2013 Fibronectin, Integrins & Related Molecules GRC/GRS

2013 纤连蛋白、整合素

• 批准号: 8458354
• 负责人: VALERIE MARIE WEAVER
• 金额: $ 0.12万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-02-06 至 2014-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8458354
• 关键词: Address; Adhesions; Atherosclerosis; Basic Science; Biological; Blood Platelets; California; Cardiovascular Diseases; Cardiovascular system; Cell Adhesion; Cell Adhesion Process; Cell Differentiation process; Cell Maintenance; Cell Nucleus; Cell-Cell Adhesion; Cell-Matrix Junction; Cells; Cellular Morphology; Clinical Treatment; Collaborations; Complex; Cytoskeleton; Development; Disease; Education; Embryonic Development; Engineering; Extracellular Matrix; Fibronectins; Government; Growth; Health; Homeostasis; Host Defense; Individual; Infection; Inflammatory; Integrins; International; Knowledge; Lead; Leukocyte Trafficking; Life; Link; Malignant Neoplasms; Mechanics; Mediating; Methods; Microscopy; Molecular; Morphogenesis; Myocardial Infarction; Neoplasm Metastasis; Organism; Participant; Physiologic Neovascularization; Postdoctoral Fellow; Property; Reperfusion Injury; Research; Research Personnel; Resistance; Role; Scheme; Scientist; Senior Scientist; Signal Transduction; Site; Solid Neoplasm; Stem cells; Stroke; Structure; Systems Development; Therapeutic; Thrombosis; Thrombus; Tissues; Training; Training and Education; Translating; Treatment Efficacy; Tumor Angiogenesis; United States National Institutes of Health; Vascular blood supply; Vascular remodeling; Wound Healing; abstracting; adhesion receptor; cancer therapy; cell behavior; cell motility; cohort; data exchange; experience; graduate student; human disease; improved; malignant phenotype; mathematical model; meetings; member; migration; neoplastic cell; next generation; novel therapeutic intervention; posters; programs; public health relevance; receptor; symposium; tumor

DESCRIPTION (provided by applicant): We request partial support for the Fibronectin, Integrins and Related Molecules Gordon Research Conference (GRC) and Gordon Research Seminar (GRS). The meetings will be held February 10-15, and February 9-10, 2013 in the Ventura Beach Marriott, Ventura, California, respectively. The broad and long-term objectives of the conference are firstly to increase our understanding of: 1) how interactions between cells and the surrounding extracellular matrices contribute to normal development and homeostasis; 2) how to use this knowledge to obtain a greater understanding and treatment of human diseases, such as cancer and cardiovascular disease; 3) the fundamental molecular mechanisms of cell matrix adhesion, involving complex supramolecular structures extending from the extracellular matrix outside the cell, through transmembrane receptors such as intregrins, to the cytoskeleton and nucleus; 4) how the molecules of the integrin adhesome are especially adapted to respond to and transduce mechanical force. Our second objective is to contribute to the education and training the next generation of scientists. The addition and renewal of the GRS that precedes the GRC provides an exceptional opportunity for graduate students, post- docs, and other scientists with comparable levels of experience and education to discuss their current research with each other and 4 more senior scientists. From past experience it is evident that this scheme strengthens the confidence of the attendees so that they are more active and engaged in the main GRC. The specific aims of this application are to hold a GRS and a GRC that advance the field. The two day GRS will convene 2 invited speakers, 2 discussion leaders with up to 50 graduate student and postdoctoral attendees, 12 of whom will be selected to give talks. The five day GRC that follows will convene 22 invited speakers, with 150 attendees, including the GRS participants, 22 of which will be selected for talks. Both programs will contain poster sessions to further maximize scientific discussions. These meetings seek to advance the field by addressing two challenges shared by many biological fields at present. The first is to integrate robust quantitative analysis, biophysical ad engineering approaches, advanced microscopy and mathematical modeling to enhance our understanding of molecular mechanisms. In particular, it is vital that we bring these approaches to elucidate the special mechano-sensing properties of the integrin adhesion machinery. The second is to use methods to address function within the intact organism, leading the way to a better understanding of how these molecules contribute to development, homeostasis and disease, so that treatments of integrin and ECM related diseases can be improved. We especially seek to understand how mechanical properties of the extracellular matrix and the links to the cytoskeleton have such profound effects on cell behavior.

描述（由申请人提供）：我们请求对纤连蛋白、整合素和相关分子戈登研究会议（GRC）和戈登研究研讨会（GRS）提供部分支持。会议将于2013年2月10日至15日和2013年2月9日至10日分别在加利福尼亚州文图拉的文图拉海滩万豪酒店举行。会议的广泛和长期目标首先是增加我们对以下方面的理解：1）细胞与周围细胞外基质之间的相互作用如何促进正常发育和体内平衡； 2）如何利用这些知识来更好地了解和治疗人类疾病，例如癌症和心血管疾病； 3）细胞基质粘附的基本分子机制，涉及从细胞外基质延伸到细胞外的复杂超分子结构，通过整合素等跨膜受体，到达细胞骨架和细胞核； 4）整合素粘附体的分子如何特别适应于响应和转换机械力。我们的第二个目标是为下一代科学家的教育和培训做出贡献。在 GRC 之前添加和更新 GRS 为研究生、博士后和其他具有相当经验和教育水平的科学家提供了一个绝佳的机会，让他们可以彼此以及另外 4 名资深科学家讨论他们当前的研究。从以往的经验来看，该计划显然增强了与会者的信心，使他们更加积极地参与主要的GRC。该申请的具体目标是举办 GRS 和 GRC 来推动该领域的发展。为期两天的 GRS 将召集 2 名受邀演讲者、2 名讨论主持人，最多 50 名研究生和博士后参加者，其中 12 名将被选中进行演讲。接下来为期五天的 GRC 将召集 22 名受邀演讲者，共有 150 名与会者，其中包括 GRS 参与者，其中 22 人将被选中进行演讲。这两个项目都将包含海报会议，以进一步最大化科学讨论。这些会议旨在通过解决目前许多生物领域面临的两个挑战来推动该领域的发展。第一个是整合强大的定量分析、生物物理广告工程方法、先进的显微镜和数学模型，以增强我们对分子机制的理解。特别是，我们利用这些方法来阐明整合素粘附机制的特殊机械传感特性至关重要。第二个是使用方法来解决完整有机体内的功能，从而更好地了解这些分子如何促进发育、稳态和疾病，从而改善整合素和 ECM 相关疾病的治疗。我们特别寻求了解细胞外基质的机械特性以及与细胞骨架的联系如何对细胞行为产生如此深远的影响。