Early Life Adversity, Sleep, and Cardiovascular Risk in Black and White Men

黑人和白人的早年逆境、睡眠和心血管风险

基本信息

批准号：
8366645
负责人：
KAREN MATTHEWS
金额：
$ 73.84万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-08-15 至 2015-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8366645
关键词：
6 year old Academic achievement Accounting Adolescence Adult Advocate Affect Age American American Heart Association Behavior Behavioral Biological Markers Blood Pressure Blood Vessels Body Size Cardiovascular Diseases Cardiovascular system Censuses Cessation of life Characteristics Child Child Abuse and Neglect Childhood Cholesterol Communities Crime Deterioration Development Discipline Disease Economics Enrollment Environment Ethnic Origin Event Exhibits Exposure to Family Generations Glucose Goals Health Health behavior Healthy People 2020 Household Hypertension Individual Intervention Knowledge Label Life Life Cycle Stages Life Experience Longevity Longitudinal Studies Measures Metabolic syndrome Mus Neighborhoods Non-Insulin-Dependent Diabetes Mellitus Obesity Outcome Parenting behavior Parents Participant Pattern Physical activity Premature Mortality Psychosocial Factor Race Resources Risk Factors Sleep Socioeconomic Status Solid Staging Stress Stroke Testing Time Violence Weather Woman Youth actigraphy base cardiovascular disorder prevention cardiovascular disorder risk cardiovascular risk factor clinically relevant critical period design early life exposure experience first grade good diet health disparity health equity heart rate variability improved low socioeconomic status male men middle age mortality parental monitoring peer population based prevent psychosocial racial and ethnic disparities skills social social skills stem

项目摘要

DESCRIPTION (provided by applicant): Black men suffer disproportionately from premature mortality and cardiovascular disease (CVD) compared to their white counterparts, perhaps in part due to blacks' greater exposure to social and economic adversity across the life span as suggested by the weathering hypothesis. This application suggests that (a) black-white differences in CVD in adulthood stem from cumulative adversity correlated with race much earlier in life; and (b) early life exposures at the individual, family, and neighborhood level mus be considered simultaneously. Not emphasized in the weathering hypothesis is that intra- and inter-personal and cultural resources also may accumulate over the life course (labeled reserve capacity) and moderate effects of early life adversity; and that there may also be a critical perio exposure to adverse life events. Sleep may be an important factor here because of its likely relation to race and socioeconomic status (SES), and possibly to CVD events. This application focuses on the developmental antecedents of sleep, optimal cardiovascular (CV) health (defined by AHA criteria), and CVD risk in a population-based study of middle-aged black and white men who have been followed since they were enrolled in the first grade. They have been assessed repeatedly for health behaviors and academic and social competence; parent health behaviors, parenting practices, and household SES; and neighborhood characteristics, including census track SES, violence exposure, and community cohesiveness and involvement; these measures have been summarized into developmentally appropriate periods. In 300 men now in their late thirties, we propose to collect measures of CV biomarkers and psychosocial risk factors and sleep to test the following: 1) the extent of black/white differences in sleep, optimal CV health, and CVD risk, and sleep; 2) whether early adverse family and neighborhood environments, particularly during adolescence, predict adult optimal CV health, CVD risk, and sleep; and 3) if reserve capacity reduces the impact of early adverse environments. Knowledge gained from this project may identify the early life experiences and their timing that render black men particularly vulnerable to later CVD. PUBLIC HEALTH RELEVANCE: Understanding the developmental antecedents of poor sleep and cardiovascular risk in black and white men will facilitate the design and timing of interventions to prevent adverse health consequences of early life experiences. This project will facilitate reaching two overarching goals of Healthy People 2020: a) achieving health equity and eliminating health disparities; and b) promoting healthy development and healthy behaviors across all life stages.

描述（由申请人提供）：与白人男性相比，黑人男性过早死亡和心血管疾病（CVD）的比例过高，部分原因可能是由于风化假说所表明的，黑人在一生中更容易遭受社会和经济逆境的影响。该应用表明，(a) 成年期 CVD 的黑人和白人差异源于与生命早期种族相关的累积逆境； (b) 必须同时考虑个人、家庭和邻里层面的早期生活暴露。风化假说中没有强调的是，个人内部和人际关系以及文化资源也可能在生命历程中积累（标记为储备能力）以及早期生活逆境的适度影响；并且还可能在关键时期暴露于不良生活事件。睡眠可能是一个重要因素，因为它可能与种族和社会经济地位 (SES) 以及 CVD 事件有关。该应用程序重点关注一项基于人群的中年黑人和白人研究中的睡眠、最佳心血管 (CV) 健康（由 AHA 标准定义）和 CVD 风险的发展因素，这些研究自入组以来一直受到跟踪。一年级。他们的健康行为、学术和社交能力都经过反复评估；父母健康行为、养育方式和家庭社会经济地位；社区特征，包括人口普查追踪社会经济地位、暴力暴露以及社区凝聚力和参与度；这些措施已被归纳为适合发展的时期。我们建议在 300 名三十多岁的男性中收集心血管生物标志物、心理社会风险因素和睡眠的测量结果，以测试以下内容：1) 睡眠、最佳心血管健康、心血管疾病风险和睡眠方面的黑人/白人差异程度; 2) 早期不利的家庭和邻里环境，特别是在青春期，是否可以预测成人最佳的心血管健康、心血管疾病风险和睡眠； 3）储备能力是否减少了早期不利环境的影响。从这个项目中获得的知识可能会确定黑人的早期生活经历及其发生的时间，这些经历使黑人特别容易患上心血管疾病。公共卫生相关性：了解黑人和白人睡眠不良和心血管风险的发展因素将有助于干预措施的设计和时机安排，以防止早期生活经历对健康造成不良后果。该项目将促进实现“健康人民 2020”的两个总体目标：a) 实现健康公平和消除健康差距； b) 促进各个生命阶段的健康发展和健康行为。