DREAM: Discovering cancer Risks from Environmental contaminants And Maternal/child health

梦想：发现环境污染物和母婴健康带来的癌症风险

• 批准号: 10491264
• 负责人: Peggy Reynolds
• 金额: $ 111.18万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-20 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10491264
• 关键词: 4 year old; Address; Air; Area; Aromatic Amines; Biological Assay; Biological Markers; Biological Monitoring; Blood; California; Cancer Etiology; Cancer-Related Condition; Carcinogens; Characteristics; Chemicals; Child; Chronic; Clinical; Collaborations; Collection; Common Data Element; Communities; DNA Damage; Data; Data Collection; Development; Early identification; Endocrine Disruptors; Enrollment; Environment; Environmental Carcinogens; Environmental Exposure; Environmental Health; Environmental Pollutants; Environmental Pollution; Environmental Risk Factor; Exposure to; Feedback; Funding; Future; Geographic Information Systems; Geography; Hair; Health; Hormonal; Hormones; Hospitals; Immune response; Incidence; Infant; Inflammation; Infrastructure; Interdisciplinary Study; Knowledge; Laboratories; Life; Link; Longterm Follow-up; Malignant Childhood Neoplasm; Malignant Neoplasms; Maternal and Child Health; Measures; Mediating; Medical; Methods; Modification; Morphology; Mothers; Nail plate; Neighborhoods; Outcome; Oxidative Stress; Participant; Patient Recruitments; Pesticides; Phase; Phenols; Physiological; Plasticizers; Poly-fluoroalkyl substances; Population Heterogeneity; Positioning Attribute; Predisposition; Pregnancy; Pregnant Women; Prevention; Process; Questionnaires; Recording of previous events; Records; Research; Research Priority; Risk; Risk Factors; Role; Saliva; Sampling; San Francisco; Science; Second Pregnancy Trimester; Site; Surveys; System; Testing; Translations; Urine; Water; Woman; Work; base; cancer diagnosis; cancer epidemiology; cancer risk; cell immortalization; cohort; community engagement; consumer product; data management; design; environment related cancer; environmental chemical; environmental chemical exposure; epidemiology study; ethnic diversity; experience; flexibility; immunoregulation; information system analysis; innovation; insight; malignant breast neoplasm; mammary; neoplasm registry; offspring; phthalates; pollutant; population based; population health; prenatal exposure; programs; racial diversity; receptor; recruit; reproductive epidemiology; research and development; research data dissemination

Project Summary/Abstract The UCSF Discovering cancer Risks from Environmental contaminants And Maternal/child health (DREAM) cohort will enhance our understanding of how multiple exposures to environmental chemicals and pollutants across a diverse population of pregnant women and their offspring are linked to cancer risks. We will enroll and follow an economically, geographically, ethnically, and racially diverse participant pool of pregnant women and their children in the San Francisco Bay Area and California’s Central Valley. Because pregnancy induces multiple maternal hormonal and physiological changes that can increase cancer susceptibility to environmental chemical exposures, we will focus on pregnancy as a period of particular vulnerability to toxic agents. We will collect questionnaire data and biospecimen samples starting at the second trimester of pregnancy up until the child reaches four years of age. We will also establish a Cohort Ambassador Program to invite participants across our three sites to provide continuous feedback which we will integrate into our research priorities. Our specific aims are designed to address the hypothesis that exposures to environmental chemicals that disrupt endocrine and other systems during this important life phase predispose women and children to cancer, as identified via intermediate cancer risk biomarkers. Our environmental exposures will focus on two major components: Consumer product related chemicals (including per- and polyfluoroalkyl substances [PFAS], phthalates and plasticizers, phenolic compounds, pesticides, and aromatic amines) measured via biomonitoring and prioritized based on widespread public exposure; and environmental pollutants in air and water, evaluated via geographic information system analyses of participants’ residential histories. Our outcomes will focus on biomarkers of risk for future cancer incidence including: short-term outcomes focusing on associations with key characteristics that are intermediate cancer risk biomarkers (immune response and chronic inflammation, oxidative stress and DNA damage, hormone disruption/receptor mediated effects, and cell immortalization). For longer term outcomes we will link cohort participants to California’s statewide population-based cancer registry, hospital discharge data, vital records, and Medi-Cal files in later years of the project to identify diagnoses of cancer and related conditions. Our multidisciplinary collaboration is built on our extensive knowledge and experience conducting large-scale research on environmental exposures during pregnancy and environmental risk factors for cancer. Our proposed cohort development and research plan will advance our understanding of multiple pollutant exposures in a young geographically and demographically diverse cohort, thus substantially advancing our knowledge on enhanced susceptibility to carcinogens linked to specific outcomes during these critical and understudied periods, combined with a platform that will allow flexibility and future collaboration to enhance our study as new science emerges.

项目概要/摘要 加州大学旧金山分校发现环境污染物和母婴健康带来的癌症风险 （DREAM）队列将增强我们对多次暴露于环境化学品和 不同人群的孕妇及其后代的污染物与癌症风险有关。 注册并关注经济、地理、民族和种族多样化的孕妇参与者群体 旧金山湾区和加利福尼亚州中央山谷的妇女及其孩子因为怀孕。 诱导多种母体荷尔蒙和生理变化，从而增加癌症易感性 环境化学物质暴露，我们将重点关注怀孕期间，因为它是特别容易受到有毒物质影响的时期 我们将从妊娠中期开始收集问卷数据和生物样本。 怀孕直至孩子四岁 我们还将设立一个队列大使计划 邀请我们三个站点的参与者提供持续的反馈，我们将把这些反馈纳入我们的研究中 我们的具体目标旨在解决暴露于环境化学品的假设。 在这个重要的生命阶段扰乱内分泌和其他系统使妇女和儿童容易 通过中等癌症风险生物标志物确定的癌症，我们的环境暴露将集中在两个方面。 主要成分：消费品相关化学品（包括全氟烷基物质和多氟烷基物质 [PFAS]、 邻苯二甲酸盐和增塑剂、酚类化合物、农药和芳香胺）通过生物监测测量 并根据广泛的公众暴露程度和空气和水中的环境污染物进行优先排序，并进行评估 通过地理信息系统对参与者的居住历史进行分析，我们的结果将集中于以下方面。 未来癌症发病风险的生物标志物包括： 短期结果侧重于与关键因素的关联 中等癌症风险生物标志物的特征（免疫反应和慢性炎症， 氧化应激和 DNA 损伤、激素破坏/受体介导的影响和细胞永生化）。 长期结果我们将把队列参与者与加州联邦基于人口的癌症登记处联系起来， 项目后期的出院数据、重要记录和 Medi-Cal 文件，以确定以下情况的诊断： 我们的多学科合作建立在我们广泛的知识和能力之上。 对怀孕期间的环境暴露和环境影响进行大规模研究的经验 我们提出的队列开发和研究计划将增进我们对癌症风险因素的理解。 地理和人口多样化的年轻群体中存在多种污染物暴露，因此 增进我们对与这些期间的具体结果相关的致癌物易感性增强的认识 关键和未充分研究的时期，结合一个平台，将允许灵活性和未来的合作 随着新科学的出现，加强我们的研究。