Longitudinal Modeling of SUD Etiology

SUD 病因学的纵向建模

• 批准号: 8824497
• 负责人: RALPH E TARTER
• 金额: $ 13.57万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8824497
• 关键词: 12 year old; Accounting; Advocacy; Affect; Age; Algorithms; Award; Behavior; Brain; Childhood; Cognition; Cognitive; Communities; Data; Data Set; Detection; Development; Disinhibition; Emotions; Empirical Research; Environment; Ethnic Origin; Etiology; Event; Family; Functional disorder; Funding; Gender; Goals; Individual; International; Investigation; Leadership; Life; Mediating; Medicine; Methods; Modeling; Monitor; National Institute of Drug Abuse; Neighborhoods; Outcome; Pathway interactions; Pattern; Persons; Phenotype; Prefrontal Cortex; Prevention; Prevention Research; Prevention strategy; Preventive Intervention; Probability; Process; Property; Psychometrics; Publishing; Reporting; Research; Risk; Schools; Science; Severities; Social Policies; Societies; Subgroup; Substance Use Disorder; Synapses; Time; United States National Institutes of Health; Youth; addiction; career; cognitive capacity; design; disorder risk; drug abuse education; high risk; improved; indexing; innovation; intervention program; longitudinal database; member; neural circuit; neurobehavior; neurobehavioral; neuroimaging; patient oriented; peer; programs; psychologic; response; theories; tool; young adult

DESCRIPTION (provided by applicant): The proposed investigations extend the applicant's research program directed at elucidating the etiology of substance use disorder (SUD). Utilizing almost 25 years of already collected longitudinal data and data to be collected during the next several years in this ongoing NIDA-funded Center for Education and Drug Abuse Research (CEDAR), analyses will be directed at joining individual vulnerability (particularly neurobehavior disinhibition, ND) and multiple facets of the environment to model the pathway(s) to SUD between ages 10-25. Neurobehavior disinhibition (encompassing the cognitive, affect and behavior components of psychological dysregulation) has been shown in 12 published reports I: i) have excellent psychometric properties (including predictive validity); ii) be informative for modeling SUD etiology in a developmental framework; iii) define a very high risk subset of 10-12 year olds having .95 probability of developing SUD; iv) correlate with electrophysiological and neuroimaging variables reflecting prefrontal cortex dysfunction; and, v) mediate adverse family, peer and neighborhood influences on SUD risk. This award will enable me to reallocate many of my day-to-day responsibilities while retaining leadership as the Center's PI. This award will provide me protected time for research integrating over two decades of accrued data for comprehensive analysis. This research is thematically guided, empirically grounded, and innovative in at least five ways: i) it captures SUD vulnerability integrating cognition, emotion, and behavior; ii) it integratively incorporates diverse age- appropriate environment influences; ii) it provides the opportunity to determine if there is differential salience of the various component of individual vulnerability and environment across the main age span of SUD development; iv) it is the first attempt to determine whether a composite index depicting a specific "environtype" at each age predisposes to SUD; and, v) employs item response theory (IRT) methods to quantify SUD severity taking into account all current and lifetime comorbid patterns in a mathematically accurate fashion, thereby enabling delineation of the covariation between severity of ND vulnerability and severity of SUD outcome. The proposed research aligns with the applicant's efforts in science advocacy pertaining to SUD etiology and prevention. By developing gender, ethnicity and age-appropriate algorithms for quantifying risk for SUD at the individual level withi a developmental framework, the NIH Roadmap framework will be advanced. Specifically, prevention can be designed that is empirically connected to the person's vulnerability and environment contexts. Hence, as a founding member of the Society of Prevention Research (SPR) and a member on the Board of the International Network of Patient-Centered Medicine (INPCM), a long-term career goal is to apply empirical research on SUD etiology for prevention practice.

描述（由申请人提供）：拟议的调查扩展了申请人的研究计划，旨在阐明物质使用障碍（SUD）的病因学。利用近 25 年已收集的纵向数据以及未来几年在 NIDA 资助的教育和药物滥用研究中心 (CEDAR) 中收集的数据，分析将针对加入个人脆弱性（特别是神经行为去抑制、ND ）和环境的多个方面来模拟 10-25 岁之间 SUD 的途径。 12 份已发表的报告显示了神经行为去抑制（包括心理失调的认知、情感和行为成分）： i) 具有出色的心理测量特性（包括预测有效性）； ii) 为发展框架中的 SUD 病因学建模提供信息； iii) 定义 10-12 岁儿童的极高风险子集，其发生 SUD 的概率为 0.95； iv) 与反映前额皮质功能障碍的电生理学和神经影像学变量相关； v) 调节家庭、同伴和邻居对 SUD 风险的不利影响。这个奖项将使我能够重新分配我的许多日常职责，同时保留作为中心 PI 的领导地位。该奖项将为我提供受保护的时间来进行研究，整合二十多年积累的数据以进行全面分析。这项研究以主题为指导，以实证为基础，并至少在五个方面具有创新性：i）它捕捉到了整合认知、情感和行为的 SUD 脆弱性； ii) 它综合考虑了各种适合年龄的环境影响； ii) 它提供了确定在 SUD 发展的主要年龄跨度中个人脆弱性和环境的各个组成部分是否存在差异显着性的机会； iv) 这是首次尝试确定描述每个年龄的特定“环境类型”的综合指数是否易患 SUD； v) 采用项目反应理论 (IRT) 方法来量化 SUD 严重性，以数学上准确的方式考虑所有当前和一生的共病模式，从而能够描述 ND 脆弱性的严重性和 SUD 结果的严重性之间的协变。拟议的研究与申请人在 SUD 病因学和预防相关的科学宣传方面的努力相一致。通过开发适合性别、种族和年龄的算法，在发展框架内量化个体层面的 SUD 风险，NIH 路线图框架将得到推进。具体来说，预防措施的设计可以根据经验与人的脆弱性和环境背景相关。因此，作为预防研究协会 (SPR) 的创始成员和国际以患者为中心的医学网络 (INPCM) 的董事会成员，长期的职业目标是将 SUD 病因学的实证研究应用于预防实践。