California NeuroAIDS Tissue Network

加州神经艾滋病组织网络

• 批准号: 8657113
• 负责人: CRISTIAN L ACHIM
• 金额: $ 118.54万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-01 至 2018-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8657113
• 关键词: AIDS neuropathy; Acquired Immunodeficiency Syndrome; Address; Age-Years; Aging; Aliquot; Anti-Retroviral Agents; Antiviral Agents; Autopsy; Brain; California; Cessation of life; Collaborations; Collection; Communities; County; Data; Data Quality; Disease; Enrollment; Ensure; Epidemic; Funding; HIV; Highly Active Antiretroviral Therapy; Hour; Individual; International; Life; Link; Liquid substance; Medical center; Methods; Neurocognitive; Neurologic; Neuropsychology; Participant; Pathologic; Persons; Plasma; Positioning Attribute; Principal Investigator; Protocols documentation; Psychiatry; Qualifying; Recruitment Activity; Research; Research Personnel; Resources; Risk; Serum; Site; Specimen; Technical Expertise; Tissue Banking; Tissue Banks; Tissue Sample; Tissues; United States National Institutes of Health; Work; clinical research site; cohort; follow-up; human old age (65+); meetings; neurobehavioral; neuropathology; neuropsychological; public health relevance; quality assurance; response; success

DESCRIPTION (provided by applicant): This is a renewal application for the California NeuroAIDS Tissue Network (CNTN) in response to the RFA- MH-13-070. The overarching objective of the CNTN remains the same today as it was when it was first established in 1998: to serve as a tissue bank resource comprised of CNS autopsy material from HIV- infected individuals who are well characterized neuropsychological and neuromedically in life. The CNTN has been very successful in meeting this primary objective. To date, we have enrolled a total of 821 participants, including 303 autopsies, 39,600 aliquots of plasma, 27,500 aliquots of CSF, 18,700 aliquots of serum, and 5,600 aliquots of PBMCs. For the current application, we are restructuring our cohort to best target and obtain autopsies from high priority cases that are aligned with the three thematic priorities identified in the RFA: a) HIV eradication from CNS reservoirs; b) mechanisms of HIV-associated neurocognitive disorders (HAND) in the setting of long term HAART, and c) HIV and aging. Specifically, we will target continuation of HIV+ participants who 1) are at greatest risk for death, 2) have been on ART for more than 10 years, and are greater than 50 years of age, which will provide valuable cases to the NNTC resource that are aligned with the NIH three thematic priorities. Specifically, we will recruit a cohort of 4 older (65+ years old) participants from a new collaboration with the Eisenhower Medical Center (EMC) in Palm Springs given that more than 10% H1V+ persons in Riverside County are 65,or older. CNTN is an active participant in the National NeuroAIDS Tissue Consortium (NNTC), a partnership of four NIH-funded neuroAIDS tissue banks. CNTN contributes to the NNTC by: 1) leading the NNTC Neuropsychology and Psychiatry subcommittee and overseeing quality assurance for these data, 2) guiding the methods for historical antiretroviral collection, 3) contributing to the refinement of the common NNTC assessment and neuropathology protocols, 4) providing review and fulfillment of NNTC-wide tissue and sample requests, and 5) serving on the NNTC Steering Committee.. The CNTN will work closely with the NNTC to ensure continued success of this exceptional national and international resource for research on neuroAIDS.

描述（由申请人提供）：这是加州 NeuroAIDS 组织网络 (CNTN) 响应 RFA-MH-13-070 的更新申请。如今，CNTN 的总体目标与 1998 年首次建立时一样：作为一个组织库资源，由来自 HIV 感染者的中枢神经系统尸检材料组成，这些感染者在生活中具有良好的神经心理学和神经医学特征。 CNTN 在实现这一主要目标方面非常成功。迄今为止，我们共招募了 821 名参与者，包括 303 份尸检、39,600 份血浆、27,500 份脑脊液、18,700 份血清和 5,600 份 PBMC。对于当前的应用，我们正在重组我们的队列，以实现最佳目标，并从与 RFA 中确定的三个优先主题相一致的高优先级病例中获取尸检结果：a) 根除中枢神经系统储存库中的艾滋病毒； b) 长期 HAART 背景下 HIV 相关神经认知障碍 (HAND) 的机制，以及 c) HIV 和衰老。具体来说，我们将继续关注那些 1) 死亡风险最大、2) 接受 ART 超过 10 年且年龄超过 50 岁的 HIV+ 参与者，这将为 NNTC 资源提供有价值的案例，与 NIH 的三个优先主题保持一致。具体来说，鉴于河滨县超过 10% 的 H1V+ 患者年龄在 65 岁或以上，我们将从与棕榈泉艾森豪威尔医疗中心 (EMC) 的新合作中招募 4 名年龄较大（65 岁以上）的参与者。 CNTN 是国家神经艾滋病组织联盟 (NNTC) 的积极参与者，该联盟是由 NIH 资助的四个神经艾滋病组织库组成的合作伙伴。 CNTN 通过以下方式为 NNTC 做出贡献：1) 领导 NNTC 神经心理学和精神病学小组委员会并监督这些数据的质量保证，2) 指导历史抗逆转录病毒收集方法，3) 促进共同 NNTC 评估和神经病理学方案的完善，4 ) 审查并履行 NNTC 范围内的组织和样品请求，以及 5) 在 NNTC 指导委员会任职。 CNTN 将开展工作与 NNTC 密切合作，确保这一杰出的国家和国际神经艾滋病研究资源持续取得成功。