An Affective Intervention to Reverse the Biological Residue of Low Childhood SES

扭转儿童社会经济地位低下生物残留的情感干预

• 批准号: 8929132
• 负责人: BARBARA LEE FREDRICKSON
• 金额: $ 11.59万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-30 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8929132
• 关键词: Accounting; Adult; Affect; Affective; Aging; American; Arthritis; Attention; Behavioral; Biological; C-reactive protein; Cardiac; Cardiovascular Diseases; Childhood; Chronic; Chronic Disease; Chronic stress; Communicable Diseases; Disadvantaged; Educational process of instructing; Effectiveness; Elderly; Emotional; Environment; Evidence based intervention; Experimental Designs; Future; Gene Expression; Genes; Goals; Health; Household; Immune system; Impulsivity; Individual; Inflammation; Inflammatory; Intervention; Learning; Length; Leukocytes; Life; Life Style; Love; Malignant Neoplasms; Mediator of activation protein; Meditation; Mental Depression; Mental Health; Metabolic; Molecular Profiling; Outcome; Participant; Pathway interactions; Placebo Control; Population; Positioning Attribute; Randomized; Randomized Controlled Trials; Recruitment Activity; Research; Risk; Risk Factors; Sampling; Socioeconomic Status; Testing; Time; Up-Regulation; Ursidae Family; Viral Antibodies; Work; base; biobehavior; blind; burden of illness; cardiovascular disorder risk; design; discounting; experience; gene repression; immune activation; improved; inclusion criteria; indexing; innovation; low socioeconomic status; meetings; middle age; mindfulness meditation; mortality; novel; physical conditioning; positive emotional state; psychologic; skills; socioeconomics; telomere; theories

 DESCRIPTION (provided by applicant): Individuals raised in low socioeconomic (SES) households have been found to bear 20%-40% increased risk of costly chronic and infectious diseases and all-cause mortality, even after accounting for adulthood SES. Illuminating the biological mechanisms of these health risks, recent research has determined that severe and chronic stress endured early in life can embed a decades-long "biological residue" within the immune system, as reflected in leukocyte basal gene expression profiles, leukocyte telomere length, and levels of chronic inflammation indexed by C-reactive protein. These biological risk factors are further exacerbated by behavioral proclivities, namely, impulsivity (indexed by delay discounting) and mistrust, which are also more probable among those reared in low SES households. The overarching goal of the proposed research is to investigate whether and how this identified biological residue can be reversed in midlife. An innovative upward spiral theory o lifestyle change positions warm and empathic emotional states as key pathways to unlocking the body's inherent plasticity to reverse entrenched biological risk factors. The PI's team has identified an affective intervention - the ancient practice of loving-kindness meditation (LKM) - that produces salubrious biological effects in healthy midlife adults. The innovation of the present study lies in testing this affective intervention in a sample of midlife adults on poor health trajectories by virtue of having low childhood SES plus present-day pathogenic behavioral tendencies (i.e., impulsivity and mistrust). A dual-blind placebo-controlled randomized controlled trial (RCT) is designed to provide proof of principle that early-established biological risks factors are mutable, not permanent. It targets three Specific Aims: (1) To test whether LKM, through its effects on positive emotions, can reverse the biological residue of low childhood SES as reflected in (a) leukocyte basal gene expression (up-regulation of pro-inflammatory genes and down-regulation of antiviral and antibody genes), (b) leukocyte telomere length, and (c) C-reactive protein; (2) to identify plausible behavioral and biological moderators of the hypothesized benefits of LKM in this at-risk sample, with candidate moderators being (a) time spent meditating and (b) metabolic profile; and (3) to identify plausible biological, behavioral, and psychological mediators of the hypothesized biological benefits of LKM-induced positive emotions in this at-risk sample, with candidate mediators being improvements in (a) cardiac vagal tone, (b) delay discounting, and (c) mistrust. This research stands to identify evidence-based interventions to drastically reduce the disease burden that disproportionately affects Americans raised in low SES households.

 描述（由适用提供）：发现在低社会经济（SES）家庭中养育的个人即使在成年人的SES后，也有20％-40％的慢性慢性和传染病风险增加了20％-40％。阐明这些健康风险的生物学机制，最近的研究确定，生命早期遭受的严重和慢性压力可以将长达数十年的“生物居住”嵌入到拟议的研究的总体目标中，以调查是否以及如何识别出来。中年可以逆转生物居住地。一种创新的向上螺旋理论o生活方式变化的位置温暖而善解人意的情绪状态是解锁人体继承可塑性以逆转生物学风险因素的关键途径。 PI的团队已经确定了一种情感干预 - 在健康的中年成年人中会产生善意的生物学效果。本研究的创新在于在中年成年人对健康轨迹的样本中测试这种情感干预措施，因为儿童期SES和当今的病原行为趋势（即冲动和不当信任）。双盲安慰剂对照随机对照试验（RCT）旨在提供原理证明，证明早期建立的生物学风险因素是可变的，而不是永久性的。它针对三个具体目的：（1）测试LKM是否通过对积极情绪的影响来扭转（a）白细胞基本基因表达（促炎性基因上调的上调），抗体和抗体基因的下调和抗体基因的下调，（b）Leukocyte telomete telomete cc-remere cc-reme cc-reme con（a），cot和抗体基因下调，反映了低儿童期生物学居住。 （2）在此高危样本中确定LKM假设益处的合理行为和生物学主持人，候选主持人是（a）时间花费冥想和（b）代谢概况； （3）在此高风险样本中，确定LKM诱导的积极情绪的假设生物学益处的合理生物学，行为和心理介体，候选人的候选者正在改善（a）心脏迷走神经调节，（a）延迟折现，以及（c）误解。这项研究旨在确定基于证据的干预措施，以大大减少对低SES家庭中饲养的美国人的不成比例的伯恩疾病。

项目成果

Attachment insecurity moderates emotion responses to mindfulness and loving-kindness meditation in adults raised in low socioeconomic status households.

• DOI: 10.1037/emo0001049
• 发表时间: 2022-09
• 期刊: EMOTION
• 影响因子: 4.2
• 作者: West, Taylor N;Don, Brian P;Fredrickson, Barbara L
• 通讯作者: Fredrickson, Barbara L

Effect of Mindfulness Versus Loving-kindness Training on Leukocyte Gene Expression in Midlife Adults Raised in Low-Socioeconomic Status Households.

• DOI: 10.1007/s12671-022-01857-z
• 发表时间: 2022-05
• 期刊: MINDFULNESS
• 影响因子: 3.6
• 作者: West, Taylor N;Zhou, Jieni;Brantley, Mary M;Kim, Sumi L;Brantley, Jeffrey;Salzberg, Sharon;Cole, Steve W;Fredrickson, Barbara L
• 通讯作者: Fredrickson, Barbara L