Informatics Center for Neurogenetics and Neurogenomics

神经遗传学和神经基因组学信息学中心

• 批准号: 7905138
• 负责人: NELSON B. FREIMER
• 金额: $ 76.95万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2014-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7905138
• 关键词: Informatics; Center; Neurogenetics; Neurogenomics

This is a proposal for an NINDS Institutional Center Core, the Informatics Center for Neurogenetics and Neurogenomics (ICNN) at UCLA. As with other areas of biomedical science, the post-genome era raises the prospect of transformational advances in neuroscience research. Neuroscience faces special challenges, however, in analysis, interpretation, and management of the vast quantities of information generated by genetic and genomic technologies. The phenotypic and organizational complexity of the nervous system calls for distinct analytical and informatics strategies and expertise. The ICNN will provide advanced analysis and informatics support to a highly interactive user group consisting of neuroscientists at UCLA, who are conducting basic, clinical, and translational research. These investigators have access to excellent facilities for genetics and genomics experimentation; the lack of corresponding resources in analysis and informatics constitutes a bottleneck in their research. ICNN faculty experts in statistical genetics, gene expression analysis, and bioinformatics will oversee the activities of highly-trained staff members who will accomplish three goals: 1) Providing expert consultation and analyses for neurogenetics and neurogenomics projects; 2) Developing and maintaining a shared computing resource that will include a computational cluster for computation-intensive analyses, web-servers and state of the art software tools for a wide range of applications (including user-friendly versions of public databases, as well as workstations on which ICNN users will be trained to employ these tools; 3) Providing hands-on training in analysis and informatics to the users.

这是对UCLA的NINDS机构中心核心，神经遗传学和神经基因组学信息中心（ICNN）的建议。与其他生物医学科学领域一样，基因组时代提高了神经科学研究中变革型进步的前景。然而，在分析，解释和管理遗传和基因组技术产生的大量信息时，神经科学面临着特殊的挑战。神经系统的表型和组织复杂性要求独特的分析和信息学策略和专业知识。 ICNN将为由UCLA的神经科学家组成的高度交互式用户组提供高级分析和信息学支持，UCLA正在进行基础，临床和转化研究。这些研究者可以使用遗传学和基因组学实验的出色设施。分析和信息学中缺乏相应的资源构成了他们的研究中的瓶颈。 ICNN统计遗传学，基因表达分析和生物信息学专家将监督训练有素的工作人员的活动，他们将实现三个目标：1）为神经源性和神经基因组学项目提供专家咨询和分析； 2）开发和维护共享的计算资源，其中包括用于计算密集型分析，网络服务器和ART软件工具的计算集群，用于广泛的应用程序（包括用户友好版的公共数据库版本，以及对ICNN用户进行培训的工作站的工作站，以培训这些工具；