Social and Genetic Contributions to Children's Sleep, Health and Functioning

社会和遗传对儿童睡眠、健康和功能的贡献

• 批准号: 10534668
• 负责人: Leah Darrah Doane Sampey
• 金额: $ 62.19万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-05-15 至 2025-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10534668
• 关键词: Accounting; Acute; Address; Adolescence; Adolescent; Adolescent Development; Adult; Aerobic; Affect; Age; Anxiety; Arizona; Biological; Biological Markers; Birth Records; Characteristics; Child; Child Welfare; Childhood; Cognition; Collaborations; Communities; Complex; Data; Development; Developmental Process; Diagnosis; Disease; Emotional; Environment; Environmental Exposure; Environmental Risk Factor; Ethnic Origin; Exhibits; Genes; Genetic; Genetic Models; Genetic Risk; Genetic study; Goals; Growth; Health; Health Psychology; Heritability; Home; Hydrocortisone; Inflammation; Inflammatory; Intercept; Intervention; Knowledge; Link; Measurement; Measures; Mediating; Mental Depression; Mental Health; Modeling; Morbidity - disease rate; Muscle; Obesity; Outcome; Outcome Assessment; Pathway interactions; Pattern; Physiological; Physiological Processes; Physiology; Prevention; Process; Puberty; Reporting; Research; Risk; Risk Factors; Role; Sampling; Sleep; Sleep Disorders; Specific qualifier value; Specificity; Stress; Symptoms; Time; Twin Multiple Birth; Twin Studies; Weight; Work; Youth; conduct problem; design; experience; genetic approach; health disparity; inattention; infancy; mortality; novel; perceived stress; physical conditioning; poor sleep; preventive intervention; pubertal timing; public health relevance; recruit; resilience; sleep health; sleep quality; social; social culture; social media; socioeconomic disparity; socioeconomics; substance use

Project Summary With our ethnically and socioeconomically diverse longitudinal twin study, in this competing continuation we aim to understand the genetic and environmental mechanisms linking sleep and physical health across pubertal development. We also elucidate mechanisms accounting for longitudinal associations between these health processes and both mental health and inflammation in adolescence. Further, we examine a key proximal sociocultural process - daily media use - which is pervasive in the everyday lives of adolescents. With inflammation and mental health problems on the rise among youth, it is imperative that we utilize a well- powered (N=700 twin youth), representative (recruited from birth records), genetically-informed (twin study), longitudinal (followed since infancy with proposed assessments at 12 and 14 years) design to identify risk and resilience processes across the major transition from childhood to adolescence. To date, our results suggest that sleep is linked with cognition and health for genetic rather than environmental reasons (see C1), suggesting that third variables are involved that may vary by development (puberty). More specifically, we add two follow ups of a diverse twin sample recruited from birth records and assessed at 1, 2, 5, 8, 9, 10 & 11 years (N=700 youth; Arizona Twin Project). At 12 years, we add new assessments of the environment (e.g. media use) and extend our objective measures of sleep and health (aerobic, muscular, adiposity, physiology). At age 14, we add new outcome assessments (inflammatory biomarkers, mental health). Under Aim 1, we use parallel process growth models from childhood into adolescence to determine direction of effects among puberty, sleep, and multiple indicators of health. Under Aim 2, we dynamically extend this work by using intercepts and growth parameters from the parallel process growth models outlined in Aim 1 to predict inflammation and mental health at age 14. Under Aim 3, we examine the genetic and environmental overlap among puberty, sleep, and health and pinpoint aspects of the environment that play a role in health. Such an examination is critical as our work has shown that common risk factors and health are often associated for genetic as opposed to environmental reasons which can shift the focus of potential interventions. Under Aim 4, we disentangle genetic and environmental contributions to associations between daily sociocultural contexts, sleep and health. The proposed study builds on existing collaborations with complementary expertise. The project is notable as it is the only twin sample of youth to obtain longitudinal objective sleep, health, and sociocultural context data, for its developmental cultural and genetic approach that uncovers gene-environment interplay, measurement of physiological and inflammation biomarkers, and examination of proximal sociocultural processes including objective media use in adolescence. Combining these design features exponentially increases the scientific contribution, elucidating processes that support preventive intervention efforts.

项目摘要 通过我们的种族和社会经济多样化的纵向双胞胎研究，在这一竞争延续中，我们 旨在了解连接睡眠和身体健康的遗传和环境机制 青春期发展。我们还阐明了有关这些机制的纵向关联的机制 健康过程以及青春期的心理健康和炎症。此外，我们检查了一个钥匙 近端社会文化过程 - 日常媒体使用 - 在青少年的日常生活中普遍存在。和 炎症和心理健康问题正在增长，我们必须利用一个很好的 代表（从出生记录中招募）的动力（n = 700个双胞胎青年），遗传信息（双研究）， 纵向（紧随其后的是在12年和14年的拟议评估以来）设计，以确定风险和 从童年到青春期的重大过渡过程中的弹性过程。迄今为止，我们的结果表明 出于遗传而非环境原因，这种睡眠与认知和健康有关（请参阅C1）， 表明涉及的第三个变量可能因发育而有所不同（青春期）。更具体地说，我们补充 从出生记录中招募的多种双胞胎样本的随访，并在1、2、5、8、9、10和11进行评估 年（n = 700名青年；亚利桑那双胞胎项目）。在12年的时间里，我们添加了对环境的新评估（例如 媒体使用）并扩展我们对睡眠和健康的客观度量（有氧，肌肉，肥胖，生理学）。 在14岁时，我们添加了新的结果评估（炎症生物标志物，心理健康）。在AIM 1下，我们使用 从童年到青春期的平行过程增长模型，以确定影响方向 青春期，睡眠和健康指标。在AIM 2下，我们通过使用动态扩展这项工作 来自AIM 1中概述的并行过程增长模型的拦截和生长参数以预测 14岁时的炎症和心理健康。在AIM 3下，我们检查了遗传和环境重叠 在青春期，睡眠和健康和确定的环境方面，在健康中发挥了作用。这样的 检查至关重要，因为我们的工作表明，常见的风险因素和健康通常与 遗传而不是可以改变潜在干预措施重点的环境原因。在AIM 4下， 我们对每日社会文化背景之间的关联做出了遗传和环境贡献， 睡眠和健康。拟议的研究以互补的专业知识为基础。这 项目是值得注意的，因为它是唯一获得纵向客观睡眠，健康和 社会文化背景数据，因为它的发展文化和遗传方法揭示了基因环境 相互作用，测量生理和炎症生物标志物以及近端检查 社会文化过程，包括青春期的客观媒体使用。结合这些设计功能 指数增加了科学贡献，阐明了支持预防干预的过程 努力。