The Study of Muscle, Mobility and Aging with Knee OA

膝关节 OA 的肌肉、活动度和衰老研究

• 批准号: 10257049
• 负责人: Nancy E Lane
• 金额: $ 68.7万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10257049
• 关键词: Affect; Age; Aging; Ancillary Study; Assessment tool; Autophagocytosis; Biological; Biopsy; Blood; Cartilage; Caucasians; Cell physiology; Characteristics; Clinical; Clinical Research; Communities; Contracts; Cross-Sectional Studies; Data; Degenerative polyarthritis; Denervation; Deterioration; Diagnostic radiologic examination; Disease; Elderly; Enrollment; Fatty acid glycerol esters; Follow-Up Studies; Funding; Gene Expression; Goals; Individual; Intervention; Intramuscular; Knee; Knee Osteoarthritis; Knee joint; Knowledge; Lateral; Lower Extremity; Measures; Muscle; Muscle Cells; Muscle Fibers; Muscle function; Musculoskeletal; Osteoporosis; Outcome Measure; Pain; Patient Self-Report; Persons; Prevalence; Property; Public Health; Reporting; Research; Research Design; Risk; Role; Skeletal Muscle; Testing; Thigh structure; Time; Tissues; United States National Institutes of Health; Visit; Walking; Weight-Bearing state; Woman; age related; base; clinical phenotype; disability; ethnic diversity; follow-up; functional outcomes; knee pain; knee replacement arthroplasty; men; muscle form; muscle strength; novel; oxidative damage; prevent; quadriceps muscle; reduced muscle mass; reduced muscle strength; walking speed; Affect; Age; Aging; Ancillary Study; Assessment tool; Autophagocytosis; Biological; Biopsy; Blood; Cartilage; Caucasians; Cell physiology; Characteristics; Clinical; Clinical Research; Communities; Contracts; Cross-Sectional Studies; Data; Degenerative polyarthritis; Denervation; Deterioration; Diagnostic radiologic examination; Disease; Elderly; Enrollment; Fatty acid glycerol esters; Follow-Up Studies; Funding; Gene Expression; Goals; Individual; Intervention; Intramuscular; Knee; Knee Osteoarthritis; Knee joint; Knowledge; Lateral; Lower Extremity; Measures; Muscle; Muscle Cells; Muscle Fibers; Muscle function; Musculoskeletal; Osteoporosis; Outcome Measure; Pain; Patient Self-Report; Persons; Prevalence; Property; Public Health; Reporting; Research; Research Design; Risk; Role; Skeletal Muscle; Testing; Thigh structure; Time; Tissues; United States National Institutes of Health; Visit; Walking; Weight-Bearing state; Woman; age related; base; clinical phenotype; disability; ethnic diversity; follow-up; functional outcomes; knee pain; knee replacement arthroplasty; men; muscle form; muscle strength; novel; oxidative damage; prevent; quadriceps muscle; reduced muscle mass; reduced muscle strength; walking speed

