Prevalence, Predictors, and Consequences of Alcohol Use from Childhood to Midlife

从童年到中年饮酒的患病率、预测因素和后果

基本信息

批准号：
8451597
负责人：
JENNIFER L MAGGS
金额：
$ 53.83万
依托单位：
PENNSYLVANIA STATE UNIVERSITY, THE
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-04-15 至 2015-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8451597
关键词：
Address Adolescence Adolescent Adult Age Alcohol abuse Alcohol consumption Alcohol dependence Alcohol or Other Drugs use Alcohols Archives Attitude Birth British Buffers Capital Cardiovascular system Characteristics Child Child Development Childhood Cognition Cognitive Cohort Studies Communities Costs and Benefits Data Data Analyses Deposition Development Disease Epidemiology Equation Ethnic Origin Expectancy Family Family Policy Family health status Fathers Frequencies Funding Gender Health Health Policy Heavy Drinking Injury International Knowledge Lead Life Cycle Stages Life Style Light Link Long-Term Effects Longitudinal Surveys Measures Mediation Medical Methods Modeling Monozygotic Twinning Monozygotic twins Mothers Outcome Parenting behavior Parents Pathway interactions Patient Self-Report Pattern Peer Pressure Persons Population Prevalence Prevention Problem behavior Public Health Recommendation Recording of previous events Relative (related person)Religion Research Resource Sharing Resources Risk Risk Factors Role Sampling Schools Shapes Siblings Social Class Social Controls Social Policies Socialization Surveys Target Populations Temperament Testing Variant Work age group alcohol expectancy alcohol risk alcohol use disorder alcohol use initiation base binge drinking cohort design drinking early adolescence early alcohol use falls family influence improved intergenerational middle age programs prospective public health relevance social social capital success teacher theories underage drinking underage drinking reduction

项目摘要

DESCRIPTION (provided by applicant): Based on a life course developmental perspective, this application proposes to use primary and secondary longitudinal data from three ongoing nationally representative birth cohort studies (born 2001, 1970, 1958; each n >10,000) to examine prevalence, predictors, and consequences of alcohol use from early adolescence through midlife. Specific aims of this developmental epidemiological application are to: (1) Examine variation in the prevalence of early alcohol initiation by conducting the first prospective national study of early alcohol use and attitudes starting in the age 11 survey of the 2001 Millennium Cohort Study (MCS), and testing theory- based hypotheses about child temperamental, cognitive, and family influences on early alcohol use in the MCS and the 1970 British Cohort Study (BCS) with structural equation models; (2) In the BCS and 1958 National Child Development Study (NCDS), examine how changes in work, family, and civic social roles across adulthood predict fluctuations in alcohol use and problem drinking (Role Socialization hypothesis), using fixed effects models to control for stable unobserved effects; and (3) Document long-term consequences of alcohol use for health and social roles in midlife (age 38/50 in BCS/NCDS) using propensity score models. J-shaped associations are hypothesized in which light-to-moderate alcohol use (relative to abstaining and to heavy drinking) predicts greater midlife health and role success (Consequences hypothesis). Analyses addressing all aims will use multisource-parent, teacher, medical, cognitive, self- report-and multi-wave longitudinal data to control for child and adolescent social and personal capital (Selection hypothesis) and test whether observed effects are buffered for those with greater capital (Selection x Role Socialization, Selection x Consequences hypotheses). Funds are requested to add measures of lifetime alcohol initiation, frequency of use and binge drinking, maximum quantity, positive and negative alcohol expectancies, perceived risk, and perceived peer pressure to age 11 MCS surveys, and to conduct secondary data analyses using already- collected longitudinal data from birth to age 7 (MCS), age 38 (BCS), and age 50 (NCDS). Long- term, the project aims to follow the MCS cohort through adolescence and beyond and the BCS and NCDS cohorts into older adulthood (as pivotal social roles continue to change and alcohol use/abuse consequences accumulate) to document population and sub-population patterns, effects, and variation in vulnerability to heavy and problem drinking. Prospective national data on drinking patterns across the life course, with appropriate controls for potentially spurious risk and protective factors and for conditional effects, are vital for (a) identifying developmental antecedents of vulnerability, (b) understanding mechanisms and ruling out spurious effects, and (c) informing and tailoring developmentally-appropriate programs and public health recommendations designed to decrease harms of alcohol abuse and dependence including disease, injury, and social role problems.

描述（由申请人提供）：基于生命历程发展的角度，本申请建议使用来自三项正在进行的全国代表性出生队列研究（出生于 2001 年、1970 年、1958 年；每个 n > 10,000）的主要和次要纵向数据来检查患病率，从青春期早期到中年饮酒的预测因素和后果。这一发展流行病学应用的具体目标是： (1) 通过从 2001 年千年队列研究 (MCS) 的 11 岁调查开始，进行第一个关于早期饮酒和态度的前瞻性全国研究，检查早期饮酒流行率的变化，并用结构方程检验 MCS 和 1970 年英国队列研究 (BCS) 中关于儿童气质、认知和家庭对早期饮酒影响的基于理论的假设模型； (2) 在 BCS 和 1958 年国家儿童发展研究 (NCDS) 中，研究成年期间工作、家庭和公民社会角色的变化如何预测酒精使用和问题饮酒的波动（角色社会化假说），使用固定效应模型来控制对于稳定的未观察到的影响； (3) 使用倾向评分模型记录饮酒对中年（BCS/NCDS 中 38/50 岁）的健康和社会角色的长期影响。假设存在 J 形关联，其中轻度至中度饮酒（相对于戒酒和大量饮酒）可预测更佳的中年健康和角色成功（后果假设）。针对所有目标的分析将使用多源——家长、教师、医疗、认知、自我报告和多波纵向数据来控制儿童和青少年的社会和个人资本（选择假设），并测试观察到的影响是否对那些患有更大的资本（选择x角色社会化，选择x后果假设）。要求提供资金，在 11 岁 MCS 调查中添加终生饮酒开始、使用频率和酗酒、最大数量、积极和消极酒精预期、感知风险和感知同侪压力等指标，并使用已收集的数据进行二次数据分析。从出生到7岁（MCS）、38岁（BCS）和50岁（NCDS）的纵向数据。从长远来看，该项目的目标是跟踪 MCS 队列贯穿青春期及以后，以及 BCS 和 NCDS 队列进入老年期（随着关键社会角色的不断变化和酒精使用/滥用后果的累积），以记录人口和亚人口模式，影响以及对酗酒和问题饮酒的脆弱性的变化。关于整个生命周期饮酒模式的前瞻性国家数据，以及对潜在虚假风险和保护因素以及条件影响的适当控制，对于以下方面至关重要：(a) 确定脆弱性的发展前因；(b) 了解机制并排除虚假影响；以及(c) 提供信息并制定适合发展的计划和公共卫生建议，旨在减少酒精滥用和依赖的危害，包括疾病、伤害和社会角色问题。