Imaging Core

成像核心

• 批准号: 8786120
• 负责人: ANDRE OBENAUS
• 金额: $ 19.47万
• 依托单位: LOMA LINDA UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8786120
• 关键词: Arteries; Astrocytes; Bayesian Modeling; Behavior; Behavioral; Biological Markers; Biological Neural Networks; Blood; Blood - brain barrier anatomy; Blood Vessels; Blood Volume; Brain; Brain Edema; Brain Injuries; Brain hemorrhage; Caveolins; Cellular biology; Cerebral hemisphere hemorrhage; Cerebrovascular Circulation; Cerebrum; Clinical; Common Data Element; Computer Analysis; Data; Data Set; Decision Making; Deposition; Development; Diffusion Magnetic Resonance Imaging; Disease; Edema; Endothelial Cells; Event; Funding Mechanisms; Gadolinium; Growth Factor; Growth Factor Receptors; Hemorrhage; Image; Injury; Ischemic Brain Injury; Lead; Location; Magnetic Resonance Imaging; Maps; Measures; Membrane; Methods; Modeling; Outcome; Pattern; Perfusion; Pericytes; Permeability; Physiological; Physiology; Predisposition; Receptor Signaling; Relative (related person); Research; Role; Rupture; Signal Pathway; Signal Transduction; Smooth Muscle Myocytes; Speed; Spin Labels; Statistical Models; Stroke; Subarachnoid Hemorrhage; T2 weighted imaging; Testing; Therapeutic; Therapeutic Intervention; Time; Traumatic Brain Injury; Weight; data mining; feeding; foot; gadolinium oxide; high throughput analysis; improved; indexing; injury and repair; insight; nervous system disorder; neuroimaging; neurovascular unit; novel; novel therapeutic intervention; white matter; white matter change

The Imaging Core supports the following Specific Aims ofthe three scientific projects ofthe Center for Brain Hemorrhage Research: 1) provide neuroimaging for edema (T2-weighted, T2W1), blood (T2WI and suscepribility weighted imaging, SWI), diffusion tensor imaging for white matter abnormalities, cerebral perfusion using both dynamic susceptibility contrast (DSC) and arterial spin labeling (ASL) approaches including cerebral blood volume (CBV), cerebral blood flow (CBF), mean transit time (MTT) and time to peak (TTP) indices; 2) undertake analysis for the collected imaging data, including anatomical mapping of edema and blood, blood brain barrier (BBB) disruption, white matter changes, cerebral perfusion abnormalities; 3) provide a centralized location for Project Pi's and staff to access raw and analyzed datasets; 4) develop and implement computational routines as we have for other disease states (i.e. stroke, TBI) to automate and speed analysis throughput, and 5) provide statistical and computational support for imaging data comparisons to behavior, cell biology and vascular outcomes. Our comprehensive approach will provide novel data about common interrelationships between three brain models of hemorrhagic injury, Subarachnoid Hemorrhage (SAH), Intracerebral Hemorrhage (ICH), and Traumatic Brain Injury (TBI). Clinical neuroimaging is increasingly taking a significant role in assessment of SAH, ICH, and TBI. A unifying feature of these neurological disease states is the deposition of extravascular blood which is extremely toxic to the brain and leads to rupture ofthe blood brain barrier (BBB). This cascade of events results in development of edema, often with catastrophic outcomes. Numerous studies have demonstrated that rapid imaging ofthe extent and anatomical location of blood is critical for decision-making relative to potential therapeutic interventions. Thus, the Imaging Core has elected for these Projects to focus on early and late indices of brain injury and function: 1) edema, 2) extravascular blood, 3) cerebral perfusion, and 4) white matter function. The Imaging Core will 1) undertake non-invasive but functional measures of brain physiology using MR imaging, 2) use standard and novel computational analysis to maximize data extraction, and 3) use numerical analysis methods to identify common data from all cores (Behavioral, Imaging, Vascular) that emerge for SAH, ICH, and TBI.

成像核心支持脑出血研究中心三个科学项目的以下具体目标：1）提供水肿神经成像（T2加权，T2W1）、血液（T2WI和磁敏感加权成像，SWI）、白质弥散张量成像异常，使用动态磁敏对比（DSC）和动脉自旋标记（ASL）方法的脑灌注，包括脑血容量（CBV）、脑血流量(CBF)、平均通过时间 (MTT) 和达峰时间 (TTP) 指数； 2）对采集的影像学数据进行分析，包括水肿和血液的解剖图、血脑屏障（BBB）破坏、白质变化、脑灌注异常等； 3) 为 Project Pi 和工作人员提供一个集中位置来访问原始数据集和分析后的数据集； 4) 开发和实施我们针对其他疾病状态（即中风、TBI）的计算例程，以实现自动化和加速分析吞吐量，5) 为成像数据与行为、细胞生物学和血管结果的比较提供统计和计算支持。我们的综合方法将提供关于出血性损伤、蛛网膜下腔出血（SAH）、脑内出血（ICH）和创伤性脑损伤（TBI）这三种脑模型之间常见相互关系的新数据。临床神经影像学在 SAH、ICH 和 TBI 的评估中发挥着越来越重要的作用。这些神经系统疾病状态的一个共同特征是血管外血液的沉积，这对大脑具有极大的毒性，并导致血脑屏障（BBB）破裂。这一系列事件导致水肿的发展，通常会带来灾难性的后果。大量研究表明，血液范围和解剖位置的快速成像对于与潜在治疗干预相关的决策至关重要。因此，影像核心选择这些项目重点关注脑损伤和功能的早期和晚期指标：1) 水肿，2) 血管外血液，3) 脑灌注，4) 白质功能。成像核心将 1) 使用 MR 成像对大脑生理学进行非侵入性但功能性的测量，2) 使用标准和新颖的计算分析来最大限度地提取数据，3) 使用数值分析方法来识别来自所有核心的通用数据（行为、针对SAH、ICH 和TBI 出现的影像学、血管学）。