UNC BSL3 Core Facility

北卡罗来纳大学 BSL3 核心设施

• 批准号: 10795381
• 负责人: Craig A Fletcher
• 金额: $ 791.68万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-06 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10795381
• 关键词: Animals; Communicable Diseases; Communities; Containment; Core Facility; Coronavirus; Disease Progression; Equipment; Future; Gills; Goals; Growth; Health; Human; Image; Immune response; Infection; Infectious Diseases Research; Infrastructure; Institution; Laboratories; Laboratory Research; Learning; Pathogenesis; Pharmacy Schools; Public Health; Readiness; Research; Research Personnel; Research Project Grants; Schools; Technology; biosafety level 3 facility; design and construction; future pandemic; health care availability; instrumentation; medical schools; microbial; novel therapeutics; novel vaccines; pathogenic virus; programs; recruit; response; square foot; usability

PROJECT SUMMARY / ABSTRACT: The central goal of this project is to construct a 10,000 square feet biosafety level 3 (BSL3) research laboratory core facility to promote readiness to respond to future pandemics. Infectious diseases pose a severe and increasing threat to human health, especially in communities that lack access to health care. UNC programs will soon exceed current infrastructure capacity due to increase demand. A strategic review of our microbial pathogenesis and infectious disease community concluded that urgent action was essential to support the high containment programs. Among the barriers to the growth of research was a lack of access to critical technologies and animal space within the existing BSL3 laboratories. This transformative BSL3 core facility will allow UNC to expand to meet current and projected research needs in the UNC School of Medicine, School of Pharmacy, and Gillings School of Global Public Health. UNC has engaged multiple stakeholders across the research community to design and construct a centralized BSL3 suite to characterize the immune responses to coronavirus and other emerging viral pathogens and learn about what drives immune response, disease progression, and protection against future infection. The proposal will attain four objectives: 1. Design and construct a high containment facility to bring investigators working on emerging and re-emerging infections together; 2. Enable access to specialized instrumentation including aerobiology and imaging equipment for supporting high containment research; 3. Create institution-wide core space to allow recruitment of new investigators to the infectious disease research community by increasing usable laboratory space in the BSL3 facility and purchasing new equipment that will serve investigators within the many UNC centers, institutes, and departments and their nationwide collaborators; 4. Enhance UNC's ability to lead the rapid response generating new therapeutics and vaccines to save lives on a local, national, and even global level.

项目摘要/摘要： 该项目的中心目标是建造一个10,000平方英尺的生物安全3级（BSL3）研究实验室 促进应对未来流行病的准备的核心设施。传染病造成严重且 对人类健康的威胁日益增加，特别是在缺乏医疗保健的社区。北卡罗来纳大学的项目将 由于需求增加，很快就会超过当前基础设施的容量。对我们微生物的战略审查 发病机制和传染病界得出的结论是，必须采取紧急行动来支持高 遏制计划。研究发展的障碍之一是缺乏关键技术 现有 BSL3 实验室内的动物空间。这一变革性的 BSL3 核心设施将使 UNC 能够 扩大以满足北卡罗来纳大学医学院、药学院当前和预计的研究需求 吉林斯全球公共卫生学院。北卡罗来纳大学与研究界的多个利益相关者进行了接触 设计和构建集中式 BSL3 套件来表征对冠状病毒和其他病毒的免疫反应 新兴病毒病原体并了解驱动免疫反应、疾病进展和保护的因素 预防未来的感染。该提案将实现四个目标： 1. 设计和建造高安全壳 将研究新出现和重新出现的感染的调查人员聚集在一起的设施； 2. 允许访问 用于支持高密闭性的专业仪器，包括空气生物学和成像设备 研究; 3. 创建全机构范围的核心空间，以招募新的传染病研究人员 研究社区通过增加 BSL3 设施中的可用实验室空间并购买新设备 将为北卡罗来纳大学许多中心、研究所和部门及其全国范围内的调查人员提供服务 合作者； 4. 增强北卡罗来纳大学领导快速反应、产生新疗法和疫苗的能力 在地方、国家、甚至全球层面拯救生命。