Human and Animal Imaging Core

人类和动物成像核心

基本信息

批准号：
10686089
负责人：
WILLIAM Davis GAILLARD
金额：
$ 25.97万
依托单位：
CHILDREN'S RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-21 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10686089
关键词：
Affect Algorithms Anatomy Animal Model Animals Biochemical Bioinformatics Biological Markers Brain Brain Diseases Brain Injuries Brain imaging Cells Child Clinical Clinical Research Cognitive Collaborations Computer software Dedications Development Discipline Disease Disease model District of Columbia Dyslexia Education Epilepsy Evaluation Faculty Fostering Functional Imaging Genomics Hospitals Human Human Resources Image Imaging Device Imaging Techniques Imaging technology Inborn Errors of Metabolism Individual Infant Infrastructure Injury Inpatients Institution Intellectual and Developmental Disabilities Research Centers Intervention Investments Laboratories Learning Machine Learning Magnetic Resonance Imaging Measurement Methods Microscopy Mission Molecular Monitor Motion Neonatal Neuronal Plasticity Outcome Pathway Analysis Performance Play Population Positron-Emission Tomography Protocols documentation Quality Control Research Research Personnel Research Project Grants Resources Risk Role Services Site Spectrum Analysis Structure Supervision Targeted Research Technical Expertise Techniques Technology Time Tissues Training Universities Work analytical method animal imaging autism spectrum disorder career clinical translation congenital heart disorder cost cost effective data integrity data reduction data standards design fetal flexibility human imaging human model hypoxic ischemic injury imaging facilities imaging modality improved in vivo innovation instrument instrumentation molecular imaging neonate neural neural circuit neurobehavioral neuroimaging neuroprotection novel novel imaging technology perinatal stroke pre-clinical preclinical study response single photon emission computed tomography skills structural imaging

项目摘要

Abstract The Human and Animal Imaging Core (HAIC) provides access to state-of-the-art in vivo whole brain imaging technologies to DC-IDDRC investigators in order to support, facilitate, and enhance IDD-targeted research in humans and in animal models. To achieve the Core’s aims we have established advanced imaging facilities at three collaborating DC-IDDRC institutions - Howard University (HU), Georgetown University (GU), and Children’s National Hospital (CNH) - that provide structural and functional imaging of animal models and human populations. The HAIC provides access to a wide array of imaging tools to investigate mechanisms of disease, establish biomarkers, examine effects of disease, and monitor outcomes of interventions. We have made significant institutional investments in 3T human MRI scanners at CNH, and GU that provide researchers with state-of-the-art imaging instrumentation and expand our imaging capacity in neonates and ill children. Furthermore, we have also invested in MRI scanner/software upgrades and added PET, SPECT, and CT to the preclinical animal imaging facilities at HU. HAIC personnel provide technical expertise in imaging strategy design, essential imaging services, acquisition and innovative imaging sequences and analysis methods across all sites and institutions. Core faculty and staff also help educate, train, and support investigators in the use of advanced neuroimaging methods, applications, and analysis software as well as foster innovation. The HAIC works synergistically, and fosters collaborations, with other DC-IDDRC cores including the Neurobehavioral Evaluation, the Cell and Tissue Microscopy Core, the Genomics and Bioinformatics Core, and Clinical Translational Cores, and supports the P50 Research Project. Our administrative structure provides the quality control necessary for the integrity of a smoothly functioning core to achieve the DC-IDDRC mission.

抽象的人类和动物成像核心 (HAIC) 提供最先进的体内全脑成像向 DC-IDDDRC 研究人员提供技术，以支持、促进和加强针对 IDD 的研究为了实现核心目标，我们在人类和动物模型中建立了先进的成像设施。三个 DC-IDDDRC 合作机构 - 霍华德大学 (HU)、乔治城大学 (GU) 和国家儿童医院 (CNH) – 提供动物模型和动物模型的结构和功能成像 HAIC 提供了多种成像工具来研究人类群体的机制。疾病，建立生物标志物，检查疾病的影响，并监测干预措施的结果。在 CNH 和 GU 的 3T 人体 MRI 扫描仪上进行了大量机构投资，为研究人员提供配备最先进的成像仪器，并扩大我们对新生儿和患病儿童的成像能力。此外，我们还投资了 MRI 扫描仪/软件升级，并添加了 PET、SPECT 和 CT HU 的临床前动物成像设施提供成像策略方面的技术专业知识。设计、基本成像服务、采集和创新成像序列和分析方法所有站点和机构的核心教职人员还帮助教育、培训和支持研究人员。使用先进的神经影像方法、应用程序和分析软件并促进创新。 HAIC 与其他 DC-IDDRC 核心（包括神经行为评估、细胞和组织显微镜核心、基因组学和生物信息学核心，以及临床转化核心，并支持 P50 研究项目我们的管理结构提供了质量控制是实现 DC-IDDRC 使命所需的核心平稳运行的完整性所必需的。