Drug Abuse Vulnerability: Mechanisms and Manifestations

药物滥用脆弱性：机制和表现

基本信息

批准号：
8445282
负责人：
RALPH E TARTER
金额：
$ 181.08万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-05-01 至 2015-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8445282
关键词：
12 year old Administrator Age Alcohol or Other Drugs use Alcohols Applications Grants Basic Science Behavior Biological Books Budgets Caffeine Cannabis Categories Characteristics Child Clinical Clinical Engineering Clinical Research Collaborations Consumption DSM-IV Data Daughter Development Diagnostic Discipline Disease Doctor of Medicine Doctor of Philosophy Drug abuse Drug usage Eating Education Enrollment Ensure Environment Environmental Risk Factor Ethics Etiology Evaluation Event Exercise Expenditure Faculty Family Family member Fathers Frequencies Funding Genetic Goals Grant Guide prevention Illicit Drugs Individual Interdisciplinary Study Investigation Journals K-Series Research Career Programs Laws Leadership Legal Link Literature Master of Public Health Measurement Mental disorders Mission Modeling Monitor Mothers NIH Program Announcements Names National Institute of Drug Abuse National Institute of Neurological Disorders and Stroke Neurobiology Nursing Faculty Outcome Pattern Pharmaceutical Preparations Pilot Projects Policies Populations at Risk Postdoctoral Fellow Prevention Procedures Process Protocols documentation Provider Psychological reinforcement Psychopathology Publications Recommendation Recruitment Activity Research Research Institute Research Training Resources Review Committee Risk Safety Science Services Severities Son Staging Stepparent Students Substance Use Disorder Supervision System Testing Time Tobacco Training Training and Education Translations United States National Institutes of Health Variant Youth addiction arm base biobehavior design didactic education drug abuse education endophenotype experience follow-up foot high risk human disease illegal behavior implementation research indexing insight instrumentation men neurogenetics non-drug offspring proband programs prospective psychologic public health relevance response social norm statistics theories transmission process

项目摘要

DESCRIPTION (provided by applicant): This competing renewal application proposes to continue the follow-up research on 775 families enrolled in the Center's prospective investigations into the etiology of substance use disorder (SUD). The probands are men with lifetime presence/absence of SUD consequent to use of an illicit drug who have a 10-12 year old biological son or daughter. The biological children of SUD men are assigned to the high average risk (HAR) group whereas offspring of men without SUD, having neither axis 1 disorder ("normal") nor SUD psychiatric disorder, are assigned to the low average risk (LAR) groups. These children are currently in varying stages of follow-up evaluation conducted at ages 12-14, 16, 19, and annually thereafter until age 30. We have already shown that we can predict in 10-12 year old youth cannabis use disorder by age 22 with approximately 70% accuracy, thereby substantiating the paradigm, subject recruitment strategy and measurement protocols. Multidisciplinary research is conducted on family members (father, mother, children, step-parents) with the objective of elucidating the genetic, biobehavioral and environmental factors on development of SUD consequent to use of illegal drugs. Research protocols are organized into three thematically connected research modules (Neurogenetics. Developmental Psychopathology, and Translation) linking etiology and prevention. The research components thus align with the NIH Roadmap model such that basic science informs clinical research leading to prevention guided by an understanding of etiology. In addition to module-level research, faculty also participate in 3 centerwide aims: 1) Devise a practical scale to quantify the transmissible liability to SUD; 2) Empirically test a biopsychological theory of SUD etiology focusing on off time maturation leading to psychological dysregulation predisposing to SUD; and, 3) Delineate SUD liability variants within an ontogenetic framework. The Center has the program name Center for Education and Drug Abuse Research (CEDAR). It consists of six components (3 cores & 3 research modules): 1) Science Administration (R. Tarter, Ph.D.), 2) Clinical Core (J. Cornelius, M.D.), 3) Statistics Core (L. Kirisci, Ph.D.), 4) Neurogenetics Module (M. Vanyukov, Ph.D.) 5) Developmental Psychopathology Module (D. Clark, M.D., Ph.D.), and 6) Translation Module (Ty Ridenour, Ph.D.). Vertical and horizontal integration of the Center's components promote collaborative research encompassing multiple disciplines. To date, this research program has supported over 360 publications, 4 books, and 3 special journal issues as well as the training of numerous students, faculty and fellows. Six K awards are currently funded using CEDAR resources.

描述（由申请人提供）：本次竞争更新申请拟继续对参加该中心物质使用障碍 (SUD) 病因学前瞻性调查的 775 个家庭进行后续研究。先证者是因使用非法药物而终身存在/不存在 SUD 的男性，他们有一个 10-12 岁的亲生儿子或女儿。 SUD 男性的亲生子女被分配到高平均风险 (HAR) 组，而没有 SUD、既没有轴 1 疾病（“正常”）也没有 SUD 精神疾病的男性的后代被分配到低平均风险 (LAR) 组。这些儿童目前处于不同阶段的随访评估，在 12-14 岁、16 岁、19 岁期间进行，此后每年进行一次直至 30 岁。我们已经表明，我们可以按年龄预测 10-12 岁青少年大麻使用障碍22 的准确性约为 70%，从而证实了范式、受试者招募策略和测量协议。对家庭成员（父亲、母亲、子女、继父母）进行多学科研究，目的是阐明因使用非法药物而导致 SUD 发展的遗传、生物行为和环境因素。研究方案分为三个主题相关的研究模块（神经遗传学、发育精神病理学和翻译），将病因学和预防联系起来。因此，研究内容与 NIH 路线图模型保持一致，以便基础科学为临床研究提供信息，从而在了解病因学的基础上进行预防。除了模块级研究外，教师还参与 3 个中心目标： 1) 设计一个实用量表来量化 SUD 的可传递责任； 2) 实证检验 SUD 病因学的生物心理学理论，重点关注休息时间成熟导致易患 SUD 的心理失调； 3) 在个体发生框架内描述 SUD 责任变体。该中心的项目名称为教育和药物滥用研究中心 (CEDAR)。它由六个部分组成（3 个核心和 3 个研究模块）：1）科学管理（R. Tarter，博士），2）临床核心（J. Cornelius，医学博士），3）统计核心（L. Kirisci，博士), 4) 神经遗传学模块 (M. Vanyukov, 博士) 5) 发展精神病理学模块 (D. Clark, 医学博士, 博士), 和 6)翻译模块（Ty Ridenour 博士）。该中心各组成部分的纵向和横向整合促进了多学科的合作研究。迄今为止，该研究项目已支持超过 360 种出版物、4 本书和 3 期特刊，并培训了众多学生、教师和研究员。目前有 6 个 K 奖由 CEDAR 资源资助。