Cardiorenal and Metabolic Diseases Research Center

心肾与代谢疾病研究中心

• 批准号: 10630577
• 负责人: John E Hall
• 金额: $ 116.25万
• 依托单位: UNIVERSITY OF MISSISSIPPI MED CTR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-15 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10630577
• 关键词: Acceleration; Area; Basic Science; Biomedical Research; Book Chapters; Books; Cardiorenal syndrome; Cardiovascular Diseases; Centers of Research Excellence; Cessation of life; Clinical; Clinical Research; Collaborations; Complex; Core Facility; Coronary Arteriosclerosis; Dedications; Development; Diabetes Mellitus; Discipline; Disease; Education; Ensure; Equipment; Extramural Activities; Faculty; Fostering; Funding; Grant; Healthcare Systems; High Prevalence; Hypertension; Infrastructure; Institution; Interdisciplinary Study; International; Kidney Diseases; Laboratory Research; Link; Mentors; Metabolic Diseases; Mississippi; Morbidity - disease rate; Obesity; Paper; Phase; Pilot Projects; Population; Population Research; Postdoctoral Fellow; Productivity; Publishing; Renal function; Research; Research Infrastructure; Research Personnel; Resources; Scientist; Services; Stroke; Training; Training Programs; Translational Research; Translations; Underrepresented Minority; United States; United States National Institutes of Health; Work; cardiovascular risk factor; clinical center; disability; improved; innovation; kidney dysfunction; minority investigator; mortality; multidisciplinary; next generation; novel therapeutic intervention; prevent; programs; recruit; research and development; student training; success

OVERALL PROJECT SUMMARY/ABSTRACT Cardiovascular (CV), renal and metabolic diseases are inextricably linked and are the leading causes of mortality and morbidity in the U.S., especially in Mississippi which has the highest prevalence in the nation of these diseases. Cardiorenal and metabolic disorders usually cluster together and are highly interdependent. Obesity and associated metabolic disorders, such as diabetes mellitus, are major causes of CV and renal disease. Abnormal kidney function is an important cause as well as a consequence of hypertension, a key risk factor for CV diseases such as coronary artery disease and stroke. Understanding the complex relationships among CV, renal, and metabolic disorders and developing new therapeutic approaches requires a paradigm shift in research that incorporates multidisciplinary integrated approaches, combining the efforts of basic, clinical and population scientists. A major objective of this Phase 3 COBRE proposal is to amplify the success of Phases 1 and 2 in developing a leading Cardiorenal and Metabolic Diseases Research Center (CMDRC) that brings together a multidisciplinary group of basic, clinical and population scientists working on a common synergistic theme, and to facilitate their collaborations. The specific aims for Phase 3 are: 1) To further develop CMDRC infrastructure, a well-organized highly productive Pilot Projects Program (PPP), and sustainable research core facilities that foster excellence in basic, clinical, and population research in cardiorenal and metabolic diseases and increased competitiveness of CMDRC investigators for independent funding from NIH and other national biomedical research programs; 2) To enhance CMDRC mentoring and education programs that provide support for PPP investigators as well as other promising researchers so that they can become productive, independent investigators who are also effective collaborators on multidisciplinary research teams; 3) To amplify our pipeline of diverse postdoctoral fellows and students trained in cutting-edge cardiorenal and metabolic diseases research so they become the next generation of researchers in this field; major emphasis is placed on recruiting and mentoring underrepresented minority investigators through partnerships with local institutions and by leveraging training programs at UMMC; 4) To enhance collaborations and interactions among established and junior investigators from multiple disciplines in cardiorenal and metabolic diseases at UMMC, other IDeA supported programs, and external partners. These interactions will leverage resources provided by UMMC and other IDeA programs; 5) To further expand the number of highly productive, extramurally funded cardiorenal and metabolic disease researchers at UMMC by leveraging institutional resources to recruit additional new faculty with expertise in clinical and translational research, and in areas where there are gaps in CMDCR expertise. The CMDRC has been a major driver for marked expansion of cardiorenal and metabolic diseases research in Mississippi. Phase 3 support will amplify and ensure sustainability of our efforts to develop a highly productive CMDRC dedicated to improving lives through research, discovery, and innovation.

全面的 项目概要/摘要 心血管（CV）、肾脏和代谢疾病有着千丝万缕的联系，是导致死亡的主要原因 和美国的发病率，尤其是密西西比州，该州的患病率最高 疾病。心肾和代谢疾病通常聚集在一起并且高度相互依赖。肥胖 以及相关的代谢紊乱，例如糖尿病，是心血管疾病和肾脏疾病的主要原因。 肾功能异常是高血压的重要原因和后果，而高血压是高血压的关键危险因素 心血管疾病，例如冠状动脉疾病和中风。了解简历之间的复杂关系， 肾脏和代谢疾病以及开发新的治疗方法需要研究范式的转变 结合多学科综合方法，结合基础、临床和人群的努力 科学家。 COBRE 第 3 阶段提案的一个主要目标是扩大第 1 阶段和第 2 阶段的成功 建立领先的心肾和代谢疾病研究中心 (CMDRC)，汇集了 由基础、临床和人口科学家组成的多学科小组致力于共同的协同主题，以及 以促进他们的合作。第三阶段的具体目标是： 1) 进一步发展 CMDRC 基础设施， 组织良好、高效的试点项目计划 (PPP) 和可持续的研究核心设施 促进心肾和代谢疾病基础、临床和人群研究的卓越发展，并增加 CMDRC 研究人员获得 NIH 和其他国家生物医学独立资助的竞争力 研究计划； 2) 加强 CMDRC 为 PPP 提供支持的指导和教育计划 研究人员以及其他有前途的研究人员，以便他们能够变得富有成效、独立 研究人员也是多学科研究团队的有效合作者； 3）扩大我们的管道 接受过尖端心肾和代谢疾病研究培训的不同博士后研究员和学生 因此他们成为该领域的下一代研究人员；主要重点放在招聘和 通过与当地机构合作并利用影响力，指导代表性不足的少数族裔调查员 UMMC 的培训计划； 4) 加强老牌企业与初级企业之间的合作与互动 来自 UMMC 心肾和代谢疾病多个学科的研究人员以及其他 IDeA 支持 计划和外部合作伙伴。这些互动将利用 UMMC 和其他 IDeA 提供的资源 节目； 5) 进一步扩大高生产力、外部资助的心肾和代谢中心的数量 UMMC 的疾病研究人员利用机构资源招募更多新教师 临床和转化研究方面的专业知识，以及 CMDCR 专业知识存在差距的领域。这 CMDRC 一直是心肾和代谢疾病研究显着扩展的主要推动力 密西西比州。第三阶段的支持将扩大并确保我们开发高生产力的努力的可持续性 CMDRC 致力于通过研究、发现和创新来改善生活。