Limited Access Dataset: ACTIVE Study Phase II

有限访问数据集：ACTIVE 研究第二阶段

• 批准号: 7303693
• 负责人: SHARON L TENNSTEDT
• 金额: $ 5.74万
• 依托单位: NEW ENGLAND RESEARCH INSTITUTES, INC.
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7303693
• 关键词: Age; Aging; Alabama; Alzheimer' s Disease; Archives; Automobile Driving; Award; Boston; Brain; CD-ROM; Cognition; Cognitive; Daily; Data; Data Analyses; Data Set; Documentation; Effectiveness; Effectiveness of Interventions; Elderly; Enrollment; Ensure; Funding; Goals; Health; Indiana; Institution; Intervention; Maintenance; Measurement; Measures; Michigan; Modification; NIH Program Announcements; New England; Occupational activity of managing finances; Participant; Pennsylvania; Performance; Persons; Pharmaceutical Preparations; Phase II Clinical Trials; Privacy; Public Health; Randomized Controlled Trials; Reading; Rehabilitation Centers; Research Institute; Research Personnel; Risk; Site; Social Behavior; Staging; Testing; Training; Universities; Work; aged; cognitive function; computerized; food preparation; improved; instrument; instrumental activity of daily living; interest; size

DESCRIPTION (provided by applicant): The Aim of this R03 is to create Limited Access Datasets for the third and fifth annual assessments for the Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) trial, conducted from 1998-2001. Funds for this work were not included in the award for conduct of the trial. A previous R03 award (AG22338) funded the creation of the Limited Access Datasets for baseline, immediate post-test and first and second annual assessments. These datasets are being archived in two stages with the National Archive of Computerized Data in Aging (NACDA) at the University of Michigan (http://www.icpsr.umich.edu/NACDA). The Limited Access Dataset for the third and fifth annual assessments will be archived with NACDA as supplements to the initial dataset. This application is directly responsive to NIA's R03 Program Announcement PA-06-02 "Sociobehavioral Data Analysis and Archiving in Aging". ACTIVE was a randomized, controlled trial, sponsored by NIA and NINR, conducted at 6 field sites (University of Alabama-Birmingham; Hebrew Rehabilitation Center for the Aged, Boston; Indiana University; Johns Hopkins University; Pennsylvania State University; and Wayne State University. The primary objective was to test the effectiveness and durability of three cognitive interventions in improving elders' performance on basic measures of cognition and on measures of cognitively demanding daily activities (e.g., food preparation, driving, medication use, financial management). A total of 2,832 persons were enrolled in the trial. The five- year results of ACTIVE show durability of intervention effects on cognitive function and transfer of these effects to maintenance of IADL function. Because of its size and the carefully developed rigor, its datasets offer to investigators a wealth of opportunities for secondary analyses. Modifications will be made to ACTIVE datasets to ensure privacy protection for all ACTIVE participants and institutions. The reformatted datasets will be archived in read-only format on CD ROM and accompanied by all related measurement instruments, variable descriptions and summary tables, and comprehensive documentation. This work will be performed by the New England Research Institutes, the Coordinating Center for the trial. PROJECT NARRATIVE: The ACTIVE study has and will produce results of substantial public interest, public health significance, and scientific value. The ACTIVE interventions fit well into several nationwide health initiatives (e.g., NIH's "Healthy Brain" initiative, and the Alzheimer Association's "Maintain your Brain), with their goals of lowering risk for loss of independence. There has been a high level of interest in and use of the currently archived datasets by universities and investigators. This project will make the remainder of the study data available for public use.

描述（由申请人提供）：本 R03 的目的是为 1998 年至 2001 年进行的独立和重要老年人高级认知训练 (ACTIVE) 试验的第三次和第五次年度评估创建有限访问数据集。这项工作的资金不包括在进行试验的奖励中。之前的 R03 奖项 (AG22338) 资助创建有限访问数据集，用于基线、立即测试后以及第一次和第二次年度评估。这些数据集分两个阶段归档到密歇根大学国家老龄化计算机数据档案馆 (NACDA) (http://www.icpsr.umich.edu/NACDA)。第三次和第五次年度评估的有限访问数据集将作为初始数据集的补充与 NACDA 一起存档。该应用程序直接响应 NIA 的 R03 计划公告 PA-06-02“老龄化中的社会行为数据分析和归档”。 ACTIVE 是一项随机对照试验，由 NIA 和 NINR 赞助，在 6 个现场地点（阿拉巴马大学伯明翰分校、波士顿希伯来老年人康复中心、印第安纳大学、约翰霍普金斯大学、宾夕法尼亚州立大学和韦恩州立大学）进行主要目标是测试三种认知干预措施在改善老年人基本认知测量和认知要求日常活动（例如食物）表现方面的有效性和持久性。 ACTIVE 的五年结果显示，干预对认知功能的影响具有持久性，并且这些影响可转移到 IADL 功能的维持上。由于其规模和精心开发的严谨性，其数据集为研究人员提供了大量的二次分析机会，将对 ACTIVE 数据集进行修改，以确保所有 ACTIVE 参与者和机构的隐私保护。重新格式化的数据集将以只读格式存档在 CD ROM 上，并附有所有相关的测量仪器、变量描述和汇总表以及综合文档。这项工作将由试验协调中心新英格兰研究所进行。项目叙述：ACTIVE 研究已经并将产生具有重大公共利益、公共卫生意义和科学价值的结果。 ACTIVE 干预措施非常适合多项全国性健康倡议（例如，NIH 的“健康大脑”倡议和阿尔茨海默病协会的“维护你的大脑”），其目标是降低丧失独立性的风险。人们对大学和研究人员使用当前存档的数据集将使剩余的研究数据可供公众使用。