Center for Biomolecular Structure and Dynamics

生物分子结构与动力学中心

• 批准号: 8915217
• 负责人: Stephen R Sprang
• 金额: $ 193.67万
• 依托单位: UNIVERSITY OF MONTANA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8915217
• 关键词: Address; Adenylate Cyclase; Arenavirus; Binding Sites; Biochemical; Biochemistry; Biological; Biological Sciences; Biology; Biophysics; Catabolism; Catalysis; Cells; Centers of Research Excellence; Chemicals; Chemistry; Collaborations; Core Facility; Dioxygenases; Enzymes; Esapent; Faculty; Floor; Foundations; Funding; Glycoproteins; Goals; Homology Modeling; Human; Infection; Interdisciplinary Study; Investigation; Junin virus; Ligand Binding; Ligands; Magnetism; Mediating; Membrane Fusion; Membrane Proteins; Mental disorders; Mentors; Mentorship; Methods; Molecular; Molecular Computations; Molecular Machines; Molecular Structure; Montana; Multi-Drug Resistance; Nuclear; Opioid Receptor; Perception; Pharmacologic Substance; Physiology; Plant Roots; Positioning Attribute; Property; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Science; Self Assessment; Signal Transduction; Spectrum Analysis; Structure; System; Tertiary Protein Structure; Theoretical Biology; Tryptophan; Universities; Viral; Viral Proteins; Vision; X ray diffraction analysis; X-Ray Crystallography; X-Ray Diffraction; amino acid metabolism; base; chemical genetics; computational chemistry; design; empowered; enzyme mechanism; human disease; indoleamine; infrastructure development; innovation; interest; member; molecular dynamics; multidisciplinary; programs; protein complex; quantum chemistry; research facility; research study; structural biology

The Center for Biomolecular Structure and Dynamics (CBSD) at the University of Montana (UM) is rooted in structural biology but multidisciplinary in scope. The rationale that underlies this program is based on the perception that effective biomedical innovation is driven from an understanding of macromolecular structure, which in turn, must be grounded on principles of experimental and theoretical chemistry. CBSD faculty are drawn from Department of Chemistry & Biochemistry, the Division of Biological Science and the Department of Biomedical and Pharmaceutical Sciences. Among this group are CBSD faculty with expertise in spectroscopy, structural biology, biochemistry and mechanistic and theoretical chemistry. We build on a strong foundation of sustained institutional support. Associated with the CBSD is a newly established interdisciplinary graduate program in Biochemistry and Biophysics. The goal of the proposed COBRE is to integrate investigators with research interests in cell and molecular physiology, mechanistic biochemistry, chemical biology, and theoretical and computational chemistry, into an interactive and collaborative network. With the creation of a CBSD COBRE, it is our goal to give structure to this vision by implementing the four aims of this proposal: Aim 1. Provide research support for five interdisciplinary research projects within the COBRE theme. These projects use theoretical and physical chemical methods to elucidate the catalytic mechanisms of enzymes involved in signal transduction and tryptophan catabolism. Structure-based homology modeling and chemical biology approaches will be used to design new ligands for the opioid receptor and to characterize the binding sites of the multidrug resistance transporter. Heteronuclear NMR experiments will be used to elucidate the structures of critical domains in the Junin arenavirus membrane fusion glycoprotein. Aim 2 shall be to recruit two new faculty members to CBSD-affiliated departments to build on existing strengths and introduce new expertise within the CBSD. Aim 3 will support collaborative activities involving CBSD faculty by sustaining of critical core research facilities in Macromolecular X-ray diffraction, Macromolecular NMR, BioSpectroscopy and Molecular Computation. Aim 4 will establish a supportive program to sustain an intellectually vibrant and cohesive CBSD that promotes infrastructure development, mentoring, scientific exchange and collaboration, with a robust advisory and self-assessment structure.

蒙大拿大学（UM）的生物分子结构与动力学中心（CBSD）植根于结构生物学，但在范围内多学科。该计划基于的基本原理是基于对有效的生物医学创新的看法，这是从对大分子结构的理解中驱动的，而大分子结构又必须基于实验和理论化学原理。 CBSD教职员工来自化学与生物化学系，生物科学系和生物医学和制药科学系。该小组中有CBSD教师，具有光谱，结构生物学，生物化学和机械和理论化学方面的专业知识。我们基于持续的机构支持的强大基础。与CBSD相关的是一项新成立的生物化学和生物物理学跨学科研究生计划。所提出的杂种的目的是将研究人员与细胞和分子生理学，机械生物化学，化学生物学以及理论和计算化学的研究兴趣相结合，并将其纳入交互式和协作网络。通过创建CBSD Cobre，我们的目标是通过实施该提案的四个目标来赋予该愿景结构： AIM 1。为COBRE主题中的五个跨学科研究项目提供研究支持。这些项目使用理论和物理化学方法来阐明参与信号转导和色氨酸分解代谢的酶的催化机制。基于结构的同源性建模和化学生物学方法将用于设计用于阿片类药物受体的新配体，并表征多药剂抗性转运蛋白的结合位点。异核NMR实验将用于阐明Junin Arenavirus膜融合糖蛋白中关键结构域的结构。 AIM 2应是将两名新教师招募到CBSD附属部门，以基于现有优势，并在CBSD中引入新的专业知识。 AIM 3将通过维持大分子X射线衍射，大分子NMR，生物光谱和分子计算中关键的核心研究设施来支持涉及CBSD教师的协作活动。 AIM 4将建立一项支持计划，以维持具有强大的咨询和自我评估结构的基础设施开发，指导，科学交流和协作，以促进基础设施开发，指导，科学交流和协作。