Cadiorenal and Metabolic Diseases Research Center

心肾和代谢疾病研究中心

• 批准号: 8432513
• 负责人: John E Hall
• 金额: $ 227.84万
• 依托单位: UNIVERSITY OF MISSISSIPPI MED CTR
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-05 至 2018-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8432513
• 关键词: Area; Basic Science; Biochemistry; Bioinformatics; Biomedical Research; Cardiology; Cardiovascular Diseases; Centers of Research Excellence; Cessation of life; Clinical; Clinical Research; Collaborations; Complex; Core Facility; Coronary Arteriosclerosis; Development; Diabetes Mellitus; Discipline; Disease; Education; Emerging Technologies; Endocrinology; Environment; Equipment; Faculty; Fostering; Funding; Genetic; Goals; High Prevalence; Housing; Hypertension; Image; Institution; Interdisciplinary Study; Investments; Kidney Diseases; Link; Medical Students; Medical center; Mentors; Metabolic Diseases; Minority; Mississippi; Molecular Biology; Molecular Genetics; Morbidity - disease rate; Nephrology; Neurosciences; Obesity; Pathology; Pharmacology; Physiology; Population; Population Research; Postdoctoral Fellow; Recruitment Activity; Renal function; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Risk Factors; Scientist; Services; Stroke; Systems Analysis; Training; Training Programs; Translational Research; Translations; Underrepresented Minority; United States; United States National Institutes of Health; Universities; Work; career development; graduate student; improved; in vivo; innovation; mortality; multidisciplinary; next generation; novel therapeutic intervention; pre-doctoral; prevent; programs; public health relevance; research and development; research facility

DESCRIPTION (provided by applicant): Cardiovascular, renal and metabolic diseases are inextricably linked and are the leading causes of mortality and morbidity in the United States, especially in Mississippi which has the highest prevalence in the nation of these diseases. These disorders usually cluster together and are highly interdependent. Obesity and associated metabolic disorders, such as diabetes, are major causes of cardiovascular and renal disease. Abnormal kidney function is an important cause as well as a consequence of hypertension, a key risk factor for cardiovascular diseases such coronary artery disease and stroke. Understanding the complex relationships among cardiovascular, renal, and metabolic disorders and developing new therapeutic approaches requires a paradigm shift in research that incorporates multidisciplinary integrated approaches, combining the efforts of basic, clinical and population scientists. A major objective of this proposal is to develop an internationally recognized Cardiorenal and Metabolic Diseases Research Center (CMDRC) that brings together a multidisciplinary group of basic, clinical and population scientists working on a common synergistic theme, and to facilitate their collaborations. The specific aims are: 1) To develop infrastructure and core facilities that foster excellence in basic, clinical, and population research in cardiorenal and metabolic diseases and increase competitiveness of junior investigators for independent funding from NIH and other national biomedical research programs.; 2) To develop mentoring and education programs and research support for promising junior investigators so that they can become productive, independent investigators who can successfully compete for NIH funding; 3) To achieve the specific aims of the research projects described by the junior investigators in this proposal, and to foster their career development; 4) To develop a pipeline of diverse predoctoral graduate students, medical students and postdoctoral fellows trained in cutting edge cardiorenal and metabolic diseases research so they become the next generation of researchers in this field; major emphasis will be placed on recruiting and mentoring underrepresented minority investigators through partnerships with local minority institutions; 5) To enhance collaborations and interactions among established investigators from multiple disciplines in cardiorenal and metabolic diseases at UMMC, as well as with external partners; 6) To strengthen cardiorenal and metabolic disease research at UMMC by recruiting new faculty with expertise in clinical and translational research and in emerging technologies, such as in vivo imaging, molecular genetics, bioinformatics, and systems analysis.

描述（由申请人提供）： 心血管、肾脏和代谢疾病之间有着千丝万缕的联系，是美国死亡率和发病率的主要原因，尤其是在密西西比州，该州这些疾病的患病率是全国最高的。这些疾病通常聚集在一起并且高度相互依赖。肥胖和相关代谢紊乱（例如糖尿病）是心血管和肾脏疾病的主要原因。肾功能异常是高血压的重要原因和后果，而高血压是冠状动脉疾病和中风等心血管疾病的关键危险因素。了解心血管、肾脏和代谢疾病之间的复杂关系并开发新的治疗方法需要研究范式的转变，纳入多学科综合方法，结合基础、临床和人口科学家的努力。该提案的一个主要目标是建立一个国际公认的心肾和代谢疾病研究中心（CMDRC），该中心汇集了由基础、临床和人口科学家组成的多学科小组，致力于共同的协同主题，并促进他们的合作。具体目标是： 1）发展基础设施和核心设施，促进 在心肾和代谢疾病的基础、临床和人群研究方面取得卓越成就，并提高初级研究人员获得 NIH 和其他国家生物医学研究项目独立资助的竞争力。 2) 为有前途的初级研究人员制定指导和教育计划以及研究支持，使他们能够成为富有成效的、独立的研究人员，并能够成功竞争 NIH 的资助； 3）实现本提案中初级研究者所描述的研究项目的具体目标，并促进他们的职业发展； 4) 培养一批接受尖端心肾和代谢疾病研究培训的多元化博士前研究生、医学生和博士后研究员，使他们成为该领域的下一代研究人员；将主要重视通过与当地少数群体机构的合作来招募和指导代表性不足的少数群体调查员； 5) 加强 UMMC 心肾和代谢疾病多个学科的现有研究人员之间以及与外部合作伙伴之间的合作和互动； 6) 通过招募具有临床和转化研究以及新兴技术（如体内成像、分子遗传学、生物信息学和系统分析）专业知识的新教师，加强 UMMC 的心肾和代谢疾病研究。