A Longitudinal Study of Adopted Youth and Their Families

被收养青少年及其家庭的纵向研究

基本信息

批准号：
8399093
负责人：
MATTHEW K. MCGUE
金额：
$ 41.87万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-03-10 至 2015-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8399093
关键词：
Address Adolescence Adolescent Adopted Adoption Adult Affect Age Alcohol abuse Alcohol or Other Drugs use Antisocial Personality Disorder Anxiety Anxiety Disorders Attention deficit hyperactivity disorder Behavior Behavioral Childhood Comorbidity Conduct Disorder Data Dependence Development Diagnostic and Statistical Manual Dimensions Disease Economics Environment Environmental Risk Factor Etiology Family Family Relationship Family Study Funding Genetic Health Home environment Individual Infant Inherited Intake Intervention Investigation Lead Left Life Life Stress Literature Longitudinal Studies Mediating Mental Depression Mental Health Mental disorders Methods Nature Neighborhoods Outcome Parents Pattern Peer Group Personality Play Positioning Attribute Preventive Problem behavior Progress Reports Psychopathology Public Health Randomized Research Risk Risk Assessment Risk Marker Role Sampling Sampling Studies Siblings Source Stress Substance Use Disorder Substance abuse problem Telephone Interviews Testing Time Youth adolescent alcohol adolescent alcohol abuse alcohol misuse anti social base cohort design emerging adult follow-up infancy innovation longitudinal design maternal depression middle age neurotoxic novel offspring programs social transmission process underage drinking young adult

项目摘要

DESCRIPTION (provided by applicant): This application seeks renewal funding for a unique and innovative longitudinal study of adopted and non-adopted families. The Sibling Interaction and Behavior Study (SIBS) includes 409 adopted and 208 non-adopted families. At intake, each family consisted of pair of adolescent siblings and their rearing parents, a total of 2394 individuals. SIBS offspring have completed an intake assessment in mid-adolescence, a first follow-up (FU1) assessment in late-adolescence, and are in the midst of a second follow-up (FU2) assessment in early adulthood. Rate of participation at FU1 and to date in FU2 is well above 90 percent. Intake and FU assessments are extensive and include: 1) comprehensive assessment of common externalizing (e.g., conduct disorder, substance use disorders, ADHD) and internalizing (depression, anxiety disorders) psychopathology; 2) substance use, abuse, and dependence; 3) individual-level markers of risk (personality, academic ability and progress); 4) family relationships (both parent-offspring and sibling); and 5) other environmental risk factors (e.g., peer group, religiousness, life stress, neighborhood). The current application has 4 specific aims, to: 1) complete the FU2 assessment, 2) analyze FU1 and FU2 data to determine the nature of familial risk for common mental disorders; 3) use the principle of Mendelian Randomization to test the effect of adolescent alcohol use and misuse on risk of mental health and substance use disorders in early adulthood; and 4) determine whether individuals adopted in infancy are at heightened risk for mental disorders as young adults. Analysis of SIBS intake data demonstrates that this is a unique study that is making important observations on, for example, the effect of maternal depression, the impact of parent antisocial behavior, the consequences of adolescent alcohol abuse, and the mental health of US adopted youth. Continued support for this program of research will allow us to chart the trajectory of the development of common mental disorders from mid-adolescence through early adulthood, using an adoption design that allows us to identify familial environmental as well as genetic contributions to risk.

描述（由申请人提供）：本申请寻求续期资金，以对收养和非收养家庭进行独特且创新的纵向研究。兄弟姐妹互动和行为研究 (SIBS) 包括 409 个收养家庭和 208 个非收养家庭。入学时，每个家庭由一对青少年兄弟姐妹及其抚养父母组成，总共 2394 人。 SIBS 后代在青春期中期完成了摄入评估，在青春期后期完成了第一次随访 (FU1) 评估，并正在成年早期进行第二次随访 (FU2) 评估。 FU1 和迄今为止 FU2 的参与率远高于 90%。摄入量和 FU 评估范围广泛，包括：1）常见外化（例如行为障碍、物质使用障碍、多动症）和内化（抑郁、焦虑症）精神病理学的综合评估； 2) 物质使用、滥用和依赖； 3）个人层面的风险标记（个性、学术能力和进步）； 4）家庭关系（亲子关系和兄弟姐妹关系）； 5) 其他环境风险因素（例如同侪群体、宗教信仰、生活压力、邻里关系）。当前的应用程序有 4 个具体目标，即：1) 完成 FU2 评估，2) 分析 FU1 和 FU2 数据以确定常见精神障碍家族风险的性质； 3）利用孟德尔随机化原理来测试青少年饮酒和滥用酒精对成年早期心理健康和物质使用障碍风险的影响； 4) 确定婴儿期收养的个体在年轻时是否面临较高的精神障碍风险。对 SIBS 摄入数据的分析表明，这是一项独特的研究，对母亲抑郁的影响、父母反社会行为的影响、青少年酗酒的后果以及美国收养青少年的心理健康等进行了重要观察。。对该研究计划的持续支持将使我们能够利用收养设计来绘制从青春期中期到成年早期的常见精神障碍的发展轨迹，使我们能够识别家庭环境以及遗传对风险的影响。