Early Life Adversity, Sleep, and Cardiovascular Risk in Black and White Men

黑人和白人的早年逆境、睡眠和心血管风险

• 批准号: 8708191
• 负责人: KAREN MATTHEWS
• 金额: $ 70.16万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8708191
• 关键词: 6 year old; Academic achievement; Accounting; Adolescence; Adult; Advocate; Affect; Age; American; American Heart Association; Behavior; Behavioral; Biological Markers; Blood Pressure; Blood Vessels; Body Size; Cardiovascular Diseases; Cardiovascular system; Censuses; Cessation of life; Characteristics; Child; Child Abuse and Neglect; Childhood; Cholesterol; Communities; Crime; Deterioration; Development; Discipline; Disease; Economics; Enrollment; Environment; Ethnic Origin; Event; Exhibits; Exposure to; Family; Generations; Glucose; Goals; Health; Health behavior; Healthy People 2020; Household; Hypertension; Individual; Intervention; Knowledge; Label; Life; Life Cycle Stages; Life Experience; Longevity; Longitudinal Studies; Measures; Metabolic syndrome; Mus; Neighborhoods; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Parenting behavior; Parents; Participant; Pattern; Physical activity; Premature Mortality; Psychosocial Factor; Race; Resources; Risk Factors; Sleep; Socioeconomic Status; Solid; Staging; Stress; Stroke; Testing; Time; Violence; Weather; Woman; Youth; actigraphy; base; cardiovascular disorder prevention; cardiovascular disorder risk; cardiovascular risk factor; clinically relevant; critical period; design; early life exposure; experience; first grade; good diet; health disparity; health equity; heart rate variability; improved; low socioeconomic status; male; men; middle age; mortality; parental monitoring; peer; population based; prevent; psychosocial; public health relevance; racial and ethnic disparities; skills; social; social skills; stem

DESCRIPTION (provided by applicant): Black men suffer disproportionately from premature mortality and cardiovascular disease (CVD) compared to their white counterparts, perhaps in part due to blacks' greater exposure to social and economic adversity across the life span as suggested by the weathering hypothesis. This application suggests that (a) black-white differences in CVD in adulthood stem from cumulative adversity correlated with race much earlier in life; and (b) early life exposures at the individual, family, and neighborhood level mus be considered simultaneously. Not emphasized in the weathering hypothesis is that intra- and inter-personal and cultural resources also may accumulate over the life course (labeled reserve capacity) and moderate effects of early life adversity; and that there may also be a critical perio exposure to adverse life events. Sleep may be an important factor here because of its likely relation to race and socioeconomic status (SES), and possibly to CVD events. This application focuses on the developmental antecedents of sleep, optimal cardiovascular (CV) health (defined by AHA criteria), and CVD risk in a population-based study of middle-aged black and white men who have been followed since they were enrolled in the first grade. They have been assessed repeatedly for health behaviors and academic and social competence; parent health behaviors, parenting practices, and household SES; and neighborhood characteristics, including census track SES, violence exposure, and community cohesiveness and involvement; these measures have been summarized into developmentally appropriate periods. In 300 men now in their late thirties, we propose to collect measures of CV biomarkers and psychosocial risk factors and sleep to test the following: 1) the extent of black/white differences in sleep, optimal CV health, and CVD risk, and sleep; 2) whether early adverse family and neighborhood environments, particularly during adolescence, predict adult optimal CV health, CVD risk, and sleep; and 3) if reserve capacity reduces the impact of early adverse environments. Knowledge gained from this project may identify the early life experiences and their timing that render black men particularly vulnerable to later CVD.

描述（由申请人提供）：黑人与白人对应物相比，黑人因过早死亡率和心血管疾病（CVD）的痛苦不成比例，这可能部分是由于黑人在整个生活范围内更大的暴露于风化假设所暗示的整个生活跨度。该应用表明，（a）成年中CVD的黑白差异源于与种族相关的累积逆境； （b）同时考虑对个人，家庭和邻里水平的早期生活暴露。在风化假设中不强调的是，人体内和文化资源也可能积累在生命过程中（标记为储备金能力）和早期生命逆境的适度影响。并且可能会有至关重要的perio暴露于不良生活事件。睡眠可能是这里的重要因素，因为它可能与种族和社会经济地位（SES）以及可能与CVD事件有关。该应用的重点是睡眠的发育前因，最佳心血管（CV）健康（由AHA标准定义）和CVD风险在基于人群的中年黑人和白人研究的研究中，自从他们入学以来，他们就遵循了遵循的中年白人和白人。一年级。他们已反复评估健康行为以及学术和社会能力；父母的健康行为，育儿做法和家庭SES；和社区特征，包括人口普查，暴力暴露以及社区的凝聚力和参与；这些措施已被总结为发育适当的时期。在三十多岁的300名男性中，我们建议收集简历生物标志物和社会心理风险因素的措施，并睡眠测试以下测试：1）睡眠，最佳CV健康和CVD风险的黑色/白人差异的程度以及睡眠的程度; 2）早期不良家庭和邻里环境，尤其是在青春期，可以预测成人最佳的简历健康，CVD风险和睡眠； 3）如果储备能力减少了早期不利环境的影响。从这个项目中获得的知识可能会确定早期的生活经历及其时机，使黑人特别容易受到后期CVD的影响。

项目成果

Prospective Associations of Parenting and Childhood Maltreatment with Personality in Adolescent Males.

• DOI: 10.1111/jora.12613
• 发表时间: 2021-04
• 期刊: Journal of research on adolescence : the official journal of the Society for Research on Adolescence
• 作者: J. Cundiff;K. Duggan;Mengya Xia;K. Matthews