Imaging Core

成像核心

• 批准号: 8661428
• 负责人: ANDRE OBENAUS
• 金额: $ 20.44万
• 依托单位: LOMA LINDA UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8661428
• 关键词: Arteries; Astrocytes; Bayesian Modeling; Behavior; Behavioral; Biological Markers; Biological Neural Networks; Blood; Blood - brain barrier anatomy; Blood Vessels; Blood Volume; Brain; Brain Edema; Brain Injuries; Brain hemorrhage; Caveolins; Cellular biology; Cerebral hemisphere hemorrhage; Cerebrovascular Circulation; Cerebrum; Clinical; Common Data Element; Computer Analysis; Data; Data Set; Decision Making; Deposition; Development; Diffusion Magnetic Resonance Imaging; Disease; Edema; Endothelial Cells; Event; Funding Mechanisms; Gadolinium; Growth Factor; Growth Factor Receptors; Hemorrhage; Image; Injury; Ischemic Brain Injury; Lead; Location; Magnetic Resonance Imaging; Maps; Measures; Membrane; Methods; Modeling; Outcome; Pattern; Perfusion; Pericytes; Permeability; Physiological; Physiology; Predisposition; Receptor Signaling; Relative (related person); Research; Role; Rupture; Signal Pathway; Signal Transduction; Smooth Muscle Myocytes; Speed; Spin Labels; Statistical Models; Stroke; Subarachnoid Hemorrhage; Testing; Therapeutic; Therapeutic Intervention; Time; Traumatic Brain Injury; Weight; data mining; feeding; foot; gadolinium oxide; high throughput analysis; improved; indexing; injury and repair; insight; nervous system disorder; neuroimaging; neurovascular unit; novel; novel therapeutic intervention; white matter; white matter change

The Imaging Core supports the following Specific Aims ofthe three scientific projects ofthe Center for Brain Hemorrhage Research: 1) provide neuroimaging for edema (T2-weighted, T2W1), blood (T2WI and suscepribility weighted imaging, SWI), diffusion tensor imaging for white matter abnormalities, cerebral perfusion using both dynamic susceptibility contrast (DSC) and arterial spin labeling (ASL) approaches including cerebral blood volume (CBV), cerebral blood flow (CBF), mean transit time (MTT) and time to peak (TTP) indices; 2) undertake analysis for the collected imaging data, including anatomical mapping of edema and blood, blood brain barrier (BBB) disruption, white matter changes, cerebral perfusion abnormalities; 3) provide a centralized location for Project Pi's and staff to access raw and analyzed datasets; 4) develop and implement computational routines as we have for other disease states (i.e. stroke, TBI) to automate and speed analysis throughput, and 5) provide statistical and computational support for imaging data comparisons to behavior, cell biology and vascular outcomes. Our comprehensive approach will provide novel data about common interrelationships between three brain models of hemorrhagic injury, Subarachnoid Hemorrhage (SAH), Intracerebral Hemorrhage (ICH), and Traumatic Brain Injury (TBI). Clinical neuroimaging is increasingly taking a significant role in assessment of SAH, ICH, and TBI. A unifying feature of these neurological disease states is the deposition of extravascular blood which is extremely toxic to the brain and leads to rupture ofthe blood brain barrier (BBB). This cascade of events results in development of edema, often with catastrophic outcomes. Numerous studies have demonstrated that rapid imaging ofthe extent and anatomical location of blood is critical for decision-making relative to potential therapeutic interventions. Thus, the Imaging Core has elected for these Projects to focus on early and late indices of brain injury and function: 1) edema, 2) extravascular blood, 3) cerebral perfusion, and 4) white matter function. The Imaging Core will 1) undertake non-invasive but functional measures of brain physiology using MR imaging, 2) use standard and novel computational analysis to maximize data extraction, and 3) use numerical analysis methods to identify common data from all cores (Behavioral, Imaging, Vascular) that emerge for SAH, ICH, and TBI.

成像核心支持大脑出血研究中心的三个科学项目的以下特定目标：1）为水肿提供神经影像学（T2加权，T2W1），血液（T2WI和可疑的加权成像，SWI，SWI），使用液质异常的繁殖力，散发性（swi）的繁殖均匀性，繁殖均匀的繁殖均匀性（繁殖量） （ASL）包括脑血容量（CBV），脑血流量（CBF），平均转运时间（MTT）和峰值（TTP）指数的方法； 2）对收集的成像数据进行分析，包括水肿和血液的解剖图，血液脑屏障（BBB）破坏，白质变化，脑灌注异常； 3）为PI项目和员工提供了一个集中位置，以访问原始和分析的数据集； 4）与其他疾病状态（即中风，TBI）相比，开发和实施计算例程以自动化和速度分析吞吐量，5）为对行为，细胞生物学和血管成果的成像比较提供统计和计算支持。我们的全面方法将提供有关三种出血性损伤，亚蛛网膜下腔出血（SAH），脑内出血（ICH）和创伤性脑损伤（TBI）的三种大脑模型之间常见相互关系的新数据。临床神经影像越来越多地在评估SAH，ICH和TBI中发挥了重要作用。这些神经系统疾病状态的统一特征是血管外血的沉积，对大脑具有极高的毒性，并导致血脑屏障破裂（BBB）。这串联的事件会导致水肿的发展，通常会带来灾难性的结果。大量研究表明，相对于潜在的治疗干预措施，血液的速度和解剖位置的快速成像对于决策至关重要。因此，成像核心已选出这些项目的重点是脑损伤和功能的早期和晚期指数：1）水肿，2）血管外血，3）脑灌注和4）白质功能。成像核心将1）使用MR成像，2）使用标准和新型的计算分析来最大程度地提取数据提取，以及3）使用数值分析方法来识别来自所有核心（行为，成像，血管，血管，ICH和TBI）。