Conference on Physiological Bioenergetics: From Bench to Bedside

生理生物能量学会议：从实验室到临床

• 批准号: 8984379
• 负责人: Martin Frank
• 金额: $ 1.5万
• 依托单位: AMERICAN PHYSIOLOGICAL SOCIETY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8984379
• 关键词: Bioenergetics; Biology; Clinical Research; Collaborations; Discipline; Disease; Florida; Genomics; Goals; Health; Heart; Homeostasis; Human; Interdisciplinary Study; Knowledge; Link; Liver; Measurement; Metabolic; Mitochondria; Molecular; Oral; Organ; Organelles; Pathology; Physiological; Physiology; Postdoctoral Fellow; Research; Research Personnel; Role; Schedule; Tissues; Translating; Underrepresented Minority; base; bench to bedside; body system; graduate student; meetings; new technology; posters; programs; public health relevance; symposium; therapeutic development; therapeutic target; tool; translational study

 DESCRIPTION (provided by applicant): In the last 2-3 decades, it has become apparent that mitochondria perform a multitude of functions to maintain cellular homeostasis, all of which are intimately linked to both metabolic and genomic programs extending well beyond simply making ATP. New cutting edge technology, novel molecular tools and mitochondrially targeted therapeutics developed in the past 5-10 years have made it possible to more accurately and deeply probe mitochondrial function and have dramatically altered the study of bioenergetics under physiological conditions. Our knowledge of the mechanisms by which mitochondrial function is regulated and its contribution to cellular homeostasis is also rapidly expanding. However, these advances are generally made in the context of a specific pathology or organ system and are not always widely recognized by investigators studying a different pathology. Further, a great gap in knowledge still exists in translating mitochondrial measurement to human studies. The goal of the "Physiological Bioenergetics-from Bench to Bedside" meeting is to bring together experts studying varied facets of bioenergetics across disciplines and in the context of different pathologies to share their most recent findings and to discuss strategies to advance the field of "mitochondriology" into translational and clinical studies. The specific aims of the proposed conference are: 1. To bring together experts studying varied facets of bioenergetics across disciplines and in the context of different pathologies to share their most recent findings and to discuss strategies to advance the field of "mitochondriology" into translational and clinical studies. 2. To provide a venue for junior investigators, graduate students and post-doctoral fellows to highlight their research in the form of oral and poster presentations. 3. To catalyze collaboration/conversation across disciplines to understand the role of th mitochondrion in human health and disease. 4. To provide a forum in which underrepresented minorities can participate. The major appeal of this conference will be its focus on basic mitochondrial mechanisms that cross disciplines and specific pathologies. This meeting will serve as a cross disciplinary bridge, allowing the sharing of knowledge and the establishment of collaborations among investigators who may otherwise be confined within the discipline/pathology they study. Ultimately, the goals of this meeting are to advance the study of mitochondria, particularly in the realm of clinical studies and to catalyze collaboration/conversation across disciplines to understand the role of the mitochondrion in human health and disease.

 描述（由适用提供）：在过去的2-3年中，很明显，线粒体可以执行多种功能来维持细胞稳态，所有功能都与代谢和基因组方案均密切相关，而远远超出了ATP的范围。在过去的5 - 10年中开发的新型尖端技术，新型分子工具和线粒体靶向疗法已使得有可能更准确，更深入地探测线粒体功能，并在生理条件下大大改变了对生物能力的研究。我们对线粒体功能受到调节的机制的了解以及其对细胞稳态的贡献也正在迅速扩展。但是，这些进步通常是在特定的病理或器官系统的背景下进行的，并不总是通过研究不同病理学的研究人员广泛认可。此外，在将线粒体测量转化为人类研究中仍然存在很大的知识差距。 “从卧床基准到床边的生理生物能力”的目标是将研究各个学科生物能学方面的专家组合在一起，并在不同的病理学的背景下分享其最新发现，并讨论将“线粒体学”领域推进转化和临床研究的策略。 拟议会议的具体目的是： 1。汇集专家，研究各学科的生物能学方面的各个方面，并在不同的病理上分享他们的最新发现并讨论策略 将“线粒体学”的领域推向转化和临床研究。 2。为初级调查人员，研究生和博士后研究员提供场地，以口头和海报演示的形式强调他们的研究。 3。催化跨学科的协作/对话，以了解线粒体在人类健康和疾病中的作用。 4。提供一个论坛，在该论坛中，代表性不足的少数群体可以参加。 这次会议的主要外观将是它的重点是跨学科和特定病理的基本线粒体机制。这次会议将作为跨学科桥梁， 允许在调查人员之间共享知识和建立合作 被限制在他们研究的学科/病理中。最终，这次会议的目标是推进线粒体的研究，尤其是在临床研究领域，并催化跨学科的协作/对话，以了解线粒体在人类健康和疾病中的作用。