Adolescent drinking and midlife outcomes: A prospective cotwin control study

青少年饮酒与中年结局：一项前瞻性 cotwin 对照研究

基本信息

批准号：
10625299
负责人：
MATTHEW K. MCGUE
金额：
$ 60.9万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-04-10 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10625299
关键词：
Achievement Acute Address Adolescence Adolescent Adult Age Alcohol consumption Alcohol dependence Alcoholic beverage heavy drinker Alcohols Antisocial Personality Disorder Behavior Characteristics Data Data Analyses Deposition Development Disease Education Elderly Environmental Risk Factor Evaluation Family Study Gender Genetic Habits Heavy Drinking Individual Instruction Investigation Left Length Life Life Stress Link Literature Long-Term Effects Longitudinal Studies Medical Mental Depression Mental Health Methods Minnesota Modeling Neurocognitive Occupational Outcome Patient Self-Report Pattern Persons Predisposition Prospective Studies Prospective, cohort study Research Research Design Research Personnel Risk Risk Factors Role Social Functioning Social isolation Spouses Substance abuse problem Surveys Testing Twin Multiple Birth Twin Studies Woman Youth alcohol poisoning automobile accident behavioral disinhibition binge drinking cognitive function cohort comorbidity course development design drinking early drinking emerging adult experimental study follow-up gender difference high-risk adolescents innovation longitudinal design member men middle age physical conditioning prospective psychosocial public repository sexual victimization social substance use telomere underage drinking

项目摘要

ORIGINAL ABSTRACT Adolescence is a period when many individuals begin to experiment with alcohol, with some progressing rapidly to abusive drinking. The acute problems associated with heavy adolescent alcohol use (e.g., alcohol poisoning, sexual victimization, automobile accidents) have been well documented; less certain is whether adolescent alcohol use also has long-term consequences. Three recent reviews of the relevant literature have come to similar conclusions: adolescent drinking is associated with adult functioning, but the existing literature does not tell us whether these associations are causal or whether the consequences of adolescent drinking are long-lasting. We propose to address these limitations with a prospective study of a unique cohort of twins. These twins were initially assessed at age 17, at the early stages of alcohol use, and again at age 20, the period in adolescence when alcohol use peaks. They were subsequently assessed at ages 24 and 29, a period characterized by life-role transition. We now propose to assess them at mid-life (average age of 42 years), a developmental period characterized by stability and for most a moderation of youthful patterns of heavy drinking. The in-person assessment will cover 4 major domains of functioning: 1) mental health, including substance use and abuse, 2) physical health and behavior, 3) neurocognitive function, and 4) psychosocial outcomes including educational and occupational achievement and relationship quality. We estimate that 1130 twins will participate (greater than 90% of the surviving members of the original cohort) in the in-person assessment and that 910 of their spouses/partners will also complete a brief mail survey. Analysis of the data will document the range of adult outcomes associated with adolescent drinking and evaluate three alternative models to account for these effects: 1) the factors that lead to early and heavy drinking in adolescence also increase the likelihood of deficits in adulthood (i.e., confounding), 2) adolescent heavy drinkers tend to become adult heavy drinkers (i.e., drinking persistence), and 3) adolescent drinking upsets the normal course of adult. The innovative cotwin control design, which controls for genetic and shared environmental factors on outcomes, will help isolate possible causal effects of adolescent drinking on midlife functioning. The extensive earlier assessments of this cohort will provide a wealth of information for propensity score D RELEVANCE (See instructions): The project follows a large cohort of twins from age 17 to age 36-44 to identify the consequences of heavy and abusive drinking in adolescence for functioning in mid-life. The project seeks to determine the extent to which adolescent drinking impacts mental health, physical health, cognitive and social functioning in mid-life and the extent to which any effects can be ameliorated by drinking desistence.

原摘要青春期是许多人开始尝试饮酒的时期，其中一些人正在进步迅速发展为酗酒。与青少年大量饮酒相关的严重问题（例如，酒精中毒、性受害、车祸）都有详细记录；不太确定的是青少年饮酒是否也会产生长期后果。最近的三篇相关评论文献得出了类似的结论：青少年饮酒与成人功能有关，但是现有文献并没有告诉我们这些关联是否是因果关系或者后果是否的青少年饮酒是长期的。我们建议通过前瞻性研究来解决这些局限性一群独特的双胞胎。这些双胞胎在 17 岁时接受了初步评估，当时正处于酗酒的早期阶段饮酒，然后在 20 岁时再次饮酒，这是青春期饮酒的高峰期。他们随后被在 24 岁和 29 岁进行评估，这是一个以生活角色转变为特征的时期。我们现在建议评估他们正处于中年（平均年龄 42 岁），这是一个以稳定为特征的发展时期，对大多数人来说年轻人酗酒的节制现场评估将涵盖4个主要领域功能：1) 心理健康，包括药物使用和滥用，2) 身体健康和行为，3) 神经认知功能，以及 4) 心理社会结果，包括教育和职业成就和关系质量。我们预计将有 1130 名双胞胎参加（超过 90%）第910章配偶/伴侣还将完成一份简短的邮件调查。数据分析将记录范围与青少年饮酒相关的成人结局，并评估三种替代模型来解释这些影响：1）导致青春期过早饮酒和大量饮酒的因素也会增加成年期出现缺陷的可能性（即混杂），2) 青少年酗酒者往往会成年大量饮酒者（即持续饮酒），以及3）青少年饮酒扰乱了成人的正常过程。创新的 cotwin 控制设计，可控制基因和共享环境因素结果，将有助于找出青少年饮酒对中年功能可能产生的因果影响。这对该群体进行广泛的早期评估将为倾向评分提供丰富的信息 D 相关性（参见说明）：该项目跟踪了一大群年龄从 17 岁到 36-44 岁的双胞胎，以确定为了中年的机能而在青春期大量酗酒。该项目旨在确定青少年饮酒对心理健康、身体健康、认知和社交的影响程度中年时的功能以及戒酒可以在多大程度上改善任何影响。