PLASTICITY OF LANGUAGE NETWORKS IN CHILDHOOD EPILEPSY

儿童癫痫中语言网络的可塑性

• 批准号: 8167328
• 负责人: WILLIAM Davis GAILLARD
• 金额: $ 0.24万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-20 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167328
• 关键词: Acute; Age; Biological Neural Networks; Brain region; Child; Childhood; Chronic; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Craniocerebral Trauma; Disease; Epilepsy; Functional Imaging; Funding; Goals; Grant; Institution; Knowledge; Language; Language Development; Location; Monitor; Neuronal Injury; Neurons; Partial Epilepsies; Patients; Process; Research; Research Personnel; Resources; Seizures; Source; Stroke; United States National Institutes of Health; critical period; imaging modality; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overarching goal of this study is to demonstrate that localization related epilepsy causes reorganization of language function in children during periods critical for language development. Knowledge of language systems development and plasticity in children will be gained to the extent that disruptions in normal neural networks for language function may be attributable to epilepsy. Unlike acute and limited neuronal insults, such as head trauma and stroke, epilepsy is a chronic process with continuing but paroxysmal neuronal injury. Furthermore, patients may be identified and evaluated at the outset of the disease process so that the neuronal responses and degree of plasticity may be assessed and monitored. A secondary goal is to use functional imaging methods to identify the brain regions that can sustain "reorganized" language function. The objectives of this study are to determine 1) whether children with chronic localization related epilepsy have different language organization than normal children; 2) whether children with new onset localization related epilepsy have different language organization than normal children; and 3) examine the association between extent and location of atypical language organization and age of seizure onset.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 这项研究的总体目标是证明与定位相关的癫痫会在语言发展的关键时期导致儿童语言功能的重组。将获得有关儿童语言系统发育和可塑性的知识，以了解语言功能正常神经网络的破坏可能归因于癫痫。与头部外伤和中风等急性和有限的神经元损伤不同，癫痫是一种慢性过程，伴有持续但阵发性的神经元损伤。此外，可以在疾病过程开始时识别和评估患者，以便可以评估和监测神经元反应和可塑性程度。第二个目标是使用功能成像方法来识别可以维持“重组”语言功能的大脑区域。 本研究的目的是确定：1​​）慢性定位相关性癫痫儿童的语言组织是否与正常儿童不同； 2）新发定位相关性癫痫儿童的语言组织是否与正常儿童不同； 3）检查非典型语言组织的范围和位置与癫痫发作年龄之间的关联。