Social and Genetic Contributions to Children's Sleep, Health, and Functioning

社会和遗传对儿童睡眠、健康和功能的贡献

• 批准号: 8818748
• 负责人: Leah Darrah Doane Sampey
• 金额: $ 61.95万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-05-15 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8818748
• 关键词: Accounting; Address; Affect; Age; Arizona; Behavior; Behavioral; Birth; Birth Records; Brain; Censuses; Child; Child Behavior; Child Development; Child Rearing; Childhood; Circadian Rhythms; Collaborations; Communities; Development; Environment; Environmental Risk Factor; Ethnic Origin; Etiology; Family; Future; Genes; Genetic; Genetic Determinism; Genetic Risk; Genetic study; Habits; Health; Health behavior; Heritability; Hispanics; Home environment; Hormonal; Hydrocortisone; Infant; Knowledge; Literature; Measures; Mediating; Methods; Minority Groups; Modeling; Outcome; Persons; Physical activity; Physiological; Population; Population Growth; Prevalence; Preventive Intervention; Price; Process; Recruitment Activity; Reporting; Research Personnel; Risk; Role; Sample Size; Sampling; Sleep; Sleep Disorders; Statistical Models; Stress; Systems Theory; Testing; Toddler; Twin Multiple Birth; Twin Studies; adverse outcome; base; behavioral health; cognitive performance; cohort; design; diaries; diet and exercise; early childhood; experience; genetic approach; indexing; infancy; physical conditioning; prenatal; public health relevance; resilience; social; stressor; trait

DESCRIPTION (provided by applicant): With our ethnically diverse longitudinal twin study, we aim to understand the genetic and environmental mechanisms by which the infant, toddler and childhood family sociocultural environments impact day-to-day associations between quality of sleep and health-related behaviors. Also, we elucidate mechanisms accounting for the longitudinal association between dynamic sleep processes and physical health and academic functioning in middle childhood. Without the use of a genetically-informed design, environmental causation cannot be inferred because quality of sleep is heritable, components of the family environment are also heritable through gene-environment correlation, and thus their covariation may be genetically or environmentally mediated. Salient aspects of the environment include a) family values and stressors (including culture-specific stressors), b) home stability and chaos and c) responsive and negative parenting. Specifically, under Aim 1 we model within person dynamic sleep and health behavioral processes in middle childhood, and the role of the sociocultural environment in moderating these processes. Under Aim 2, we predict physical health and academic functioning from children's average and dynamic sleep and health behavioral processes two years earlier. We also examine the extent to which these dynamic processes mediate the associations between the sociocultural environment and later physical health and academic functioning. With Aim 3, we use the twin method to document genetic and environmental contributions to multiple components of children's sleep, health and academic outcomes. Under Aim 4, we use the twin method to determine the extent to which the measured sociocultural environment moderates the heritability of sleep and health behaviors. This study would be the first to use a genetically-informative dynamic daily approach to understand sociocultural environment-sleep relations. The proposed study forms a new collaboration of a young team of investigators with complementary expertise. The project is notable for its developmental cultural and genetic approach that uncovers gene-environment interplay, extensive assessment of the sociocultural environment during a sensitive period for brain development, establishment of a circadian rhythm, and formation of bedtime routines and habits. Under a resilience framework, we study protective as well as risk processes, as protective environments such as sensitive parenting and bedtime routines likely offset genetic or environmental risk for sleep problems. Combining these design features exponentially increases the scientific contribution by elucidating processes that support preventive intervention efforts.

描述（由申请人提供）：通过我们的种族多样化的纵向双胞胎研究，我们旨在了解婴儿，幼儿和儿童家庭社会文化环境影响睡眠质量与健康相关行为之间的日常关联的遗传和环境机制。此外，我们阐明了动态睡眠过程与身体健康与学术功能之间纵向关联的机制。没有使用遗传信息的设计，就无法推断出环境因果关系，因为睡眠的质量是可遗传的，家庭环境的组成部分也可以通过基因 - 环境相关性而遗传，因此它们的协方差可能是遗传或环境介导的。环境的显着方面包括a）家庭价值观和压力源（包括特定于培养的压力源），b）家庭稳定性和混乱以及c）反应迅速且负面的育儿。具体而言，在AIM 1下，我们在童年中间的人动态睡眠和健康行为过程中建模，以及社会文化环境在调节这些过程中的作用。在AIM 2下，我们预测了两年前儿童平均睡眠和动态睡眠以及健康行为过程的身体健康和学术功能。我们还研究了这些动态过程在多大程度上介导社会文化环境与后来的身体健康和学术功能之间的关联。使用AIM 3，我们使用Twin方法记录了儿童睡眠，健康和学术成果的多种组成部分的遗传和环境贡献。在AIM 4下，我们使用双胞胎方法来确定测量的社会文化环境的程度减轻了睡眠和健康行为的遗传力。这项研究将是第一个使用遗传信息的动态日常方法来理解社会文化环境睡眠关系的人。拟议的研究构成了一个具有互补专业知识的年轻调查员团队的新合作。该项目以其发展性文化和遗传学方法而闻名，该方法在敏感的时期，建立昼夜节律的节奏以及就寝时间的常规和习惯的形成，揭示了对社会文化环境的基因 - 环境相互作用，广泛的评估。在弹性框架下，我们研究保护性和风险过程，作为敏感育儿和就寝时间常规等保护环境，可能会抵消睡眠问题的遗传或环境风险。通过阐明支持预防性干预工作的过程，将这些设计特征组合成指数级增加了科学贡献。