Biomarker Epidemiology of In Utero Environmental Exposures and Child Development

子宫内环境暴露和儿童发育的生物标志物流行病学

• 批准号: 8989332
• 负责人: John D. Meeker
• 金额: $ 16.52万
• 依托单位: NORTHEASTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8989332
• 关键词: 4 year old; Address; Air Pollution; Asthma; Behavior; Behavioral; Biological; Biological Markers; Chemical Exposure; Chemicals; Child; Child Development; Child health care; Clinical; Cohort Studies; Communities; Community Outreach; Data; Data Aggregation; Data Set; Databases; Development; Diet; Endocrine disruption; Environmental Exposure; Environmental Pollution; Epidemiology; Exposure to; Fetal Development; Fetal Growth; Funding; Future; Goals; Growth; Health; Human; Hypersensitivity; Incidence; Individual; Infant; Inflammation; Intervention; Island; Life; Link; Measures; Mediating; Mediation; Metals; Modification; Obesity; Outcome Study; Oxidative Stress; Parabens; Parents; Pathway interactions; Perinatal Exposure; Phenols; Policies; Population; Predisposition; Pregnancy; Pregnancy Outcome; Pregnant Women; Premature Birth; Public Health; Puerto Rico; Research; Respiratory physiology; Risk Assessment; Sampling; Services; Socioeconomic Status; Statistical Models; Testing; Time; Toxic effect; Translations; United States National Institutes of Health; Woman; cohort; design; developmental disease; early childhood; early life exposure; effective intervention; environmental chemical; epidemiology study; feeding; fetal; human subject; in utero; innovation; maternal stress; neurodevelopment; novel; parent project; phthalates; pollutant; prenatal exposure; reproductive; reproductive development; screening; social; trend; urinary

PROJECT SUMMARY Incidence rates for a range of adverse child developmental conditions have increased in recent years in the US and elsewhere. There is emerging evidence and concern that exposure to environmental chemicals such as phenols, parabens, and others may contribute to this recent rise in developmental disorders. Additionally, disparities exist in both incidence rates of adverse health conditions and level of pollutant exposure. There are particularly high rates of a number of developmental conditions, as well as elevated exposures to phenols and parabens, in Puerto Rico. Environmental phenols and parabens disrupt endocrine function, induce oxidative stress, and cause other alterations that may result in reduced fetal or child growth, preterm birth, reproductive tract anomalies, neurodevelopmental delays, obesity, allergies/asthma, and other effects. While near- ubiquitous exposures to these chemicals have been documented among pregnant women, well-designed human studies are greatly needed to determine whether developmental impacts are related to early life in utero exposure. In addition, few studies have addressed the real life situation of considering multiple exposures and susceptibility factors individually and together. Our preliminary data show that pregnant women in Puerto Rico may have higher exposures to several of these chemicals than women in the US and elsewhere, significant associations between these chemicals and markers of hypothesized mechanistic pathways, and that certain modifiable behaviors, such as use of specific products during pregnancy, are associated with elevated chemical exposure and suggest effective intervention strategies may be possible. The proposed project is designed to fill these research gaps by leveraging an ongoing NIH-funded pregnancy cohort study in Puerto Rico (P42ES017198) that is building a rich dataset on environmental, clinical, social, demographic, behavioral, dietary and other factors among 1800 pregnant women. The proposed study will follow 600 children born into the cohort through the age of 4 years. Our specific aims are to 1) Investigate the association between prenatal exposure to environmental phenols and parabens, estimated via urinary biomarkers at multiple times during pregnancy, and pregnancy outcomes and child development (including preterm birth, measures of infant feeding, child growth, reproductive development, neurodevelopment, and lung function); 2) Provide evidence for biological mechanisms that may mediate the relationship between early life exposure to environmental phenols or parabens and fetal/child development, including endocrine disruption, inflammation, and oxidative stress; 3) Test effect modification of the relationship between phenols or parabens and fetal/child development by a range of susceptibility factors, including socioeconomic status, maternal stress, and preterm birth; and 4) develop and apply innovative statistical approaches to explore fetal/child development effects of early-life exposure to multi-pollutant mixtures when also incorporating air pollution data that will be collected in Project 1 of this Center, and biomarker data on phthalates and metals being measured as part of the parent study.

项目概要 近年来，美国一系列不良儿童发育状况的发病率有所上升 和其他地方。越来越多的证据和担忧表明，暴露于环境化学物质，例如 苯酚、对羟基苯甲酸酯和其他物质可能导致最近发育障碍的增加。此外， 不良健康状况的发生率和污染物暴露水平都存在差异。有 许多发育状况的发生率特别高，以及苯酚和酚类物质的暴露量增加 对羟基苯甲酸酯，在波多黎各。环境酚类和对羟基苯甲酸酯会扰乱内分泌功能，诱发氧化 压力，并引起其他变化，可能导致胎儿或儿童生长减缓、早产、生殖能力下降 气道异常、神经发育迟缓、肥胖、过敏/哮喘和其他影响。虽然近- 据记录，孕妇普遍接触这些化学物质，经过精心设计 非常需要人类研究来确定发育影响是否与子宫内的早期生命有关 接触。此外，很少有研究涉及考虑多重暴露和 单独和共同的易感因素。我们的初步数据显示，波多黎各的孕妇 与美国和其他地方的女性相比，这些化学物质的接触量可能更高，这很重要 这些化学物质与假设的机械途径标记物之间的关联，以及某些 可改变的行为，例如在怀孕期间使用特定产品，与升高有关 化学暴露并提出有效的干预策略是可能的。拟议项目是 旨在通过利用 NIH 资助的波多黎各妊娠队列研究来填补这些研究空白 Rico (P42ES017198) 正在构建一个关于环境、临床、社会、人口统计、行为、 1800 名孕妇的饮食和其他因素。拟议的研究将跟踪 600 名出生于 该队列的年龄为 4 岁。我们的具体目标是 1) 调查产前妊娠之间的关联 暴露于环境酚和对羟基苯甲酸酯，通过尿液生物标志物多次评估 怀孕、妊娠结局和儿童发育（包括早产、婴儿的测量 喂养、儿童生长、生殖发育、神经发育和肺功能）； 2）提供证据 寻找可能介导生命早期暴露于环境之间关系的生物机制 酚类或对羟基苯甲酸酯与胎儿/儿童发育，包括内分泌干扰、炎症和氧化 压力; 3) 酚类或对羟基苯甲酸酯与胎儿/儿童发育关系的试验效果修正 受一系列易感因素影响，包括社会经济地位、产妇压力和早产；和 4) 开发并应用创新的统计方法来探索早期生命对胎儿/儿童发育的影响 暴露于多种污染物混合物，同时还纳入项目 1 中收集的空气污染数据 该中心的数据，以及作为母研究的一部分正在测量的邻苯二甲酸盐和金属的生物标志物数据。