Pacific Northwest Center for Translational Environmental Health Research

西北太平洋转化环境健康研究中心

• 批准号: 10602516
• 负责人: Jamie DeWitt
• 金额: $ 120.43万
• 依托单位: OREGON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10602516
• 关键词: Access to Information; Address; Air; Anatomy; Animal Experiments; Area; Behavioral; Big Data; Biological; Biological Assay; Biomedical Research; Categories; Cell Culture Techniques; Chemical Exposure; Chemicals; Collaborations; Commerce; Communities; Core Facility; Country; Data; Data Science; Devices; Diet; Disease; Drug Costs; Drug Targeting; Environmental Health; Event; Exhibits; Exposure to; Flame Retardants; Gene Expression; Goals; Hazardous Chemicals; Health; Health Personnel; Health Sciences; Home; Human; Human Biology; Individual; Industry; Institution; Interdisciplinary Study; International; Knowledge; Laboratories; Learning; Mammals; Manufacturer; Measurable; Methods; Modeling; Motor Activity; National Institute of Environmental Health Sciences; Nature; Noise; Nonprofit Organizations; Oregon; Organ; Organism; Outcome; Pacific Northwest; Pathway interactions; Persons; Pesticides; Pharmacologic Substance; Phenotype; Physiology; Poison; Population; Positioning Attribute; Predisposition; Public Health; Reproducibility; Research; Research Personnel; Research Project Grants; Robot; Running; Safety; Sampling; Science; Scientist; Services; Signal Transduction; Soil; Specific qualifier value; Strategic Planning; Structure; Techniques; Technology; Toxic Environmental Substances; Toxic effect; Toxicology; Toxin; Translational Research; Translations; Universities; Volatilization; Water; Workplace; Zebrafish; adverse outcome; biological research; community engagement; cost; data to knowledge; decision research; drug development; drug discovery; evidence base; experience; experimental study; germ free condition; good laboratory practice; hazard; health literacy; human tissue; improved; insight; interest; member; microbiome; multidisciplinary; phthalates; remediation; response; skills; success; tool; transcriptomics; volatile organic compound; whole genome

OVERALL SUMMARY A dominant paradigm of environmental health science is the adverse outcome pathway. The adverse outcome pathway contains an external segment and an internal segment. The external segment is a toxic chemical that comes into contact with a person. That chemical may come from air, water, soil, or diet. The internal segment of the outcome pathway consists of a chain of events: the chemical interacts with a biological target, which triggers events that in turn lead to organ responses, organism responses, and population responses. This framework supports the most important environmental health science questions of our era: What chemical exposures cause disease? How do they cause disease? Why are some people more susceptible than others? How can we predict toxicity? How can we mitigate the impacts of hazardous chemicals? How can we reduce the use of toxic chemicals in commerce? To answer these questions, the OSU EHS CC has an established world-leading position in two of the world's most powerful technologies for investigating the adverse outcome pathway. To study the external segment, the Chemical Exposure (CXC) Facility Core has developed passive sampling wristbands that capture volatile and semi-volatile organic chemicals, as well as analytical techniques that can detect and quantify 1,500 compounds in a single run at low cost. To study the internal segment, the Zebrafish Biomedical Research (ZBR) Facility Core has built the world's largest specific-pathogen-free (i.e., low- experimental-noise) zebrafish environmental health sciences facility. Robots evaluate locomotor activity and look for physical and behavioral endpoints. Full-genome transcriptomics analyses reveal which gene expressions change before the phenotype changes. Together, the CXC and the ZBR give our investigators uniquely powerful experimental capabilities in EHS. Furthermore, these technologies are more than complementary; they are synergistic. We have applied wristband extracts as direct input to the zebrafish bioassay and identified the most toxic compounds in chemical mixtures via effects-directed analysis. Our Integrated Health Sciences Facilities and Community Engagement Cores will make these capabilities available to the extended EHS community via a new translational research model. We plan to co-produce knowledge with stakeholders in seven categories (residential communities, legislators, regulators, manufacturers, health care providers, pharmaceutical firms, and non-profit organizations). EHS CC members will conduct cross- sectoral multidisciplinary research with these stakeholders in order to generate actionable scientific evidence to guide stakeholder decisions that will improve environmental public health.

总结 环境健康科学的主要范式是不利的结果途径。不利结果 途径包含外部段和一个内部段。外部细分市场是一种有毒化学物质 与一个人接触。该化学物质可能来自空气，水，土壤或饮食。内部细分市场 结果途径的一系列事件组成：该化学物质与生物靶标相互作用，该靶标相互作用 触发事件反过来导致器官反应，有机体反应和人群反应。这 框架支持我们时代最重要的环境健康科学问题：什么化学 暴露会导致疾病？它们如何引起疾病？为什么有些人比其他人更容易受到影响？如何 我们可以预测毒性吗？我们如何减轻危险化学物质的影响？我们如何减少使用 商业中有毒化学物质？为了回答这些问题，OSU EHS CC具有既定的世界领先地位 在世界两种最强大的技术中，用于调查不良结果途径的位置。到 研究外部细分市场，化学暴露（CXC）设施核心已开发了被动采样 捕获挥发性和半挥发性有机化学物质的腕带以及可以的分析技术 以低成本的方式检测并量化1,500种化合物。为了研究内部细分市场，斑马鱼 生物医学研究（ZBR）设施核心已经建立了世界上最大的特定Pathogenth（即低 - 斑马鱼环境健康科学设施。机器人评估运动活动和 寻找物理和行为终点。全基因组转录组学分析揭示了哪种基因 表型变化之前的表达式发生变化。 CXC和ZBR一起为我们的调查人员提供了 EHS中具有独特功能的实验功能。此外，这些技术不仅仅是 补充;它们是协同作用的。我们已将腕带提取物作为直接输入到斑马鱼 生物测定并通过效应指导的分析确定化学混合物中最具毒性的化合物。我们的 综合健康科学设施和社区参与核心将使这些功能可用 通过新的翻译研究模型来到扩展的EHS社区。我们计划共同生产知识 利益相关者分为七个类别（居民社区，立法者，监管机构，制造商，卫生 护理提供者，制药公司和非营利组织）。 EHS CC成员将进行交叉 与这些利益相关者的部门多学科研究 指导利益相关者的决定将改善环境公共卫生。