Language and cognition after perinatal stroke

围产期卒中后的语言和认知

基本信息

批准号：
10527367
负责人：
WILLIAM Davis GAILLARD
金额：
$ 59.42万
依托单位：
GEORGETOWN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-12-01 至 2024-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10527367
关键词：
Adult Affect Age Area Automobile Driving Behavior Therapy Biological Birth Brain Brain Injuries Cerebral Palsy Child Cognition Cognitive Comprehension Data Development Emotions Environmental Risk Factor Exhibits Face Focal Brain Injuries Foundations Functional Magnetic Resonance Imaging Future Hemiplegia Human Impaired cognition Impairment Individual Infrastructure Injury Language Language Development Language Tests Left Life Linguistics Literature Longitudinal Studies Maps Methods Middle Cerebral Artery Infarction Modeling Names Neuropsychological Tests Outcome Patient Recruitments Pattern Performance Perinatal Perinatal Brain Injury Pharmacologic Substance Population Printing Process Production Property Recovery Research Research Personnel Schools Stroke System Techniques Teenagers Temporal Lobe Testing Variant Visual Work behavior test cognitive ability cognitive function cognitive testing developmental plasticity examination questions flexibility functional outcomes improved language impairment language outcome middle cerebral artery motor impairment neural neural patterning object recognition optimal treatments perinatal injury perinatal ischemic stroke perinatal stroke post stroke recruit skills stroke recovery young adult

项目摘要

PROJECT SUMMARY It has long been argued that the brain is most plastic during early development and that after brain injury, children reorganize cortical functions to healthy areas; but there is little understanding of these processes. Many investigators have shown that, when the left hemisphere (LH) is damaged, language can be subserved by the right hemisphere (RH). Here we ask how the linguistic functions of LH and RH are organized after LH injury and how well this atypical organization supports linguistic abilities. We also investigate the complementary questions regarding how these functions are organized after RH injury. We will study the long-term outcomes after ischemic perinatal stroke (IPS), due to its relatively clean properties for scientific analysis. IPS occurs in 1/4000 births and is the leading known cause of cerebral palsy. Many children with LH perinatal stroke develop near-normal language and cognitive abilities, but a substantial number show later language and cognitive impairments. Most literature shows that, after early LH stroke, language `reorganizes' to homotopic RH areas. Our pilot data suggest that, under these circumstances, typical LH and RH language functions divide up the RH cortical territory in new ways. We hypothesize that these functions develop best when different language functions find distinct RH localizations; overlap of linguistic functions will lead to more impaired performance. We will test this hypothesis by investigating language after LH perinatal injuries. We will also ask the same questions after RH perinatal injuries. We will recruit 30 teenagers and young adults who have had a LH perinatal stroke involving the middle cerebral artery and 30 who have had a similar RH perinatal stroke, compared with 30 healthy controls matched in age and SES. While IPS is rare, our research team is ideal for successful recruiting. We have developed our tasks and tested 16 children with perinatal strokes. We will administer a battery of behavioral and neuropsychological tests and 5 fMRI tasks. Two fMRI tasks (examining naming and sentence processing) test language functions that activate LH language areas in healthy controls. Two fMRI tasks (examining vocal emotion and intonation) test functions ordinarily controlled by the RH. Together these tasks examine how language abilities are affected when they develop in one hemisphere. An additional fMRI task examines specific object recognition (word recognition, ordinarily in LH VWFA, and face recognition, ordinarily in RH FFA) to ask if these functions are altered when their typical neural substrates are intact but language is shifted. Our behavioral tests assess how well all of these skills operate when neural organization is atypical. These studies will contribute to our understanding of the flexibility and limitations of early brain plasticity. In the future our findings can also help to provide a foundation for developing techniques to stimulate the most successful types of functional organization after early brain injuries.

