Steam Sterilizer for the McGavran-Greenberg Animal Facility at UNC Chapel Hill

北卡罗来纳大学教堂山分校麦加夫兰-格林伯格动物设施的蒸汽灭菌器

• 批准号: 8902300
• 负责人: Craig A Fletcher
• 金额: $ 50万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-01 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8902300
• 关键词: Air; Animal Experimentation; Animal Housing; Animal Model; Animals; Area; Biology; Biomedical Research; Carcinogens; Censuses; Collection; Communicable Diseases; Communities; Comprehensive Cancer Center; Decontamination; Direct Costs; Disease; Disease Outbreaks; Ecology; Ensure; Environmental Engineering technology; Extramural Activities; Faculty; Funding; Future; Genetic; Gnotobiotic; Grant; Housing; Immunology; Inbred Mouse; Infectious Diseases Research; Institutes; Laboratory Animal Production and Facilities; Longevity; Maintenance; Malignant Neoplasms; Microbiology; Mutant Strains Mice; North Carolina; Obesity; Pathology; Process; Public Health; Recombinants; Research; Research Personnel; Resources; Rodent; Safety; Schools; Site; Steam; System; United States National Institutes of Health; Universities; animal facility; exhaust; gastrointestinal; meetings; member; nanomedicine; nutrition; pathogen; prevent; programs

 DESCRIPTION (provided by applicant): The University of North Carolina at Chapel Hill (UNC-CH) has a well-funded biomedical research program, which includes a substantial number of investigators using rodent animal models. UNC-CH is also the site of several key rodent resources including one of four Mutant Mouse Regional Resource Centers (MMRRC), the National Gnotobiotic Rodent Resource Center (NGRRC), and the Collaborative Cross (CC) collection of recombinant inbred mice. These unique NIH sponsored resources serve the world-wide genetics and biomedical research community. These resources, combined with the expanding animal research programs at UNC-CH have contributed to the near doubling of the research animal census at UNC in the past seven years, with the increase consisting entirely of rodents. This proposal seeks to add a bulk steam sterilizer to the McGavran-Greenberg (McG) research animal facility as part of an institutional commitment to ensuring the safety and efficiency of the animal facilities across campus. The McG animal facility was originally constructed to house primarily large-animal species and now houses rodents for the UNC Gillings School of Global Public Health and faculty members from 13 different departments and centers including the following: Lineberger Comprehensive Cancer Center (LCCC), Center for Infectious Diseases, Center for Gastrointestinal Biology and Disease, Carolina Institute for Nanomedicine, Nutrition Obesity Research Center, and the Departments of Microbiology and Immunology, Environmental Sciences and Engineering, Nutrition, and Pathology. Funds from this renovation grant are crucial for: a) replacement of a 28-year- old autoclave that is necessary for maintenance of general housing and decontamination of caging to prevent rodent infectious disease outbreaks and b) for maintenance of an expanding infectious disease research program housed in the isolation cubicles area that is separate from the general animal housing area. We will attain our objective by pursuing the following three Specific Aims: 1. Replace the 28 year old cabinet style sterilizer with a large bulk steam sterilizer, providing pathogen free caging for an animal facility with an expanding research program within infectious disease, cancer, and other biomedical research initiatives; A 12222 Getinge bulk sterilizer will be purchased and installed to allow an increase in the number of barrier-housed animals to meet current research demands. 2. An underutilized biosafety level (BSL)-3 suite will be renovated to expand sterilizer capacity. Renovations in the physical configuration of the old biohazardous suite area will be made to support BSL-2 infectious disease studies and accommodate a bulk sterilizer for processing of cages from animals with experimental pathogens and carcinogens under conditions which meet compliance. 3. Replace one of the three air handler units (AHUs) that support the animal facility and the associated exhaust system. This 26 year old air handler is at the end of its functional lifespan and will be replaced with a new oversized unit to support additional future capacity and ease future renovations of the remaining AHUs. This project will support the successful research programs of 26 investigators with animals in McG that have extramural funding for a total of $18.9 million in annual direct cost funding, of which $183 million is NIH funding.

 描述（由申请人提供）：北卡罗来纳大学教堂山分校 (UNC-CH) 拥有资金充足的生物医学研究项目，其中包括大量使用啮齿动物模型的研究人员，并且 UNC-CH 也是多个研究中心的所在地。重要的啮齿动物资源包括四个突变小鼠区域资源中心 (MMRRC) 之一、国家知生啮齿动物资源中心 (NGRRC) 和重组近交小鼠的协作杂交 (CC) 收藏。这些由 NIH 资助的独特资源为全世界的遗传学和生物医学研究界提供服务。这些资源与 UNC-CH 不断扩大的动物研究项目相结合，使 UNC-CH 的研究动物普查数量在过去七年中几乎翻了一番。该提案旨在为 McGavran-Greenberg (McG) 研究动物设施增加一台大型蒸汽灭菌器，作为确保整个校园动物设施安全和效率的机构承诺的一部分。原本是主要用于饲养大型动物物种，现在为北卡罗来纳大学吉林斯全球公共卫生学院的啮齿类动物以及来自 13 个不同部门和中心的教职人员提供住宿，其中包括：莱恩伯格综合癌症中心 (LCCC)、传染病中心、胃肠道中心生物学与疾病学、卡罗莱纳纳米医学研究所、营养肥胖研究中心以及微生物学和免疫学、环境科学与工程、营养学和病理学系均由此获得资金。翻新补助金对于以下方面至关重要：a) 更换有必要的 28 年历史的高压灭菌器 b) 用于维护一般住房和净化笼舍，以防止啮齿动物传染病爆发；b) 用于维持在与一般动物饲养区域分开的隔离隔间区域内扩大的传染病研究计划。以下三个具体目标： 1. 取代28岁 带有大型散装蒸汽灭菌器的柜式灭菌器，为动物设施提供免费笼养的病原体，该动物设施在传染病、癌症和其他生物医学研究计划方面正在扩大研究项目，并将购买并安装一台 12222 Getinge 散装灭菌器； 允许增加屏障饲养动物的数量，以满足当前的研究需求。 2. 将翻新未充分利用的生物安全级别 (BSL)-3 套房，以扩大灭菌器容量。将对旧生物危害套房区域的物理配置进行翻新。为支持 BSL-2 传染病研究而设计，并容纳一个散装灭菌器，用于在符合要求的条件下处理带有实验病原体和致癌物的动物的笼子。 3. 更换三个空气之一。支持动物设施和相关排气系统的处理装置 (AHU) 这台已有 26 年历史的空气处理装置已达到其功能寿命，将更换为新的超大装置，以支持未来的额外容量并简化未来的改造。该项目将支持 McG 26 名研究人员的动物研究计划的成功，这些研究计划的外部资金总额为每年 1890 万美元的直接成本资金，其中 1.83 亿美元是 NIH 的资金。