California NeuroAIDS Tissue Network

加州神经艾滋病组织网络

基本信息

批准号：
10797350
负责人：
CRISTIAN L ACHIM
金额：
$ 55.33万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-03-01 至 2024-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10797350
关键词：
Address Age Aging Antiviral Therapy Autopsy Biological Specimen Banks Biopsy Blood Brain California Central Nervous System Cerebrospinal Fluid Cessation of life Characteristics Chronic Clinical Clinical Data Clinical assessments Collaborations Collection Communities Data Data Coordinating Center Data Set Disease Enrollment Equipment and supply inventories Feces Functional disorder Funding Genetic Goals HIV HIV Infections HIV antiretroviral HIV therapy HIV-1 HIV-associated neurocognitive disorder HIV/AIDS Heart Highly Active Antiretroviral Therapy Individual International Kidney Laboratories Life Liquid substance Liver Longitudinal cohort Lung Lymphoid Tissue Maintenance Methods National NeuroAids Tissue Consortium Neurocognitive Neuropathogenesis Neuropsychology Nucleic Acids Participant Pathologic Peripheral Nervous System Persons Plasma Policies Procedures Protocols documentation Psychiatry Qualifying Quality Control Research Research Personnel Resources Sampling Site Skin Specimen Standardization Swab Technical Expertise Testis Tissue Banks Tissues United States National Institutes of Health Vascular Diseases Viral reservoir Voting abeta deposition age effect antiretroviral therapy clinical research site co-infection cofactor cohort comorbidity cost data de-identification data exchange design fecal microbiome follow-up interest lymph nodes member microbiome research neuroAIDS neuroimaging operation prospective quality assurance recruit repository research study response

项目摘要

ABSTRACT CNTN is an active participant in the National NeuroAIDS Tissue Consortium (NNTC), a partnership of four NIH-funded neuroAIDS tissue banks. The objectives of the CNTN remain the same today as it was when it was established in 1998 and encompass 1) recruitment, clinical assessment, and follow-up of a late-stage HIV cohort, and 2) collection, maintenance, and distribution of specimens to investigators interested in conducting research on the neuropathogenesis of HIV-induced central and peripheral nervous system dysfunction. This supplement is requested to cover the difference between CNTN’s minimal essential operations and operating in-full for the supplement period (03/01/2023 - 05/31/2023). Carryforward funds have been requested to cover minimal essential operations of the CNTN for this period, with many activities substantially diminished to reduce costs. CNTN will continue to maintain an in-life cohort of approximately 150 participants with the purpose of obtaining autopsies from high priority cases that are aligned with the thematic priorities of the RFA: a) HIV eradication from CNS reservoirs; b) mechanisms of HIV-associated neurocognitive disorders (HAND) in the setting of long-term HAART, and c) understanding comorbidities associated with HIV, including the effects of aging and chronic HIV-infection. CNTN will accumulate and manage a bank of in-life (plasma, CSF, blood) and autopsy (brain, heart, lung, liver, kidney, lymph node, blood, and CSF) specimens and data from persons living with HIV who are well characterized neuropsychologically, neuromedically, and psychiatrically. CNTN will collect tissues (e.g., gut lymphoid tissue, testes) for emerging CNS cure and eradication research. Unique within the NNTC, CNTN has assumed responsibility for CNS HIV-1 Antiretroviral Therapy Effects Research (CHARTER) specimens including plasma, CSF, buccal swabs, skin biopsies, and nucleic acids. De-identified CHARTER data (clinical, laboratory, genetic, neuroimaging, and research) have been transferred to the NNTC Data Coordinating Center (DCC), where they are now maintained. CNTN maintains both CNTN and CHARTER specimen resources. External requests for de-identified CNTN or CHARTER data or specimens are managed by the DCC in collaboration with NNTC sites, and the CNTN team is well equipped to provide timely distribution of both CNTN and CHARTER specimens according to NNTC data and resource distribution policies. Finally, CNTN continues to be an active collaborating member of the NNTC by: coordinating with the DCC and other NNTC sites; providing scientific and technical expertise to the wider research community as a voting member of the NNTC Steering Committee (SC), which reviews requests for data and specimens to facilitate neuroAIDS research; and as the leader of the NNTC Neuropsychology/Psychiatry subcommittee. Through the accomplishment of these objectives, the CNTN will continue to be a national and international resource serving the needs of neuroAIDS investigators.