项目概要长期以来，人们一直认为大脑在早期发育期间最具可塑性，而在脑损伤后，儿童将皮质功能重新组织到健康区域；但人们对这些过程了解甚少。许多研究人员表明，当左半球（LH）受损时，语言功能会受到损害由右半球（RH）。这里我们问LH和RH的语言功能在 LH 损伤以及这种非典型组织对语言能力的支持程度。我们还调查了关于 RH 损伤后这些功能如何组织的补充问题。我们将研究缺血性围产期卒中（IPS）后的长期结局，因为其相对干净用于科学分析的特性。 IPS 发生在 1/4000 的新生儿中，是已知的脑瘫的主要原因。许多患有 LH 围产期中风的儿童发展出接近正常的语言和认知能力，但数字显示后来的语言和认知障碍。大多数文献表明，早期 LH 卒中后，语言“重组”为同伦 RH 区域。我们的试点数据表明，在这种情况下，典型的左侧和右侧语言功能以新的方式划分右侧皮质区域。我们假设当不同的语言函数找到不同的 RH 本地化时，这些函数会得到最好的发展；的重叠语言功能会导致表现更加受损。我们将通过调查来检验这个假设 LH 围产期损伤后的语言。我们也会在 RH 围产期损伤后提出同样的问题。我们将招募 30 名患有 LH 围产期中风（涉及中段）的青少年和年轻人。脑动脉和 30 名患有类似 RH 围产期卒中的人，与 30 名健康对照者相比年龄和社会经济地位相匹配。虽然 IPS 很少见，但我们的研究团队是成功招聘的理想选择。我们有我们制定了任务并对 16 名患有围产期中风的儿童进行了测试。我们将管理一系列行为和神经心理学测试和 5 项功能磁共振成像任务。两项功能磁共振成像任务（检查命名和句子处理）测试激活健康对照组 LH 语言区域的语言功能。两项功能磁共振成像任务（检查声音情绪和语调）测试通常由 RH 控制的功能。这些任务一起检查如何当语言能力在一个半球发育时，就会受到影响。另一项功能磁共振成像任务检查特定对象识别（文字识别，通常在 LH VWFA 中，以及面部识别，通常在 RH 中） FFA）询问当它们的典型神经基质完好但语言发生变化时，这些功能是否会改变。我们的行为测试评估当神经组织不典型时所有这些技能的运作情况。这些研究将有助于我们理解早期大脑可塑性的灵活性和局限性。将来，我们的研究结果还可以帮助为开发刺激最大程度的技术奠定基础。早期脑损伤后成功的功能组织类型。

项目成果

期刊论文数量（11）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

The neural basis of language development: Changes in lateralization over age.

语言发展的神经基础：偏侧化随年龄的变化。

DOI：
发表时间：
2020-09-22
期刊：
影响因子：
11.1
作者：
Olulade, Olumide A;Seydell;Chambers, Catherine E;Turkeltaub, Peter E;Dromerick, Alexander W;Berl, Madison M;Gaillard, William D;Newport, Elissa L
通讯作者：
Newport, Elissa L

Developmental changes in neural lateralization for visual-spatial function: Evidence from a line-bisection task.

视觉空间功能神经侧化的发育变化：来自线平分任务的证据。

DOI：
发表时间：
2022-07
期刊：
影响因子：
3.7
作者：
Ferrara, Katrina;Seydell;Chambers, Catherine E;Newport, Elissa L;Landau, Barbara
通讯作者：
Landau, Barbara

Bilateral parietal activations for complex visual-spatial functions: Evidence from a visual-spatial construction task.

复杂视觉空间功能的双侧顶叶激活：来自视觉空间构建任务的证据。

DOI：
发表时间：
2017-11
期刊：
影响因子：
2.6
作者：
Seydell;Ferrara, Katrina;Chambers, Catherine E;Newport, Elissa L;Landau, Barbara
通讯作者：
Landau, Barbara

Revisiting Lenneberg's Hypotheses About Early Developmental Plasticity: Language Organization After Left-Hemisphere Perinatal Stroke.

重温伦伯格关于早期发育可塑性的假设：左半球围产期中风后的语言组织。

DOI：
发表时间：
2017
期刊：
影响因子：
0.6
作者：
Newport, Elissa L;Landau, Barbara;Seydell;Turkeltaub, Peter E;Chambers, Catherine E;Dromerick, Alexander W;Carpenter, Jessica;Berl, Madison M;Gaillard, William D
通讯作者：
Gaillard, William D

In Memoriam: Alexander W. Dromerick Jr, MD, July 1, 1958-August 21, 2021.

悼念：Alexander W. Dromerick Jr，医学博士，1958年7月1日至2021年8月21日。