Center for Biomolecular Structure and Dynamics

生物分子结构与动力学中心

基本信息

批准号：
8530256
负责人：
Stephen R Sprang
金额：
$ 197.34万
依托单位：
UNIVERSITY OF MONTANA
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-09-01 至 2016-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8530256
关键词：
Address Adenylate Cyclase Amino Acids Arenavirus Binding Sites Biochemical Biochemistry Biological Biological Sciences Biology Biophysics Catabolism Catalysis Cells Centers of Research Excellence Chemicals Chemistry Collaborations Core Facility Dioxygenases Enzymes Esapent Faculty Floor Foundations Funding Glycoproteins Goals Homology Modeling Human Infection Interdisciplinary Study Investigation Junin virus Ligand Binding Ligands Magnetism Mediating Membrane Fusion Membrane Proteins Mental disorders Mentors Mentorship Metabolism Methods Molecular Molecular Computations Molecular Machines Molecular Structure Montana Multi-Drug Resistance Nuclear Opioid Receptor Perception Pharmacologic Substance Physiology Plant Roots Positioning Attribute Property Recruitment Activity Research Research Infrastructure Research Personnel Research Project Grants Research Support Science Self Assessment Signal Transduction Spectrum Analysis Structure System Tertiary Protein Structure Theoretical Biology Tryptophan Universities Viral Viral Proteins Vision X ray diffraction analysis X-Ray Crystallography X-Ray Diffraction base chemical genetics computational chemistry design empowered enzyme mechanism human disease indoleamine infrastructure development innovation interest kappa opioid receptors member molecular dynamics multidisciplinary programs protein complex quantum chemistry research facility research study structural biology

项目摘要

The Center for Biomolecular Structure and Dynamics (CBSD) at the University of Montana (UM) is rooted in structural biology but multidisciplinary in scope. The rationale that underlies this program is based on the perception that effective biomedical innovation is driven from an understanding of macromolecular structure, which in turn, must be grounded on principles of experimental and theoretical chemistry. CBSD faculty are drawn from Department of Chemistry & Biochemistry, the Division of Biological Science and the Department of Biomedical and Pharmaceutical Sciences. Among this group are CBSD faculty with expertise in spectroscopy, structural biology, biochemistry and mechanistic and theoretical chemistry. We build on a strong foundation of sustained institutional support. Associated with the CBSD is a newly established interdisciplinary graduate program in Biochemistry and Biophysics. The goal of the proposed COBRE is to integrate investigators with research interests in cell and molecular physiology, mechanistic biochemistry, chemical biology, and theoretical and computational chemistry, into an interactive and collaborative network. With the creation of a CBSD COBRE, it is our goal to give structure to this vision by implementing the four aims of this proposal: Aim 1. Provide research support for five interdisciplinary research projects within the COBRE theme. These projects use theoretical and physical chemical methods to elucidate the catalytic mechanisms of enzymes involved in signal transduction and tryptophan catabolism. Structure-based homology modeling and chemical biology approaches will be used to design new ligands for the opioid receptor and to characterize the binding sites of the multidrug resistance transporter. Heteronuclear NMR experiments will be used to elucidate the structures of critical domains in the Junin arenavirus membrane fusion glycoprotein. Aim 2 shall be to recruit two new faculty members to CBSD-affiliated departments to build on existing strengths and introduce new expertise within the CBSD. Aim 3 will support collaborative activities involving CBSD faculty by sustaining of critical core research facilities in Macromolecular X-ray diffraction, Macromolecular NMR, BioSpectroscopy and Molecular Computation. Aim 4 will establish a supportive program to sustain an intellectually vibrant and cohesive CBSD that promotes infrastructure development, mentoring, scientific exchange and collaboration, with a robust advisory and self-assessment structure.

蒙大拿大学 (UM) 生物分子结构与动力学中心 (CBSD) 植根于结构生物学，但范围涵盖多个学科。该计划的基本原理是基于这样一种认识，即有效的生物医学创新是由对大分子结构的理解驱动的，而大分子结构又必须以实验和理论化学原理为基础。 CBSD的教师来自化学与生物化学系、生物科学系以及生物医学与药物科学系。该团队中包括具有光谱学、结构生物学、生物化学以及机械和理论化学专业知识的 CBSD 教师。我们建立在持续的机构支持的坚实基础上。与 CBSD 相关的是一个新设立的生物化学和生物物理学跨学科研究生项目。拟议的 COBRE 的目标是将细胞和分子生理学、机械生物化学、化学生物学以及理论和计算化学方面的研究兴趣整合到一个交互式和协作网络中。随着 CBSD COBRE 的创建，我们的目标是通过实现该提案的四个目标来构建这一愿景：目标 1. 为 COBRE 主题内的五个跨学科研究项目提供研究支持。这些项目利用理论和物理化学方法来阐明参与信号转导和色氨酸分解代谢的酶的催化机制。基于结构的同源建模和化学生物学方法将用于设计阿片受体的新配体并表征多药耐药转运蛋白的结合位点。异核核磁共振实验将用于阐明胡宁沙粒病毒膜融合糖蛋白的关键结构域的结构。目标 2 是为 CBSD 附属部门招聘两名新教员，以发挥现有优势并在 CBSD 内引入新的专业知识。目标 3 将通过维持高分子 X 射线衍射、高分子核磁共振、生物光谱和分子计算方面的关键核心研究设施，支持 CBSD 教师参与的合作活动。目标 4 将建立一个支持性计划，以维持充满活力和凝聚力的 CBSD，通过强大的咨询和自我评估结构促进基础设施开发、指导、科学交流和合作。