Behavioral and inflammatory responses to stress: Implications for depression in youth exposed to adversity

对压力的行为和炎症反应：对处于逆境的青少年抑郁症的影响

基本信息

批准号：
9291816
负责人：
Kate Ryan Kuhlman
金额：
$ 17.24万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-08-01 至 2022-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9291816
关键词：
Acute Address Adolescent Affective Age Anxiety Behavior Behavioral Biological Biological Neural Networks Blood Childhood Cognitive Data Development Environmental Risk Factor Event Exposure to Health Incidence Individual Inflammation Inflammatory Inflammatory Response Intervention Laboratories Link Longevity Measurement Measures Mediating Mental Depression Mental Health Mental disorders Motivation Negative Valence Participant Pathway interactions Phase Phenotype Positive Valence Process Psychological Stress Psychopathology Recruitment Activity Recurrence Research Rewards Risk Risk Factors Saliva Sampling Signal Transduction Stress Substance abuse problem Suicide Suicide attempt Testing Treatment outcome United States Visit Youth acute stress behavior measurement behavioral response biobehavior child depression depressive symptoms experience follow-up inflammatory marker modifiable risk peer premature programs prospective psychologic psychological stressor relating to nervous system response treatment-resistant depression

项目摘要

Project Summary/Abstract Childhood adversity exposure is linked to recurrent and treatment resistant depression across the lifespan. Childhood adversity is also associated with exaggerated inflammatory responses to stress. Acute inflammatory responses can induce the behavioral phenotype for depression, including reduced motivation for rewards and enhanced sensitivity to threat. In this study, we aim to determine the association between childhood adversity and behavioral responses to acute psychological stress. We also aim to characterize the association between childhood adversity and inflammatory responses to stress. Finally, we aim to test whether the magnitude of inflammatory responses to acute stress mediate the behavioral response to threat. We hypothesize that youth exposed to childhood adversity will demonstrate greater increases in threat sensitivity, reward motivation, and markers of inflammation following acute psychological stress. Further, we hypothesize that inflammatory responses to stress will mediate changes in behavior in response to acute stress. We will recruit a sample of 90 adolescents (ages 12-15) exposed to high (4+ adverse childhood events) and low (0-3 adverse childhood events) adversity. During a laboratory visit, youth will complete several behavioral measures of reward motivation and threat sensitivity, participate in an acute psychological stress paradigm (TSST-C), and then complete measures of reward motivation and threat sensitivity 60 minutes after stress initiation. Throughout this laboratory assessment, we will collect blood and saliva to measure systemic, cellular, and intracellular markers of inflammation. We anticipate that data from this study will support our hypothesis that childhood adversity is associated with exaggerated behavioral and inflammatory responses to stress. Completion of this study will identify three modifiable risk factors (threat sensitivity, reward motivation, inflammation) for depression in at risk youth, and support a program of research examining cognitive and behavioral strategies that may mitigate these effects.

项目概要/摘要童年时期的逆境暴露与一生中复发性和难治性抑郁症有关。童年逆境也与对压力的过度炎症反应有关。急性炎症反应会诱发抑郁症的行为表型，包括奖励动机的减少和增强对威胁的敏感度。在这项研究中，我们的目的是确定童年逆境之间的关联以及对急性心理压力的行为反应。我们还旨在描述之间的关联童年逆境和对压力的炎症反应。最后，我们的目的是测试其大小是否对急性应激的炎症反应介导对威胁的行为反应。我们假设青年经历童年逆境会表现出威胁敏感性、奖励动机和急性心理压力后的炎症标志物。此外，我们假设炎症对压力的反应会介导针对急性压力的行为变化。我们将招募样本 90 名青少年（12-15 岁）暴露于高（4+ 次不良童年事件）和低（0-3 次不良童年事件）事件）逆境。在实验室参观期间，青少年将完成几项奖励行为措施动机和威胁敏感性，参与急性心理应激范式（TSST-C），然后压力开始后 60 分钟完成奖励动机和威胁敏感性的测量。自始至终在这次实验室评估中，我们将收集血液和唾液来测量全身、细胞和细胞内炎症标志物。我们预计这项研究的数据将支持我们的假设，即童年逆境与对压力的过度行为和炎症反应有关。完成此研究将确定三个可改变的风险因素（威胁敏感性、奖励动机、炎症）抑郁症高危青少年，并支持一项研究认知和行为策略的计划这可能会减轻这些影响。