Core E:Training Core

核心E：培训核心

• 批准号: 9043077
• 负责人: Michael D McClean
• 金额: $ 19.92万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9043077
• 关键词: Bioinformatics; Biological; Biological Sciences; Biology; Boston; Cell physiology; Communication; Communities; Complex; Computational Biology; Computational Science; Data Set; Development; Discipline; Ecology; Elements; Endocrine; Environmental Health; Exposure to; Foundations; Future; General Population; Goals; Government Agencies; Hazardous Waste Sites; Health; Institution; Instruction; Journalism; Knowledge; Laboratories; Life; Medical; Methods; Mission; Molecular Models; National Institute of Environmental Health Sciences; New England; Organism; Pathway interactions; Poison; Postdoctoral Fellow; Predisposition; Program Research Project Grants; Public Health; Reproduction; Research; Resources; Risk; Running; Science; Scientist; Signal Recognition Particle; Students; Techniques; Toxicology; Training; Training Programs; Training Support; Universities; Work; Writing; Xenobiotics; analytical method; base; cohort; college; developmental toxicity; genome-wide; graduate student; high throughput analysis; laboratory experience; member; molecular modeling; peer; peer networks; podcast; posters; programs; receptor; reproductive toxicity; science museum; skills; superfund chemical

This application proposes that the BU SRP Training Core will continue to provide interdisciplinary training in laboratory science, bioinformatics and computational biology, while also expanding the Training Core to act as a common reference point for all graduate students and post-doctoral fellows who work within the BU SRP program (including those who are supported by other BU SRP projects, other related training programs, and directly by the Training Core). The Training Core will directly support two students a year in bioinformatics techniques applied to the laboratory sciences, with an emphasis on analysis of high throughput, genome-wide data sets and on molecular modeling. This focus responds to the strategic importance of these methods for the biology of the future, the relative lack of exposure to them in traditional laboratory training programs, and the unique resources ofthe applicant institution. A major element ofthe program theme, the susceptibility ofthe developing organism to low-level xenobiotic exposures through a variety of pathways, is ideally suited to be the context for this cross discipline training. After nomination by project PIs at the end of their first year of study, two students will be selected by a Steering Committee consisting ofthe Program Director, the Training Core Director, and two additional BUSRP PIs, contingent on their commitment to one of the laboratories within the BUSRP. These students will receive appropriate core courses covering bioinformatics, reproduction and development, environmental health, and toxicology during their training program. In addition, we focus on communication skills, not only within the scientific community but to disseminate scientific knowledge to the broader community and to close the "communication gap" between bench and laboratory science and the public at large. Importantly, the Training Core will orient graduate students and post-doctoral fellows supported by BU SRP projects or the Training Core to the mission, activities and needs of the NIEHS SRP, EPA and state environmental and health agencies; and thereby develop a sense of shared mission and peer network as they work towards advancing the science needed to provide a firm foundation for solving the complex health and environmental issues associated with the nation's hazardous waste sites.

该申请建议BU SRP培训核心将继续提供跨学科的培训 实验室科学，生物信息学和计算生物学，同时还扩大培训核心以行动 作为在BU中工作的所有研究生和博士后研究员的常见参考点 SRP计划（包括其他BU SRP项目支持的计划，其他相关培训计划， 直接通过训练核心）。培训核心将每年直接支持两名学生 生物信息学技术应用于实验室科学，重点是分析高 吞吐量，全基因组数据集和分子建模。这个重点回应战略 这些方法对于未来生物学的重要性，在传统中相对缺乏接触它们 实验室培训计划以及申请人机构的独特资源。一个主要要素 程序主题，发展有机体对低水平异生物的暴露的敏感性通过 多种途径非常适合进行这种跨学科训练的背景。提名之后 在学习第一年结束时，PIS项目将由指导委员会选出两名学生 由计划主管，培训核心主任和另外两个BUSRP PI组成，取决于 他们对BUSRP中的一个实验室的承诺。这些学生将获得适当的核心 涵盖生物信息学，生殖和发展，环境健康和毒理学的课程 他们的培训计划。此外，我们不仅关注科学界的沟通技巧 但是，将科学知识传播给更广泛的社区并缩小“沟通差距” 在替补席和实验室科学和整个公众之间。重要的是，训练核心将向东方 BU SRP项目或培训核心支持的研究生和博士后研究员 NIEHS SRP，EPA以及州环境与卫生机构的任务，活动和需求；和 因此，在他们努力推进科学的过程中发展出一种共同的使命和同伴网络的感觉 需要为解决与之相关的复杂健康和环境问题提供坚定的基础 国家的危险废物站点。