果转化为临床试验的开展提供途径。