抽象的 CNTN 是国家神经艾滋病组织联盟 (NNTC) 的积极参与者，该联盟由四个组织组成 NIH 资助的神经艾滋病组织库今天的目标与以前一样。成立于 1998 年，包括 1) 晚期 HIV 患者的招募、临床评估和随访队列，以及 2) 收集、维护样本并将其分发给有兴趣进行的研究人员 HIV引起的中枢和周围神经系统功能障碍的神经发病机制的研究。要求本补充内容涵盖 CNTN 的最低限度基本运营和已请求结转资金在补充期间（2023年1月3日至2023年5月31日）全面运营。覆盖这一时期 CNTN 的最低限度的基本业务，许多活动大幅减少为了降低成本，CNTN 将继续维持约 150 名参与者。从符合 RFA 优先主题的高优先级案件中获得尸检的目的： a) 从 CNS 储存库中根除 HIV；b) HIV 相关神经认知障碍 (HAND) 的机制长期 HAART 的设置，以及 c) 了解与 HIV 相关的合并症，包括其影响 CNTN 将积累和管理生命银行（血浆、脑脊液、血液）。尸体解剖（脑、心、肺、肝、肾、淋巴结、血液和脑脊液）标本和数据具有神经心理学、神经医学和精神病学特征的艾滋病毒感染者将会。收集组织（例如肠道淋巴组织、测试）用于新兴中枢神经系统治疗和根除研究。在 NNTC 内，CNTN 负责中枢神经系统 HIV-1 抗逆转录病毒治疗效果研究（宪章）样本，包括血浆、脑脊液、口腔拭子、皮肤活检和核酸。 CHARTER 数据（临床、实验室、遗传、神经影像和研究）已转移至 NNTC 数据协调中心 (DCC)，现在维护 CNTN 和 CNTN。 CHARTER 样本资源。对去识别化的 CNTN 或 CHARTER 数据或样本的外部请求。由 DCC 与 NNTC 站点合作管理，CNTN 团队装备精良，可以及时提供根据 NNTC 数据和资源分布，CNTN 和 CHARTER 标本的分布最后，CNTN 通过以下方式继续成为 NNTC 的积极合作成员： DCC 和其他 NNTC 站点；作为更广泛的研究界提供科学和技术专业知识； NNTC 指导委员会 (SC) 的投票成员，该委员会审查数据和样本的请求促进神经艾滋病研究；并担任 NNTC 神经心理学/精神病学小组委员会的领导者。通过实现这些目标，CNTN 将继续成为国内和国际满足神经艾滋病研究人员需求的资源。

项目成果

期刊论文数量（21）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Global NeuroAIDS roundtable.

DOI：
10.1007/s13365-012-0143-9
发表时间：
2013-02
期刊：
JOURNAL OF NEUROVIROLOGY
影响因子：
3.2
作者：
Joseph, Jeymohan;Achim, Cristian L.;Boivin, Michael J.;Brew, Bruce J.;Clifford, David B.;Colosi, Deborah A.;Ellis, Ronald J.;Heaton, Robert K.;Gallo-Diop, Amadou;Grant, Igor;Kanmogne, Georgette D.;Kumar, Mahendra;Letendre, Scott;Marcotte, Thomas D.;Nath, Avindra;Pardo, Carlos A.;Paul, Robert H.;Pulliam, Lynn;Robertson, Kevin;Royal, Walter, III;Sacktor, Ned;Sithinamsuwan, Pasiri;Smith, Davey M.;Valcour, Victor;Wigdahl, Brian;Wood, Charles
通讯作者：
Wood, Charles

PINCH in the cellular stress response to tau-hyperphosphorylation.

DOI：
10.1371/journal.pone.0058232
发表时间：
2013
期刊：
PloS one
影响因子：
3.7
作者：
Ozdemir AY;Rom I;Kovalevich J;Yen W;Adiga R;Dave RS;Langford D
通讯作者：
Langford D

The HIV Protein gp120 Alters Mitochondrial Dynamics in Neurons.

DOI：
10.1007/s12640-016-9608-6
发表时间：
2016-05
期刊：
Neurotoxicity research
影响因子：
3.7
作者：
Avdoshina V;Fields JA;Castellano P;Dedoni S;Palchik G;Trejo M;Adame A;Rockenstein E;Eugenin E;Masliah E;Mocchetti I
通讯作者：
Mocchetti I

Altered subcellular localization of the NeuN/Rbfox3 RNA splicing factor in HIV-associated neurocognitive disorders (HAND).

DOI：
10.1016/j.neulet.2013.10.037
发表时间：
2014-01-13
期刊：
Neuroscience letters
影响因子：
2.5
作者：
Lucas CH;Calvez M;Babu R;Brown A
通讯作者：
Brown A

Mechanisms of HIV-1 Tat neurotoxicity via CDK5 translocation and hyper-activation: role in HIV-associated neurocognitive disorders.

DOI：
10.2174/1570162x13666150311164201
发表时间：
2015
期刊：
Current HIV research
影响因子：
1
作者：
Fields JA;Dumaop W;Crews L;Adame A;Spencer B;Metcalf J;He J;Rockenstein E;Masliah E
通讯作者：
Masliah E