Sex Differences in Musculoskeletal Conditions across the Lifespan

整个生命周期中肌肉骨骼状况的性别差异

• 批准号: 8734220
• 负责人: Nancy E Lane
• 金额: $ 104.5万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-12 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8734220
• 关键词: Affect; Aging; Basic Science; Carpal Tunnel Syndrome; Clinical; Clinical Preventive Practices; Clinical Research; Cohort Studies; Communities; Degenerative polyarthritis; Development; Diagnosis; Epidemiologic Studies; Epidemiology; Exercise; Goals; Grant; Image; Incidence; Intervention; Knee Osteoarthritis; Kyphosis deformity of spine; Laboratories; Lead; Longevity; Medical; Musculoskeletal; Musculoskeletal Diseases; Operative Surgical Procedures; Osteoporosis; Physical activity; Physiology; Preventive; Primary Care Physician; Progesterone Receptors; Public Health; Quality of life; Randomized Clinical Trials; Regulation; Research; Research Personnel; Resolution; Severities; Sex Characteristics; Shapes; Specialized Center; Syndrome; Technology; Translating; Ultrasonography; United States; Visit; Woman; Women' s Health; base; bone; bone mass; clinical practice; continuing medical education; disability; epidemiologic data; innovation; meetings; men; novel diagnostics; outcome forecast; programs; prospective; randomized trial; response; sex; standard care

DESCRIPTION (provided by applicant): Musculoskeletal Diseases comprise the most frequent ailment for primary care physician visits in the United States, and the increases in incidence of musculoskeletal diseases with aging (particularly osteoporosis and osteoarthritis) is higher in women than in men, and leads to a significant amount of disability and reduced quality of life. Epidemiologic data clearly demonstrate the proportion of women affected my musculoskeletal diseases is higher than in men with aging, yet the biologic explanation for this sex difference remains unclear. The objective of this interdisciplinary, multi-institutional proposal, entitled "Sex Differences in Musculoskeletal Conditions Across the Lifespan," is to integrate cutting-edge basic science regarding sex differences in the physiology relate to acquiring peak bone mass, epidemiologic study on the relation of sex differences in bone shape to occurrence, severity and prognosis of osteoarthritis, clinical study of sex differences in high resolution ultrasound in diagnosis and prognosis of carpal tunnel syndrome with conservative and surgical treatment, and a randomized trial of sex differences in response to a physical activity intervention for kyphosis. The overarching goal of this Specialized Center of Research is to inform and transform preventive efforts and clinical practice in diagnosis and treatment of these musculoskeletal conditions in both sexes and lead to improvements in women's health. The four projects that compose the Center will conduct critical, innovative research to characterize sex differences in musculoskeletal conditions via: 1) a mechanistic study of sex differences in progesterone receptors that are related to regulation or influence peak bone mass, 2) a prospective clinical cohort study using novel diagnostic technology to examine sex differences in the results of this technology to diagnose carpal tunnel syndrome and sex differences in standard treatments for this condition, 3) an epidemiologic imaging study to assess sex differences in bone shape and the influence of bone shape on the development, severity and prognosis of osteoarthritis of the knee, and 4) a randomized clinical trial of sex differences in response to an exercise intervention for the treatment of kyphosis. The Center's research results will be translated to the local and national medical community's through presentations by Center researchers at a number of different forums, including UC Davis and UCSF continuing medical education programs, as well as local grand rounds and national meetings. PUBLIC HEALTH REFERENCE: This translational SCOR grant, "Sex Differences in Musculoskeletal Diseases Across the Lifespan," focuses on four musculoskeletal diseases or syndromes that differ by sex and include peak bone mass (a laboratory based project), carpal tunnel syndrome (epidemiologic and observational), osteoarthritis of the knee (observational), and kyphosis (exercise intervention). Each project will carefully determine the sex differences in relation to the musculoskeletal diseases and inform preventive and clinical practices.

描述（由申请人提供）：肌肉骨骼疾病包括美国初级保健医师就诊的最常见疾病，以及衰老的肌肉骨骼疾病的发病率增加（尤其是骨质疏松和骨关节炎）的疾病，女性比男性更高，铅是男性的铅大量残疾和生活质量降低。流行病学数据清楚地表明，影响我的肌肉骨骼疾病的妇女比例高于衰老的男性，但这种性别差异的生物学解释尚不清楚。这个跨学科的多机构提议的目的，标题为“整个生命周期中的肌肉骨骼状况的性别差异”，是为了整合有关生理学的性别差异的尖端基础科学，与获取峰值骨质量有关性别差异在发生骨关节炎的发生，严重程度和预后，对诊断高分辨率超声的性别差异的临床研究和保守和手术治疗的腕管综合征的预后以及对身体活动的性差异的随机试验的随机试验干预后脑。这个专业研究中心的总体目标是在性别中诊断和治疗这些肌肉骨骼状况的诊断和治疗方面的预防努力和临床实践，并导致妇女健康的改善。组成该中心的四个项目将进行关键的创新研究，以表征肌肉骨骼条件下的性别差异：1）与调节或影响峰值骨骼质量相关的孕激素受体的性别差异的机械研究，2）研究使用新型诊断技术检查该技术结果的性别差异，以诊断腕管综合征和此疾病标准治疗中的性别差异，3）一项流行病学成像研究，以评估骨骼形状的性别差异以及骨骼形状的影响膝盖骨关节炎的发育，严重程度和预后，以及4）性别差异的随机临床试验，以应对锻炼干预以治疗尾巴病。该中心的研究结果将通过中心研究人员在许多不同论坛上的演讲中转化为当地和国家医学界的，包括加州大学戴维斯分校和UCSF持续医学教育计划，以及当地的大回合和国家会议。 公共卫生参考：这项翻译得分赠款，“整个生命周期的肌肉骨骼疾病的性别差异”，重点是四种因性别而异的肌肉骨骼疾病或综合症，包括性别，包括峰值骨骼肿块（一个基于实验室的项目），腕管综合征（流行性和观察学和观察学和观察学和观察学和观察力学和观察），膝盖的骨关节炎（观测）和脑关节炎（运动干预）。每个项目将仔细确定与肌肉骨骼疾病有关的性别差异，并为预防性和临床实践提供信息。