PROJECT SUMMARY / ABSTRACT Deterioration of musculoskeletal tissues with age results in osteoarthritis, reduced mobility, and increased disability. Osteoarthritis (OA) frequently affects the knee and is the leading cause of disability worldwide. Poor muscle characteristics are associated with knee OA (KOA) and cross-sectional comparisons of healthy controls and KOA subjects show differences in muscle composition, quadriceps muscle strength and power. A few, small cross-sectional studies have also rigorously investigated muscle qualities associated with reduced mobility in older adults, independent of KOA, and reported reduced muscle mass, decreased ability to generate ATP, denervation, oxidative damage, and decreased autophagy. However, these clinical studies have been small, only cross-sectional, and often did not include individuals at risk for immobility or documented KOA. How these muscle qualities change with KOA is not known and represents a roadblock to understanding reduced mobility and increased disability in KOA. The NIA/NIH recently funded a Study of Muscle, Mobility and Aging (SOMMA), which just began enrolling 875 intermediate functioning, ethnically diverse women and men age >=70yrs. at two centers. The SOMMA study aims to 1) understand the contributions of skeletal muscle mass, energetics, and key properties of muscle tissue from biopsies to major immobility and disability; and 2) produce a unique bank of muscle tissue, blood, gene expression data, and clinical phenotyping to be used by the scientific community. We propose to obtain knee radiographs at the first SOMMA follow-up visit to understand the contributions of skeletal muscle mass and composition that leads to reduced mobility and disability in KOA subjects and if this differs from subjects without KOA. The Specific Aims are: Aim 1. Compare the baseline muscle properties (muscle strength, power, composition, ATPmax) in individuals with vs. without radiographic KOA, and with vs. without symptomatic KOA (radiographic KOA and pain). We will test the hypothesis that these muscle properties differ in subjects with radiographic KOA and symptomatic KOA compared to individuals without KOA (with and without pain). Aim 2. Determine whether radiographic KOA and symptomatic KOA are associated with functional outcomes (400m walking speed and Mobility Assessment Tool- short form, MAT-sf Disabiilty) independently of muscle characteristics (muscle strength, power and composition, ATPmax). We will test the hypothesis that persons with radiographic KOA and symptomatic KOA will have worse functional outcomes independent of muscle characteristics. Aim 3. Compare the association of muscle characteristics (composition, strength, power, ATPmax) with functional outcomes (400m walking speed and MAT-sf disability) in subjects with and without KOA, and with and without symptomatic KOA. We will test the hypothesis that the association of muscle characteristics with functional outcomes is different in subjects with, and without radiographic KOA and with and without symptomatic KOA.

项目摘要 /摘要 随着年龄的增长，肌肉骨骼组织恶化会导致骨关节炎，迁移率降低并增加 残疾。骨关节炎（OA）经常影响膝盖，是全球残疾的主要原因。贫穷的 肌肉特征与膝盖OA（KOA）和健康的横截面比较有关 控制和KOA受试者在肌肉组成，股四头肌的肌肉力量和力量方面表现出差异。一个 很少有小的横断面研究严格研究了与降低的肌肉质量 老年人的移动性，独立于KOA，报告肌肉质量减少，产生能力降低 ATP，神经保护，氧化损伤和自噬减少。但是，这些临床研究已经 小的，只有横截面，通常不包括有毒性危险或记录为KOA的人。如何 这些肌肉品质随KOA的变化而变化，这是理解减少的障碍 KOA的流动性和残疾增加。 NIA/NIH最近资助了肌肉，流动性和衰老的研究 （Somma），刚刚开始注册875个中间功能，种族多样化的男女 > = 70yrs。在两个中心。 SOMMA研究的目的是1）了解骨骼肌质量的贡献， 肌肉组织从活检到主要不动和残疾的关键特性； 2）生产 独特的肌肉组织，血液，基因表达数据和临床表型，用于使用 科学界。我们建议在第一次Somma随访时获得膝盖X光片以了解 骨骼肌质量和成分的贡献，导致KOA的迁移率和残疾降低 受试者以及这与没有KOA的受试者不同。具体目的是：目标1。比较基线 肌肉特性（肌肉力量，力量，成分，ATPMAX） KOA，没有症状的KOA（放射学KOA和疼痛）。我们将检验以下假设 这些肌肉特性在射线照相KOA和有症状的KOA受试者中不同 没有KOA的个人（有和没有疼痛）。目标2。确定射线照相和有症状是否 KOA与功能结果相关（400m步行速度和移动性评估工具 - 短形式， MAT-SF不稳定）独立于肌肉特征（肌肉力量，力量和组成，ATPMAX）。 我们将检验以下假设，即具有射线照相和有症状KOA的人会更糟 功能结果与肌肉特征无关。目标3。比较肌肉的关联 具有功能结果的特征（组成，力量，力量，ATPMAX）（400m步行速度和 MAT-SF残疾）在有或没有KOA的受试者中，并且有症状性KOA。我们将测试 假设肌肉特征与功能结果的关联在患有， 并且没有射线照相KOA，并且没有症状的KOA。